Laminin-binding integrin gene copy number alterations in distinct epithelial-type cancers.
Author
Harryman, William LPond, Erika
Singh, Parminder
Little, Andrew S
Eschbacher, Jennifer M
Nagle, Raymond B
Cress, Anne E
Affiliation
Univ Arizona, Ctr CancIssue Date
2016
Metadata
Show full item recordPublisher
E-CENTURY PUBLISHING CORPCitation
Laminin-binding integrin gene copy number alterations in distinct epithelial-type cancers. 2016, 8 (2):940-54 Am J Transl ResRights
Copyright © e-Century Publishing Corporation, licensed under a Creative Commons Attribution Non-Commercial License.Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
The laminin-binding integrin (LBI) family are cell adhesion molecules that are essential for invasion and metastasis of human epithelial cancers and cell adhesion mediated drug resistance. We investigated whether copy number alteration (CNA) or mutations of a five-gene signature (ITGB4, ITGA3, LAMB3, PLEC, and SYNE3), representing essential genes for LBI adhesion, would correlate with patient outcomes within human epithelial-type tumor data sets currently available in an open access format.ISSN
1943-8141PubMed ID
27158381Version
Final published versionSponsors
The use of the Tissue Acquisition and Molecular Analysis Support Service (TACMASR) of the UA Cancer Center was essential for this work. Of particular note was the expert technical assistance of Ed Abril. The work was supported in part by CA P30 23074, CA164484 and CA159406.Additional Links
http://www.ajtr.org/files/ajtr0019463.pdfCollections
Except where otherwise noted, this item's license is described as Copyright © e-Century Publishing Corporation, licensed under a Creative Commons Attribution Non-Commercial License.
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