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dc.contributor.advisorRandolph, A.Den_US
dc.contributor.authorTavana-Roudsari, Aria.
dc.creatorTavana-Roudsari, Aria.en_US
dc.date.accessioned2011-10-31T17:30:33Z
dc.date.available2011-10-31T17:30:33Z
dc.date.issued1990en_US
dc.identifier.urihttp://hdl.handle.net/10150/185194
dc.description.abstractCrystallization from supercritical fluids was studied as a nontoxic, noncontaminating alternative to conventional techniques for purification and size manipulation of pharmaceutical solids. To proceed with crystallization solubilities of several pharmaceutical compounds in supercritical carbon dioxide were experimentally determined and modeled using solid-vapor phase equilibria. The compounds studied included benzoic acid, salicylic acid, aspirin, griseofulvin, and digoxin among others. A high pressure crystallizer was constructed and operated in batch and continuous modes. Supersaturation was generated by various schemes, such as optimal pressure reduction and salting-out. It was determined that, depending on the crystallization scheme, particles can be produced at submicron as well as large sizes. Particle nucleation and growth rates from saturated supercritical solutions were estimated and the product size distributions were simulated using the population balance theory. Observations were made regarding habit and morphology of particles nucleated and grown at supercritical conditions.
dc.language.isoenen_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.subjectChemistryen_US
dc.subjectEngineering.en_US
dc.titleCrystallization from supercritical fluids; application to pharmaceutical and biochemical compounds.en_US
dc.typetexten_US
dc.typeDissertation-Reproduction (electronic)en_US
dc.identifier.oclc709779936en_US
thesis.degree.grantorUniversity of Arizonaen_US
thesis.degree.leveldoctoralen_US
dc.contributor.committeememberShadman, F.en_US
dc.contributor.committeememberGuzman-Zamudio, R.en_US
dc.identifier.proquest9103054en_US
thesis.degree.disciplineChemical Engineeringen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.namePh.D.en_US
dc.description.noteThis item was digitized from a paper original and/or a microfilm copy. If you need higher-resolution images for any content in this item, please contact us at repository@u.library.arizona.edu.
dc.description.admin-noteOriginal file replaced with corrected file August 2023.
refterms.dateFOA2018-08-23T01:29:04Z
html.description.abstractCrystallization from supercritical fluids was studied as a nontoxic, noncontaminating alternative to conventional techniques for purification and size manipulation of pharmaceutical solids. To proceed with crystallization solubilities of several pharmaceutical compounds in supercritical carbon dioxide were experimentally determined and modeled using solid-vapor phase equilibria. The compounds studied included benzoic acid, salicylic acid, aspirin, griseofulvin, and digoxin among others. A high pressure crystallizer was constructed and operated in batch and continuous modes. Supersaturation was generated by various schemes, such as optimal pressure reduction and salting-out. It was determined that, depending on the crystallization scheme, particles can be produced at submicron as well as large sizes. Particle nucleation and growth rates from saturated supercritical solutions were estimated and the product size distributions were simulated using the population balance theory. Observations were made regarding habit and morphology of particles nucleated and grown at supercritical conditions.


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