Crystallization from supercritical fluids; application to pharmaceutical and biochemical compounds.
dc.contributor.advisor | Randolph, A.D | en_US |
dc.contributor.author | Tavana-Roudsari, Aria. | |
dc.creator | Tavana-Roudsari, Aria. | en_US |
dc.date.accessioned | 2011-10-31T17:30:33Z | |
dc.date.available | 2011-10-31T17:30:33Z | |
dc.date.issued | 1990 | en_US |
dc.identifier.uri | http://hdl.handle.net/10150/185194 | |
dc.description.abstract | Crystallization from supercritical fluids was studied as a nontoxic, noncontaminating alternative to conventional techniques for purification and size manipulation of pharmaceutical solids. To proceed with crystallization solubilities of several pharmaceutical compounds in supercritical carbon dioxide were experimentally determined and modeled using solid-vapor phase equilibria. The compounds studied included benzoic acid, salicylic acid, aspirin, griseofulvin, and digoxin among others. A high pressure crystallizer was constructed and operated in batch and continuous modes. Supersaturation was generated by various schemes, such as optimal pressure reduction and salting-out. It was determined that, depending on the crystallization scheme, particles can be produced at submicron as well as large sizes. Particle nucleation and growth rates from saturated supercritical solutions were estimated and the product size distributions were simulated using the population balance theory. Observations were made regarding habit and morphology of particles nucleated and grown at supercritical conditions. | |
dc.language.iso | en | en_US |
dc.publisher | The University of Arizona. | en_US |
dc.rights | Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author. | en_US |
dc.subject | Chemistry | en_US |
dc.subject | Engineering. | en_US |
dc.title | Crystallization from supercritical fluids; application to pharmaceutical and biochemical compounds. | en_US |
dc.type | text | en_US |
dc.type | Dissertation-Reproduction (electronic) | en_US |
dc.identifier.oclc | 709779936 | en_US |
thesis.degree.grantor | University of Arizona | en_US |
thesis.degree.level | doctoral | en_US |
dc.contributor.committeemember | Shadman, F. | en_US |
dc.contributor.committeemember | Guzman-Zamudio, R. | en_US |
dc.identifier.proquest | 9103054 | en_US |
thesis.degree.discipline | Chemical Engineering | en_US |
thesis.degree.discipline | Graduate College | en_US |
thesis.degree.name | Ph.D. | en_US |
dc.description.note | This item was digitized from a paper original and/or a microfilm copy. If you need higher-resolution images for any content in this item, please contact us at repository@u.library.arizona.edu. | |
dc.description.admin-note | Original file replaced with corrected file August 2023. | |
refterms.dateFOA | 2018-08-23T01:29:04Z | |
html.description.abstract | Crystallization from supercritical fluids was studied as a nontoxic, noncontaminating alternative to conventional techniques for purification and size manipulation of pharmaceutical solids. To proceed with crystallization solubilities of several pharmaceutical compounds in supercritical carbon dioxide were experimentally determined and modeled using solid-vapor phase equilibria. The compounds studied included benzoic acid, salicylic acid, aspirin, griseofulvin, and digoxin among others. A high pressure crystallizer was constructed and operated in batch and continuous modes. Supersaturation was generated by various schemes, such as optimal pressure reduction and salting-out. It was determined that, depending on the crystallization scheme, particles can be produced at submicron as well as large sizes. Particle nucleation and growth rates from saturated supercritical solutions were estimated and the product size distributions were simulated using the population balance theory. Observations were made regarding habit and morphology of particles nucleated and grown at supercritical conditions. |