Cellular information dynamics through transmembrane flow of ions

Persistent Link:
http://hdl.handle.net/10150/626193
Title:
Cellular information dynamics through transmembrane flow of ions
Author:
Gatenby, Robert A.; Frieden, B. Roy
Affiliation:
Univ Arizona, Coll Opt Sci
Issue Date:
2017-11-08
Publisher:
NATURE PUBLISHING GROUP
Citation:
Cellular information dynamics through transmembrane flow of ions 2017, 7 (1) Scientific Reports
Journal:
Scientific Reports
Rights:
© The Author(s) 2017. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License.
Collection Information:
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
Abstract:
We propose cells generate large transmembrane ion gradients to form information circuits that detect, process, and respond to environmental perturbations or signals. In this model, the specialized gates of transmembrane ion channels function as information detectors that communicate to the cell through rapid and (usually) local pulses of ions. Information in the ion "puffs" is received and processed by the cell through resulting changes in charge density and/or mobile cation (and/or anion) concentrations alter the localization and function of peripheral membrane proteins. The subsequent changes in protein binding to the membrane or activation of K+, Ca2+ or Mg2+ -dependent enzymes then constitute a cellular response to the perturbation. To test this hypothesis we analyzed ion-based signal transmission as a communication channel operating with coded inputs and decoded outputs. By minimizing the Kullback-Leibler cross entropy H-KL(p||q) between concentrations of the ion species inside p(i)(t) i = 1,.,N , and outside q(i)(t) the cell membrane, we find signal transmission through transmembrane ion flow forms an optimal Shannon information channel that minimizes information loss and maximizes transmission speed. We demonstrate the ion dynamics in neuronal action potentials described by Hodgkin and Huxley (including the equations themselves) represent a special case of these general information principles.
ISSN:
2045-2322
PubMed ID:
29118414
DOI:
10.1038/s41598-017-15182-2
Version:
Final published version
Sponsors:
National Cancer Institute Physical Science Oncology Center [U54 CA143970]; NCI CCSG Support Grant [P30 CA076292]
Additional Links:
http://www.nature.com/articles/s41598-017-15182-2

Full metadata record

DC FieldValue Language
dc.contributor.authorGatenby, Robert A.en
dc.contributor.authorFrieden, B. Royen
dc.date.accessioned2017-12-05T16:11:37Z-
dc.date.available2017-12-05T16:11:37Z-
dc.date.issued2017-11-08-
dc.identifier.citationCellular information dynamics through transmembrane flow of ions 2017, 7 (1) Scientific Reportsen
dc.identifier.issn2045-2322-
dc.identifier.pmid29118414-
dc.identifier.doi10.1038/s41598-017-15182-2-
dc.identifier.urihttp://hdl.handle.net/10150/626193-
dc.description.abstractWe propose cells generate large transmembrane ion gradients to form information circuits that detect, process, and respond to environmental perturbations or signals. In this model, the specialized gates of transmembrane ion channels function as information detectors that communicate to the cell through rapid and (usually) local pulses of ions. Information in the ion "puffs" is received and processed by the cell through resulting changes in charge density and/or mobile cation (and/or anion) concentrations alter the localization and function of peripheral membrane proteins. The subsequent changes in protein binding to the membrane or activation of K+, Ca2+ or Mg2+ -dependent enzymes then constitute a cellular response to the perturbation. To test this hypothesis we analyzed ion-based signal transmission as a communication channel operating with coded inputs and decoded outputs. By minimizing the Kullback-Leibler cross entropy H-KL(p||q) between concentrations of the ion species inside p(i)(t) i = 1,.,N , and outside q(i)(t) the cell membrane, we find signal transmission through transmembrane ion flow forms an optimal Shannon information channel that minimizes information loss and maximizes transmission speed. We demonstrate the ion dynamics in neuronal action potentials described by Hodgkin and Huxley (including the equations themselves) represent a special case of these general information principles.en
dc.description.sponsorshipNational Cancer Institute Physical Science Oncology Center [U54 CA143970]; NCI CCSG Support Grant [P30 CA076292]en
dc.language.isoenen
dc.publisherNATURE PUBLISHING GROUPen
dc.relation.urlhttp://www.nature.com/articles/s41598-017-15182-2en
dc.rights© The Author(s) 2017. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License.en
dc.titleCellular information dynamics through transmembrane flow of ionsen
dc.typeArticleen
dc.contributor.departmentUniv Arizona, Coll Opt Scien
dc.identifier.journalScientific Reportsen
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen

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