Relative efficacy of nicotinamide treatment of a mouse model of infantile Niemann-Pick C1 disease

Persistent Link:
http://hdl.handle.net/10150/622828
Title:
Relative efficacy of nicotinamide treatment of a mouse model of infantile Niemann-Pick C1 disease
Author:
Marshall, Craig A.; Borbon, Ivan A.; Erickson, Robert P.
Affiliation:
Department of Pediatrics, University of Arizona
Issue Date:
2016-10-25
Publisher:
SPRINGER HEIDELBERG
Citation:
Relative efficacy of nicotinamide treatment of a mouse model of infantile Niemann-Pick C1 disease 2016, 58 (1):99 Journal of Applied Genetics
Journal:
Journal of Applied Genetics
Rights:
© Institute of Plant Genetics, Polish Academy of Sciences, Poznan 2016
Collection Information:
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
Abstract:
Nicotinamide delivered in drinking water at about 2 g/kg/day significantly prolonged survival and showed a suggestive improvement on memory in the Npc1 (nih) / Npc1 (nih) mouse model of infantile NPC1 disease. It is likely that this role is due to its function as a histone deacetylase (HDAC) inhibitor although another HDAC inhibitor, valproic acid, was without effect. Nicotinamide could also work by preventing/reversing oxidative stress.
Note:
12 month embargo; First Online: 25 October 2016
ISSN:
1234-1983; 2190-3883
PubMed ID:
27783333
DOI:
10.1007/s13353-016-0367-0
Keywords:
Histone deacetylase; Nicotinamide; Niemann-Pick C1 disease; Oxidative stress; Sirtuin; Valproic acid
Version:
Final accepted manuscript
Sponsors:
Wings Like Eagles Foundation, Tucson, AZ
Additional Links:
http://link.springer.com/10.1007/s13353-016-0367-0

Full metadata record

DC FieldValue Language
dc.contributor.authorMarshall, Craig A.en
dc.contributor.authorBorbon, Ivan A.en
dc.contributor.authorErickson, Robert P.en
dc.date.accessioned2017-03-14T22:58:39Z-
dc.date.available2017-03-14T22:58:39Z-
dc.date.issued2016-10-25-
dc.identifier.citationRelative efficacy of nicotinamide treatment of a mouse model of infantile Niemann-Pick C1 disease 2016, 58 (1):99 Journal of Applied Geneticsen
dc.identifier.issn1234-1983-
dc.identifier.issn2190-3883-
dc.identifier.pmid27783333-
dc.identifier.doi10.1007/s13353-016-0367-0-
dc.identifier.urihttp://hdl.handle.net/10150/622828-
dc.description.abstractNicotinamide delivered in drinking water at about 2 g/kg/day significantly prolonged survival and showed a suggestive improvement on memory in the Npc1 (nih) / Npc1 (nih) mouse model of infantile NPC1 disease. It is likely that this role is due to its function as a histone deacetylase (HDAC) inhibitor although another HDAC inhibitor, valproic acid, was without effect. Nicotinamide could also work by preventing/reversing oxidative stress.en
dc.description.sponsorshipWings Like Eagles Foundation, Tucson, AZen
dc.language.isoenen
dc.publisherSPRINGER HEIDELBERGen
dc.relation.urlhttp://link.springer.com/10.1007/s13353-016-0367-0en
dc.rights© Institute of Plant Genetics, Polish Academy of Sciences, Poznan 2016en
dc.subjectHistone deacetylaseen
dc.subjectNicotinamideen
dc.subjectNiemann-Pick C1 diseaseen
dc.subjectOxidative stressen
dc.subjectSirtuinen
dc.subjectValproic aciden
dc.titleRelative efficacy of nicotinamide treatment of a mouse model of infantile Niemann-Pick C1 diseaseen
dc.typeArticleen
dc.contributor.departmentDepartment of Pediatrics, University of Arizonaen
dc.identifier.journalJournal of Applied Geneticsen
dc.description.note12 month embargo; First Online: 25 October 2016en
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en
dc.eprint.versionFinal accepted manuscripten

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