Structuring evolution: biochemical networks and metabolic diversification in birds

Persistent Link:
http://hdl.handle.net/10150/620926
Title:
Structuring evolution: biochemical networks and metabolic diversification in birds
Author:
Morrison, Erin S.; Badyaev, Alexander V.
Affiliation:
Department of Ecology and Evolutionary Biology, University of Arizona
Issue Date:
2016-08-25
Publisher:
BioMed Central
Citation:
Morrison, E.S and Badyaev, A.V. 2016. Structuring evolution: biochemical networks and metabolic diversification in birds. BMC Evolutionary Biology 16: 168.
Journal:
BMC Evolutionary Biology
Rights:
© 2016 The Author(s). Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), As authors of articles published in BMC Evolutionary Biology you are the copyright holders of your article and have granted to any third party, in advance and in perpetuity, the right to use, reproduce or disseminate your article, according to the BioMed Central license agreement.
Collection Information:
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
Abstract:
Background Recurrence and predictability of evolution are thought to reflect the correspondence between genomic and phenotypic dimensions of organisms, and the connectivity in deterministic networks within these dimensions. Direct examination of the correspondence between opportunities for diversification imbedded in such networks and realized diversity is illuminating, but is empirically challenging because both the deterministic networks and phenotypic diversity are modified in the course of evolution. Here we overcome this problem by directly comparing the structure of a “global” carotenoid network – comprising of all known enzymatic reactions among naturally occurring carotenoids – with the patterns of evolutionary diversification in carotenoid-producing metabolic networks utilized by birds. Results We found that phenotypic diversification in carotenoid networks across 250 species was closely associated with enzymatic connectivity of the underlying biochemical network – compounds with greater connectivity occurred the most frequently across species and were the hotspots of metabolic pathway diversification. In contrast, we found no evidence for diversification along the metabolic pathways, corroborating findings that the utilization of the global carotenoid network was not strongly influenced by history in avian evolution. Conclusions The finding that the diversification in species-specific carotenoid networks is qualitatively predictable from the connectivity of the underlying enzymatic network points to significant structural determinism in phenotypic evolution.
Note:
Open access.
DOI:
10.1186/s12862-016-0731-z
Keywords:
Network Structure; metabolic pathways; phenotypic diversity
Version:
Final published version
Sponsors:
David and Lucille Packard Foundation, Amherst College graduate fellowships
Additional Links:
http://www.biomedcentral.com/1471-2148/16/168

Full metadata record

DC FieldValue Language
dc.contributor.authorMorrison, Erin S.en
dc.contributor.authorBadyaev, Alexander V.en
dc.date.accessioned2016-10-11T22:55:55Z-
dc.date.available2016-10-11T22:55:55Z-
dc.date.issued2016-08-25-
dc.identifier.citationMorrison, E.S and Badyaev, A.V. 2016. Structuring evolution: biochemical networks and metabolic diversification in birds. BMC Evolutionary Biology 16: 168.en
dc.identifier.doi10.1186/s12862-016-0731-z-
dc.identifier.urihttp://hdl.handle.net/10150/620926-
dc.description.abstractBackground Recurrence and predictability of evolution are thought to reflect the correspondence between genomic and phenotypic dimensions of organisms, and the connectivity in deterministic networks within these dimensions. Direct examination of the correspondence between opportunities for diversification imbedded in such networks and realized diversity is illuminating, but is empirically challenging because both the deterministic networks and phenotypic diversity are modified in the course of evolution. Here we overcome this problem by directly comparing the structure of a “global” carotenoid network – comprising of all known enzymatic reactions among naturally occurring carotenoids – with the patterns of evolutionary diversification in carotenoid-producing metabolic networks utilized by birds. Results We found that phenotypic diversification in carotenoid networks across 250 species was closely associated with enzymatic connectivity of the underlying biochemical network – compounds with greater connectivity occurred the most frequently across species and were the hotspots of metabolic pathway diversification. In contrast, we found no evidence for diversification along the metabolic pathways, corroborating findings that the utilization of the global carotenoid network was not strongly influenced by history in avian evolution. Conclusions The finding that the diversification in species-specific carotenoid networks is qualitatively predictable from the connectivity of the underlying enzymatic network points to significant structural determinism in phenotypic evolution.en
dc.description.sponsorshipDavid and Lucille Packard Foundation, Amherst College graduate fellowshipsen
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urlhttp://www.biomedcentral.com/1471-2148/16/168en
dc.rights© 2016 The Author(s). Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), As authors of articles published in BMC Evolutionary Biology you are the copyright holders of your article and have granted to any third party, in advance and in perpetuity, the right to use, reproduce or disseminate your article, according to the BioMed Central license agreement.en
dc.subjectNetwork Structureen
dc.subjectmetabolic pathwaysen
dc.subjectphenotypic diversityen
dc.titleStructuring evolution: biochemical networks and metabolic diversification in birdsen
dc.typeArticleen
dc.contributor.departmentDepartment of Ecology and Evolutionary Biology, University of Arizonaen
dc.identifier.journalBMC Evolutionary Biologyen
dc.description.noteOpen access.en
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen
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