A Rare Presentation of In Situ Mantle Cell Lymphoma and Follicular Lymphoma: A Case Report and Review of the Literature

Persistent Link:
http://hdl.handle.net/10150/618976
Title:
A Rare Presentation of In Situ Mantle Cell Lymphoma and Follicular Lymphoma: A Case Report and Review of the Literature
Author:
Taverna, Josephine ( 0000-0002-9191-9412 ) ; Nair, Anju; Yun, Seongseok; Paulson, Spencer; Schatz, Jonathan H.; Persky, Daniel; Fuchs, Deborah; Puvvada, Soham
Affiliation:
Univ Arizona, Arizona Canc Ctr
Issue Date:
2016-08-27
Publisher:
Hindawi
Citation:
Josephine Taverna, Anju Nair, Seongseok Yun, et al., “A Rare Presentation of In Situ Mantle Cell Lymphoma and Follicular Lymphoma: A Case Report and Review of the Literature,” Case Reports in Hematology, vol. 2014, Article ID 145129, 7 pages, 2014. doi:10.1155/2014/145129
Journal:
Case Studies In Hematology
Rights:
Copyright © 2014 Josephine Taverna et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Collection Information:
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
Abstract:
A 65-year-old gentleman presented with left groin swelling over the course of two months. Physical exam revealed nontender left inguinal adenopathy, and computed tomography scans detected multiple lymph nodes in the mesenteric, aortocaval, and right common iliac regions. An excisional lymph node biopsy was performed. Pathologic evaluation demonstrated follicular center site which stained positive for PAX5, CD20, CD10, Bcl-2, Bcl-6, and mantle zone cells. These findings demonstrated CCND1 and CD5 positivity, suggesting composite lymphoma comprising follicular lymphoma (FL) with in situ mantle cell lymphoma (MCLIS). FL is known as indolent non-Hodgkin lymphoma; however, the clinical significance of a coexisting MCLIS continues to be elusive, and optimal management of these patients remains largely unknown. This case illustrates the diagnostic and therapeutic challenges of composite lymphomas. This paper also discusses advances in molecular pathogenesis and lymphoma genomics which offer novel insights into these rare diseases.
Note:
Paid by UA Open Access Fund
DOI:
http://dx.doi.org/10.1155/2014/145129
Version:
Final published version
Additional Links:
http://www.hindawi.com/journals/crihem/2014/145129/abs/

Full metadata record

DC FieldValue Language
dc.contributor.authorTaverna, Josephineen
dc.contributor.authorNair, Anjuen
dc.contributor.authorYun, Seongseoken
dc.contributor.authorPaulson, Spenceren
dc.contributor.authorSchatz, Jonathan H.en
dc.contributor.authorPersky, Danielen
dc.contributor.authorFuchs, Deborahen
dc.contributor.authorPuvvada, Sohamen
dc.date.accessioned2016-08-27T00:48:59Z-
dc.date.available2016-08-27T00:48:59Z-
dc.date.issued2016-08-27-
dc.identifier.citationJosephine Taverna, Anju Nair, Seongseok Yun, et al., “A Rare Presentation of In Situ Mantle Cell Lymphoma and Follicular Lymphoma: A Case Report and Review of the Literature,” Case Reports in Hematology, vol. 2014, Article ID 145129, 7 pages, 2014. doi:10.1155/2014/145129en
dc.identifier.doihttp://dx.doi.org/10.1155/2014/145129-
dc.identifier.urihttp://hdl.handle.net/10150/618976-
dc.description.abstractA 65-year-old gentleman presented with left groin swelling over the course of two months. Physical exam revealed nontender left inguinal adenopathy, and computed tomography scans detected multiple lymph nodes in the mesenteric, aortocaval, and right common iliac regions. An excisional lymph node biopsy was performed. Pathologic evaluation demonstrated follicular center site which stained positive for PAX5, CD20, CD10, Bcl-2, Bcl-6, and mantle zone cells. These findings demonstrated CCND1 and CD5 positivity, suggesting composite lymphoma comprising follicular lymphoma (FL) with in situ mantle cell lymphoma (MCLIS). FL is known as indolent non-Hodgkin lymphoma; however, the clinical significance of a coexisting MCLIS continues to be elusive, and optimal management of these patients remains largely unknown. This case illustrates the diagnostic and therapeutic challenges of composite lymphomas. This paper also discusses advances in molecular pathogenesis and lymphoma genomics which offer novel insights into these rare diseases.en
dc.language.isoenen
dc.publisherHindawien
dc.relation.urlhttp://www.hindawi.com/journals/crihem/2014/145129/abs/en
dc.rightsCopyright © 2014 Josephine Taverna et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.titleA Rare Presentation of In Situ Mantle Cell Lymphoma and Follicular Lymphoma: A Case Report and Review of the Literatureen
dc.typeArticleen
dc.contributor.departmentUniv Arizona, Arizona Canc Ctren
dc.identifier.journalCase Studies In Hematologyen
dc.description.notePaid by UA Open Access Funden
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen
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