Association of Children’s Urinary CC16 Levels with Arsenic Concentrations in Multiple Environmental Media

Persistent Link:
http://hdl.handle.net/10150/617372
Title:
Association of Children’s Urinary CC16 Levels with Arsenic Concentrations in Multiple Environmental Media
Author:
Beamer, Paloma; Klimecki, Walter; Loh, Miranda; Van Horne, Yoshira; Sugeng, Anastasia; Lothrop, Nathan; Billheimer, Dean; Guerra, Stefano; Lantz, Robert; Canales, Robert; Martinez, Fernando
Affiliation:
Univ Arizona, Asthma & Airways Dis Res Ctr; Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth; Univ Arizona, Dept Chem & Environm Engn; Univ Arizona, Dept Pharmacol & Toxicol, Coll Pharm
Issue Date:
2016-05-23
Publisher:
MDPI AG
Citation:
Association of Children’s Urinary CC16 Levels with Arsenic Concentrations in Multiple Environmental Media 2016, 13 (5):521 International Journal of Environmental Research and Public Health
Journal:
International Journal of Environmental Research and Public Health
Rights:
© 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
Collection Information:
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
Abstract:
Arsenic exposure has been associated with decreased club cell secretory protein (CC16) levels in adults. Further, both arsenic exposure and decreased levels of CC16 in childhood have been associated with decreased adult lung function. Our objective was to determine if urinary CC16 levels in children are associated with arsenic concentrations in environmental media collected from their homes. Yard soil, house dust, and tap water were taken from 34 homes. Urine and toenail samples were collected from 68 children. All concentrations were natural log-transformed prior to data analysis. There were associations between urinary CC16 and arsenic concentration in soil (b = -0.43, p = 0.001, R-2 = 0.08), water (b = -0.22, p = 0.07, R-2 = 0.03), house dust (b = -0.37, p = 0.07, R-2 = 0.04), and dust loading (b = -0.21, p = 0.04, R-2 = 0.04). In multiple analyses, only the concentration of arsenic in soil was associated with urinary CC16 levels (b = -0.42, p = 0.02, R-2 = 0.14 (full model)) after accounting for other factors. The association between urinary CC16 and soil arsenic may suggest that localized arsenic exposure in the lungs could damage the airway epithelium and predispose children for diminished lung function. Future work to assess this possible mechanism should examine potential associations between airborne arsenic exposures, CC16 levels, lung function, and other possible confounders in children in arsenic-impacted communities.
Note:
Open access.
ISSN:
1660-4601
DOI:
10.3390/ijerph13050521
Keywords:
children; arsenic; respiratory health; CC16; uteroglobulin; multi-route exposure assessment; soil; drinking water
Version:
Final published version
Additional Links:
http://www.mdpi.com/1660-4601/13/5/521

Full metadata record

DC FieldValue Language
dc.contributor.authorBeamer, Palomaen
dc.contributor.authorKlimecki, Walteren
dc.contributor.authorLoh, Mirandaen
dc.contributor.authorVan Horne, Yoshiraen
dc.contributor.authorSugeng, Anastasiaen
dc.contributor.authorLothrop, Nathanen
dc.contributor.authorBillheimer, Deanen
dc.contributor.authorGuerra, Stefanoen
dc.contributor.authorLantz, Roberten
dc.contributor.authorCanales, Roberten
dc.contributor.authorMartinez, Fernandoen
dc.date.accessioned2016-07-23T00:14:09Z-
dc.date.available2016-07-23T00:14:09Z-
dc.date.issued2016-05-23-
dc.identifier.citationAssociation of Children’s Urinary CC16 Levels with Arsenic Concentrations in Multiple Environmental Media 2016, 13 (5):521 International Journal of Environmental Research and Public Healthen
dc.identifier.issn1660-4601-
dc.identifier.doi10.3390/ijerph13050521-
dc.identifier.urihttp://hdl.handle.net/10150/617372-
dc.description.abstractArsenic exposure has been associated with decreased club cell secretory protein (CC16) levels in adults. Further, both arsenic exposure and decreased levels of CC16 in childhood have been associated with decreased adult lung function. Our objective was to determine if urinary CC16 levels in children are associated with arsenic concentrations in environmental media collected from their homes. Yard soil, house dust, and tap water were taken from 34 homes. Urine and toenail samples were collected from 68 children. All concentrations were natural log-transformed prior to data analysis. There were associations between urinary CC16 and arsenic concentration in soil (b = -0.43, p = 0.001, R-2 = 0.08), water (b = -0.22, p = 0.07, R-2 = 0.03), house dust (b = -0.37, p = 0.07, R-2 = 0.04), and dust loading (b = -0.21, p = 0.04, R-2 = 0.04). In multiple analyses, only the concentration of arsenic in soil was associated with urinary CC16 levels (b = -0.42, p = 0.02, R-2 = 0.14 (full model)) after accounting for other factors. The association between urinary CC16 and soil arsenic may suggest that localized arsenic exposure in the lungs could damage the airway epithelium and predispose children for diminished lung function. Future work to assess this possible mechanism should examine potential associations between airborne arsenic exposures, CC16 levels, lung function, and other possible confounders in children in arsenic-impacted communities.en
dc.language.isoenen
dc.publisherMDPI AGen
dc.relation.urlhttp://www.mdpi.com/1660-4601/13/5/521en
dc.rights© 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).en
dc.subjectchildrenen
dc.subjectarsenicen
dc.subjectrespiratory healthen
dc.subjectCC16en
dc.subjectuteroglobulinen
dc.subjectmulti-route exposure assessmenten
dc.subjectsoilen
dc.subjectdrinking wateren
dc.titleAssociation of Children’s Urinary CC16 Levels with Arsenic Concentrations in Multiple Environmental Mediaen
dc.typeArticleen
dc.contributor.departmentUniv Arizona, Asthma & Airways Dis Res Ctren
dc.contributor.departmentUniv Arizona, Mel & Enid Zuckerman Coll Publ Hlthen
dc.contributor.departmentUniv Arizona, Dept Chem & Environm Engnen
dc.contributor.departmentUniv Arizona, Dept Pharmacol & Toxicol, Coll Pharmen
dc.identifier.journalInternational Journal of Environmental Research and Public Healthen
dc.description.noteOpen access.en
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen
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