Light adaptation alters inner retinal inhibition to shape OFF retinal pathway signaling.

Persistent Link:
http://hdl.handle.net/10150/617205
Title:
Light adaptation alters inner retinal inhibition to shape OFF retinal pathway signaling.
Author:
Mazade, Reece E; Eggers, Erika D
Affiliation:
University of Arizona, Departments of Physiology and Biomedical Engineering
Issue Date:
2016-06-01
Publisher:
AMER PHYSIOLOGICAL SOC
Citation:
Light adaptation alters inner retinal inhibition to shape OFF retinal pathway signaling. 2016, 115 (6):2761-78 J. Neurophysiol.
Journal:
Journal of neurophysiology
Rights:
Copyright © 2016 by the American Physiological Society.
Collection Information:
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
Abstract:
The retina adjusts its signaling gain over a wide range of light levels. A functional result of this is increased visual acuity at brighter luminance levels (light adaptation) due to shifts in the excitatory center-inhibitory surround receptive field parameters of ganglion cells that increases their sensitivity to smaller light stimuli. Recent work supports the idea that changes in ganglion cell spatial sensitivity with background luminance are due in part to inner retinal mechanisms, possibly including modulation of inhibition onto bipolar cells. To determine how the receptive fields of OFF cone bipolar cells may contribute to changes in ganglion cell resolution, the spatial extent and magnitude of inhibitory and excitatory inputs were measured from OFF bipolar cells under dark- and light-adapted conditions. There was no change in the OFF bipolar cell excitatory input with light adaptation; however, the spatial distributions of inhibitory inputs, including both glycinergic and GABAergic sources, became significantly narrower, smaller, and more transient. The magnitude and size of the OFF bipolar cell center-surround receptive fields as well as light-adapted changes in resting membrane potential were incorporated into a spatial model of OFF bipolar cell output to the downstream ganglion cells, which predicted an increase in signal output strength with light adaptation. We show a prominent role for inner retinal spatial signals in modulating the modeled strength of bipolar cell output to potentially play a role in ganglion cell visual sensitivity and acuity.
Note:
Published 24 February 2016; final publication 1 June 2016. 12 month embargo.
ISSN:
1522-1598
PubMed ID:
26912599
DOI:
10.1152/jn.00948.2015
Version:
Final accepted manuscript
Additional Links:
https://jn.physiology.org/content/115/6/2761

Full metadata record

DC FieldValue Language
dc.contributor.authorMazade, Reece Een
dc.contributor.authorEggers, Erika Den
dc.date.accessioned2016-07-19T02:01:51Z-
dc.date.available2016-07-19T02:01:51Z-
dc.date.issued2016-06-01-
dc.identifier.citationLight adaptation alters inner retinal inhibition to shape OFF retinal pathway signaling. 2016, 115 (6):2761-78 J. Neurophysiol.en
dc.identifier.issn1522-1598-
dc.identifier.pmid26912599-
dc.identifier.doi10.1152/jn.00948.2015-
dc.identifier.urihttp://hdl.handle.net/10150/617205-
dc.description.abstractThe retina adjusts its signaling gain over a wide range of light levels. A functional result of this is increased visual acuity at brighter luminance levels (light adaptation) due to shifts in the excitatory center-inhibitory surround receptive field parameters of ganglion cells that increases their sensitivity to smaller light stimuli. Recent work supports the idea that changes in ganglion cell spatial sensitivity with background luminance are due in part to inner retinal mechanisms, possibly including modulation of inhibition onto bipolar cells. To determine how the receptive fields of OFF cone bipolar cells may contribute to changes in ganglion cell resolution, the spatial extent and magnitude of inhibitory and excitatory inputs were measured from OFF bipolar cells under dark- and light-adapted conditions. There was no change in the OFF bipolar cell excitatory input with light adaptation; however, the spatial distributions of inhibitory inputs, including both glycinergic and GABAergic sources, became significantly narrower, smaller, and more transient. The magnitude and size of the OFF bipolar cell center-surround receptive fields as well as light-adapted changes in resting membrane potential were incorporated into a spatial model of OFF bipolar cell output to the downstream ganglion cells, which predicted an increase in signal output strength with light adaptation. We show a prominent role for inner retinal spatial signals in modulating the modeled strength of bipolar cell output to potentially play a role in ganglion cell visual sensitivity and acuity.en
dc.language.isoenen
dc.publisherAMER PHYSIOLOGICAL SOCen
dc.relation.urlhttps://jn.physiology.org/content/115/6/2761en
dc.rightsCopyright © 2016 by the American Physiological Society.en
dc.titleLight adaptation alters inner retinal inhibition to shape OFF retinal pathway signaling.en
dc.typeArticleen
dc.contributor.departmentUniversity of Arizona, Departments of Physiology and Biomedical Engineeringen
dc.identifier.journalJournal of neurophysiologyen
dc.description.notePublished 24 February 2016; final publication 1 June 2016. 12 month embargo.en
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en
dc.eprint.versionFinal accepted manuscripten
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