Neighborhood socioeconomic position and tuberculosis transmission: a retrospective cohort study

Persistent Link:
http://hdl.handle.net/10150/617199
Title:
Neighborhood socioeconomic position and tuberculosis transmission: a retrospective cohort study
Author:
Oren, Eyal; Narita, Masahiro; Nolan, Charles; Mayer, Jonathan
Affiliation:
Division of Epidemiology & Biostatistics, University of Arizona
Issue Date:
2014-04-27
Publisher:
BMC
Citation:
Neighborhood socioeconomic position and tuberculosis transmission: a retrospective cohort study 2014, 14 (1) BMC Infectious Diseases
Journal:
BMC Infectious Diseases
Rights:
© 2014 Oren et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0).
Collection Information:
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
Abstract:
Background: Current understanding of tuberculosis (TB) genotype clustering in the US is based on individual risk factors. This study sought to identify whether area-based socioeconomic status (SES) was associated with genotypic clustering among culture-confirmed TB cases. Methods: A retrospective cohort analysis was performed on data collected on persons with incident TB in King County, Washington, 2004–2008. Multilevel models were used to identify the relationship between area-level SES at the block group level and clustering utilizing a socioeconomic position index (SEP). Results: Of 519 patients with a known genotyping result and block group, 212 (41%) of isolates clustered genotypically. Analyses suggested an association between lower area-based SES and increased recent TB transmission, particularly among US-born populations. Models in which community characteristics were measured at the block group level demonstrated that lower area-based SEP was positively associated with genotypic clustering after controlling for individual covariates. However, the trend in higher clustering odds with lower SEP index quartile diminished when additional block-group covariates. Conclusions: Results stress the need for TB control interventions that take area-based measures into account, with particular focus on poor neighborhoods. Interventions based on area-based characteristics, such as improving case finding strategies, utilizing location-based screening and addressing social inequalities, could reduce recent rates of transmission.
Description:
UA Open Access Publishing Fund
ISSN:
1471-2334
DOI:
10.1186/1471-2334-14-227
Keywords:
Tuberculosis; Genotyping; Socioeconomic status; Infectious disease transmission; Multilevel; Molecular epidemiology
Version:
Final published version
Additional Links:
http://bmcinfectdis.biomedcentral.com/articles/10.1186/1471-2334-14-227

Full metadata record

DC FieldValue Language
dc.contributor.authorOren, Eyalen
dc.contributor.authorNarita, Masahiroen
dc.contributor.authorNolan, Charlesen
dc.contributor.authorMayer, Jonathanen
dc.date.accessioned2016-07-19T01:20:43Z-
dc.date.available2016-07-19T01:20:43Z-
dc.date.issued2014-04-27-
dc.identifier.citationNeighborhood socioeconomic position and tuberculosis transmission: a retrospective cohort study 2014, 14 (1) BMC Infectious Diseasesen
dc.identifier.issn1471-2334-
dc.identifier.doi10.1186/1471-2334-14-227-
dc.identifier.urihttp://hdl.handle.net/10150/617199-
dc.descriptionUA Open Access Publishing Funden
dc.description.abstractBackground: Current understanding of tuberculosis (TB) genotype clustering in the US is based on individual risk factors. This study sought to identify whether area-based socioeconomic status (SES) was associated with genotypic clustering among culture-confirmed TB cases. Methods: A retrospective cohort analysis was performed on data collected on persons with incident TB in King County, Washington, 2004–2008. Multilevel models were used to identify the relationship between area-level SES at the block group level and clustering utilizing a socioeconomic position index (SEP). Results: Of 519 patients with a known genotyping result and block group, 212 (41%) of isolates clustered genotypically. Analyses suggested an association between lower area-based SES and increased recent TB transmission, particularly among US-born populations. Models in which community characteristics were measured at the block group level demonstrated that lower area-based SEP was positively associated with genotypic clustering after controlling for individual covariates. However, the trend in higher clustering odds with lower SEP index quartile diminished when additional block-group covariates. Conclusions: Results stress the need for TB control interventions that take area-based measures into account, with particular focus on poor neighborhoods. Interventions based on area-based characteristics, such as improving case finding strategies, utilizing location-based screening and addressing social inequalities, could reduce recent rates of transmission.en
dc.language.isoenen
dc.publisherBMCen
dc.relation.urlhttp://bmcinfectdis.biomedcentral.com/articles/10.1186/1471-2334-14-227en
dc.rights© 2014 Oren et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0).en
dc.subjectTuberculosisen
dc.subjectGenotypingen
dc.subjectSocioeconomic statusen
dc.subjectInfectious disease transmissionen
dc.subjectMultilevelen
dc.subjectMolecular epidemiologyen
dc.titleNeighborhood socioeconomic position and tuberculosis transmission: a retrospective cohort studyen
dc.typeArticleen
dc.contributor.departmentDivision of Epidemiology & Biostatistics, University of Arizonaen
dc.identifier.journalBMC Infectious Diseasesen
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen
All Items in UA Campus Repository are protected by copyright, with all rights reserved, unless otherwise indicated.