Laminin-binding integrin gene copy number alterations in distinct epithelial-type cancers.

Persistent Link:
http://hdl.handle.net/10150/615112
Title:
Laminin-binding integrin gene copy number alterations in distinct epithelial-type cancers.
Author:
Harryman, William L; Pond, Erika; Singh, Parminder; Little, Andrew S; Eschbacher, Jennifer M; Nagle, Raymond B; Cress, Anne E
Affiliation:
Univ Arizona, Ctr Canc
Issue Date:
2016
Publisher:
E-CENTURY PUBLISHING CORP
Citation:
Laminin-binding integrin gene copy number alterations in distinct epithelial-type cancers. 2016, 8 (2):940-54 Am J Transl Res
Journal:
American journal of translational research
Rights:
Creative Commons Attribution Non-Commercial License
Collection Information:
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
Abstract:
The laminin-binding integrin (LBI) family are cell adhesion molecules that are essential for invasion and metastasis of human epithelial cancers and cell adhesion mediated drug resistance. We investigated whether copy number alteration (CNA) or mutations of a five-gene signature (ITGB4, ITGA3, LAMB3, PLEC, and SYNE3), representing essential genes for LBI adhesion, would correlate with patient outcomes within human epithelial-type tumor data sets currently available in an open access format.
ISSN:
1943-8141
PubMed ID:
27158381
Keywords:
Cancer; gene copy; laminin; integrin; cBioPortal; copy number alterations
Version:
Final published version
Sponsors:
The use of the Tissue Acquisition and Molecular Analysis Support Service (TACMASR) of the UA Cancer Center was essential for this work. Of particular note was the expert technical assistance of Ed Abril. The work was supported in part by CA P30 23074, CA164484 and CA159406.
Additional Links:
http://www.ajtr.org/files/ajtr0019463.pdf

Full metadata record

DC FieldValue Language
dc.contributor.authorHarryman, William Len
dc.contributor.authorPond, Erikaen
dc.contributor.authorSingh, Parminderen
dc.contributor.authorLittle, Andrew Sen
dc.contributor.authorEschbacher, Jennifer Men
dc.contributor.authorNagle, Raymond Ben
dc.contributor.authorCress, Anne Een
dc.date.accessioned2016-06-30T02:29:46Z-
dc.date.available2016-06-30T02:29:46Z-
dc.date.issued2016-
dc.identifier.citationLaminin-binding integrin gene copy number alterations in distinct epithelial-type cancers. 2016, 8 (2):940-54 Am J Transl Resen
dc.identifier.issn1943-8141-
dc.identifier.pmid27158381-
dc.identifier.urihttp://hdl.handle.net/10150/615112-
dc.description.abstractThe laminin-binding integrin (LBI) family are cell adhesion molecules that are essential for invasion and metastasis of human epithelial cancers and cell adhesion mediated drug resistance. We investigated whether copy number alteration (CNA) or mutations of a five-gene signature (ITGB4, ITGA3, LAMB3, PLEC, and SYNE3), representing essential genes for LBI adhesion, would correlate with patient outcomes within human epithelial-type tumor data sets currently available in an open access format.en
dc.description.sponsorshipThe use of the Tissue Acquisition and Molecular Analysis Support Service (TACMASR) of the UA Cancer Center was essential for this work. Of particular note was the expert technical assistance of Ed Abril. The work was supported in part by CA P30 23074, CA164484 and CA159406.en
dc.language.isoenen
dc.publisherE-CENTURY PUBLISHING CORPen
dc.relation.urlhttp://www.ajtr.org/files/ajtr0019463.pdfen
dc.rightsCreative Commons Attribution Non-Commercial Licenseen
dc.subjectCanceren
dc.subjectgene copyen
dc.subjectlamininen
dc.subjectintegrinen
dc.subjectcBioPortalen
dc.subjectcopy number alterationsen
dc.titleLaminin-binding integrin gene copy number alterations in distinct epithelial-type cancers.en
dc.typeArticleen
dc.contributor.departmentUniv Arizona, Ctr Cancen
dc.identifier.journalAmerican journal of translational researchen
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen

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