Prenatal exposure to cannabis and maternal and child health outcomes: a systematic review and meta-analysis

Persistent Link:
http://hdl.handle.net/10150/614985
Title:
Prenatal exposure to cannabis and maternal and child health outcomes: a systematic review and meta-analysis
Author:
Gunn, J K L; Rosales, C B; Center, K E; Nuñez, A; Gibson, S J; Christ, C; Ehiri, J E
Affiliation:
Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Dept Epidemiol & Biostat; Univ Arizona, Dept Obstet & Gynecol; Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Arizona Hlth Sci Lib; Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Dept Hlth Promot Sci
Issue Date:
2016-04-05
Publisher:
BMJ PUBLISHING GROUP
Citation:
Prenatal exposure to cannabis and maternal and child health outcomes: a systematic review and meta-analysis 2016, 6 (4):e009986 BMJ Open
Journal:
BMJ Open
Rights:
This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
Collection Information:
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
Abstract:
Objective: To assess the effects of use of cannabis during pregnancy on maternal and fetal outcomes. Data sources: 7 electronic databases were searched from inception to 1 April 2014. Studies that investigated the effects of use of cannabis during pregnancy on maternal and fetal outcomes were included. Study selection: Case-control studies, cross-sectional and cohort studies were included. Data extraction and synthesis: Data synthesis was undertaken via systematic review and meta-analysis of available evidence. All review stages were conducted independently by 2 reviewers. Main outcomes and measures: Maternal, fetal and neonatal outcomes up to 6 weeks postpartum after exposure to cannabis. Meta-analyses were conducted on variables that had 3 or more studies that measured an outcome in a consistent manner. Outcomes for which meta-analyses were conducted included: anaemia, birth weight, low birth weight, neonatal length, placement in the neonatal intensive care unit, gestational age, head circumference and preterm birth. Results: 24 studies were included in the review. Results of the meta-analysis demonstrated that women who used cannabis during pregnancy had an increase in the odds of anaemia (pooled OR (pOR)=1.36: 95% CI 1.10 to 1.69) compared with women who did not use cannabis during pregnancy. Infants exposed to cannabis in utero had a decrease in birth weight (low birth weight pOR=1.77: 95% CI 1.04 to 3.01; pooled mean difference (pMD) for birth weight=109.42 g: 38.72 to 180.12) compared with infants whose mothers did not use cannabis during pregnancy. Infants exposed to cannabis in utero were also more likely to need placement in the neonatal intensive care unit compared with infants whose mothers did not use cannabis during pregnancy (pOR=2.02: 1.27 to 3.21). Conclusions and relevance: Use of cannabis during pregnancy may increase adverse outcomes for women and their neonates. As use of cannabis gains social acceptance, pregnant women and their medical providers could benefit from health education on potential adverse effects of use of cannabis during pregnancy.
ISSN:
2044-6055; 2044-6055
DOI:
10.1136/bmjopen-2015-009986
Version:
Final published version
Sponsors:
Arizona Department of Health Services, Phoenix, Arizona, USA
Additional Links:
http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2015-009986

Full metadata record

DC FieldValue Language
dc.contributor.authorGunn, J K Len
dc.contributor.authorRosales, C Ben
dc.contributor.authorCenter, K Een
dc.contributor.authorNuñez, Aen
dc.contributor.authorGibson, S Jen
dc.contributor.authorChrist, Cen
dc.contributor.authorEhiri, J Een
dc.date.accessioned2016-06-29T01:10:30Z-
dc.date.available2016-06-29T01:10:30Z-
dc.date.issued2016-04-05-
dc.identifier.citationPrenatal exposure to cannabis and maternal and child health outcomes: a systematic review and meta-analysis 2016, 6 (4):e009986 BMJ Openen
dc.identifier.issn2044-6055-
dc.identifier.issn2044-6055-
dc.identifier.doi10.1136/bmjopen-2015-009986-
dc.identifier.urihttp://hdl.handle.net/10150/614985-
dc.description.abstractObjective: To assess the effects of use of cannabis during pregnancy on maternal and fetal outcomes. Data sources: 7 electronic databases were searched from inception to 1 April 2014. Studies that investigated the effects of use of cannabis during pregnancy on maternal and fetal outcomes were included. Study selection: Case-control studies, cross-sectional and cohort studies were included. Data extraction and synthesis: Data synthesis was undertaken via systematic review and meta-analysis of available evidence. All review stages were conducted independently by 2 reviewers. Main outcomes and measures: Maternal, fetal and neonatal outcomes up to 6 weeks postpartum after exposure to cannabis. Meta-analyses were conducted on variables that had 3 or more studies that measured an outcome in a consistent manner. Outcomes for which meta-analyses were conducted included: anaemia, birth weight, low birth weight, neonatal length, placement in the neonatal intensive care unit, gestational age, head circumference and preterm birth. Results: 24 studies were included in the review. Results of the meta-analysis demonstrated that women who used cannabis during pregnancy had an increase in the odds of anaemia (pooled OR (pOR)=1.36: 95% CI 1.10 to 1.69) compared with women who did not use cannabis during pregnancy. Infants exposed to cannabis in utero had a decrease in birth weight (low birth weight pOR=1.77: 95% CI 1.04 to 3.01; pooled mean difference (pMD) for birth weight=109.42 g: 38.72 to 180.12) compared with infants whose mothers did not use cannabis during pregnancy. Infants exposed to cannabis in utero were also more likely to need placement in the neonatal intensive care unit compared with infants whose mothers did not use cannabis during pregnancy (pOR=2.02: 1.27 to 3.21). Conclusions and relevance: Use of cannabis during pregnancy may increase adverse outcomes for women and their neonates. As use of cannabis gains social acceptance, pregnant women and their medical providers could benefit from health education on potential adverse effects of use of cannabis during pregnancy.en
dc.description.sponsorshipArizona Department of Health Services, Phoenix, Arizona, USAen
dc.language.isoenen
dc.publisherBMJ PUBLISHING GROUPen
dc.relation.urlhttp://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2015-009986en
dc.rightsThis is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.en
dc.titlePrenatal exposure to cannabis and maternal and child health outcomes: a systematic review and meta-analysisen
dc.typeArticleen
dc.contributor.departmentUniv Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Dept Epidemiol & Biostaten
dc.contributor.departmentUniv Arizona, Dept Obstet & Gynecolen
dc.contributor.departmentUniv Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Arizona Hlth Sci Liben
dc.contributor.departmentUniv Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Dept Hlth Promot Scien
dc.identifier.journalBMJ Openen
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen
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