Associations Between Serum Vitamin D and Adverse Pathology in Men Undergoing Radical Prostatectomy

Persistent Link:
http://hdl.handle.net/10150/614756
Title:
Associations Between Serum Vitamin D and Adverse Pathology in Men Undergoing Radical Prostatectomy
Author:
Nyame, Y. A.; Murphy, A. B.; Bowen, D. K.; Jordan, G.; Batai, K.; Dixon, M.; Hollowell, C. M. P.; Kielb, S.; Meeks, J. J.; Gann, P. H.; Macias, V.; Kajdacsy-Balla, A.; Catalona, W. J.; Kittles, R.
Affiliation:
Univ Arizona
Issue Date:
2016-02-22
Publisher:
AMER SOC CLINICAL ONCOLOGY
Citation:
Associations Between Serum Vitamin D and Adverse Pathology in Men Undergoing Radical Prostatectomy 2016, 34 (12):1345 Journal of Clinical Oncology
Journal:
Journal of Clinical Oncology
Rights:
© 2016 by American Society of Clinical Oncology
Collection Information:
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
Abstract:
Purpose Lower serum vitamin D levels have been associated with an increased risk of aggressive prostate cancer. Among men with localized prostate cancer, especially with low-or intermediate-risk disease, vitamin D may serve as an important biomarker of disease aggression. The aim of this study was to assess the relationship between adverse pathology at the time of radical prostatectomy and serum 25-hydroxyvitamin D (25-OH D) levels. Methods This cross-sectional study was carried out from 2009 to 2014, nested within a large epidemiologic study of 1,760 healthy controls and men undergoing prostate cancer screening. In total, 190 men underwent radical prostatectomy in the cohort. Adverse pathology was defined as the presence of primary Gleason 4 or any Gleason 5 disease, or extraprostatic extension. Descriptive and multivariate analyses were performed to assess the relationship between 25-OH D and adverse pathology at the time of prostatectomy. Results Eighty-seven men (45.8%) in this cohort demonstrated adverse pathology at radical prostatectomy. The median age in the cohort was 64.0 years (interquartile range, 59.0 to 67.0). On univariate analysis, men with adverse pathology at radical prostatectomy demonstrated lower median serum 25-OH D (22.7 v 27.0 ng/mL, P = .007) compared with their counterparts. On multivariate analysis, controlling for age, serum prostate specific antigen, and abnormal digital rectal examination, serum 25-OH D less than 30 ng/mL was associated with increased odds of adverse pathology (odds ratio, 2.64; 95% CI, 1.25 to 5.59; P = .01). Conclusion Insufficiency/deficiency of serum 25-OH D is associated with increased odds of adverse pathology in men with localized disease undergoing radical prostatectomy. Serum 25-OH D may serve as a useful biomarker in prostate cancer aggressiveness, which deserves continued study. (C) 2016 by American Society of Clinical Oncology
Note:
"6 months embargo"
ISSN:
0732-183X; 1527-7755
DOI:
10.1200/JCO.2015.65.1463
Keywords:
CANCER PREVENTION TRIAL; LOW-RISK; ACTIVE SURVEILLANCE; AFRICAN-AMERICAN; ANTIGEN LEVELS; LNCAP CELLS; BIOPSY; CALCITRIOL; OUTCOMES; D-3
Version:
Final published version
Sponsors:
Supported by a grant from the US Department of Defense W81XWH-10-1-0532 pd22E (A.B.M.), and the following National Institutes of Health grants: 1R01MD007105-01 (R.K.); IK2CX000926-01 (A.B.M.), and P50 CA090386-10S1 (W.J.C.).
Additional Links:
http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2015.65.1463

Full metadata record

DC FieldValue Language
dc.contributor.authorNyame, Y. A.en
dc.contributor.authorMurphy, A. B.en
dc.contributor.authorBowen, D. K.en
dc.contributor.authorJordan, G.en
dc.contributor.authorBatai, K.en
dc.contributor.authorDixon, M.en
dc.contributor.authorHollowell, C. M. P.en
dc.contributor.authorKielb, S.en
dc.contributor.authorMeeks, J. J.en
dc.contributor.authorGann, P. H.en
dc.contributor.authorMacias, V.en
dc.contributor.authorKajdacsy-Balla, A.en
dc.contributor.authorCatalona, W. J.en
dc.contributor.authorKittles, R.en
dc.date.accessioned2016-06-24T22:43:47Z-
dc.date.available2016-06-24T22:43:47Z-
dc.date.issued2016-02-22-
dc.identifier.citationAssociations Between Serum Vitamin D and Adverse Pathology in Men Undergoing Radical Prostatectomy 2016, 34 (12):1345 Journal of Clinical Oncologyen
dc.identifier.issn0732-183X-
dc.identifier.issn1527-7755-
dc.identifier.doi10.1200/JCO.2015.65.1463-
dc.identifier.urihttp://hdl.handle.net/10150/614756-
dc.description.abstractPurpose Lower serum vitamin D levels have been associated with an increased risk of aggressive prostate cancer. Among men with localized prostate cancer, especially with low-or intermediate-risk disease, vitamin D may serve as an important biomarker of disease aggression. The aim of this study was to assess the relationship between adverse pathology at the time of radical prostatectomy and serum 25-hydroxyvitamin D (25-OH D) levels. Methods This cross-sectional study was carried out from 2009 to 2014, nested within a large epidemiologic study of 1,760 healthy controls and men undergoing prostate cancer screening. In total, 190 men underwent radical prostatectomy in the cohort. Adverse pathology was defined as the presence of primary Gleason 4 or any Gleason 5 disease, or extraprostatic extension. Descriptive and multivariate analyses were performed to assess the relationship between 25-OH D and adverse pathology at the time of prostatectomy. Results Eighty-seven men (45.8%) in this cohort demonstrated adverse pathology at radical prostatectomy. The median age in the cohort was 64.0 years (interquartile range, 59.0 to 67.0). On univariate analysis, men with adverse pathology at radical prostatectomy demonstrated lower median serum 25-OH D (22.7 v 27.0 ng/mL, P = .007) compared with their counterparts. On multivariate analysis, controlling for age, serum prostate specific antigen, and abnormal digital rectal examination, serum 25-OH D less than 30 ng/mL was associated with increased odds of adverse pathology (odds ratio, 2.64; 95% CI, 1.25 to 5.59; P = .01). Conclusion Insufficiency/deficiency of serum 25-OH D is associated with increased odds of adverse pathology in men with localized disease undergoing radical prostatectomy. Serum 25-OH D may serve as a useful biomarker in prostate cancer aggressiveness, which deserves continued study. (C) 2016 by American Society of Clinical Oncologyen
dc.description.sponsorshipSupported by a grant from the US Department of Defense W81XWH-10-1-0532 pd22E (A.B.M.), and the following National Institutes of Health grants: 1R01MD007105-01 (R.K.); IK2CX000926-01 (A.B.M.), and P50 CA090386-10S1 (W.J.C.).en
dc.language.isoenen
dc.publisherAMER SOC CLINICAL ONCOLOGYen
dc.relation.urlhttp://jco.ascopubs.org/cgi/doi/10.1200/JCO.2015.65.1463en
dc.rights© 2016 by American Society of Clinical Oncologyen
dc.subjectCANCER PREVENTION TRIALen
dc.subjectLOW-RISKen
dc.subjectACTIVE SURVEILLANCEen
dc.subjectAFRICAN-AMERICANen
dc.subjectANTIGEN LEVELSen
dc.subjectLNCAP CELLSen
dc.subjectBIOPSYen
dc.subjectCALCITRIOLen
dc.subjectOUTCOMESen
dc.subjectD-3en
dc.titleAssociations Between Serum Vitamin D and Adverse Pathology in Men Undergoing Radical Prostatectomyen
dc.typeArticleen
dc.contributor.departmentUniv Arizonaen
dc.identifier.journalJournal of Clinical Oncologyen
dc.description.note"6 months embargo"en
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen
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