Reactive oxygen species–associated molecular signature predicts survival in patients with sepsis

Persistent Link:
http://hdl.handle.net/10150/614751
Title:
Reactive oxygen species–associated molecular signature predicts survival in patients with sepsis
Author:
Bime, Christian; Zhou, Tong; Wang, Ting; Slepian, Marvin J.; Garcia, Joe G. N.; Hecker, Louise
Affiliation:
Univ Arizona, Dept Med; Univ Arizona, Dept Biomed Engn
Issue Date:
2016-06
Publisher:
UNIV CHICAGO PRESS
Citation:
Reactive oxygen species–associated molecular signature predicts survival in patients with sepsis 2016, 6 (2):196 Pulmonary Circulation
Journal:
Pulmonary Circulation
Rights:
© 2016 by the Pulmonary Vascular Research Institute. All rights reserved.
Collection Information:
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
Abstract:
Sepsis-related multiple organ dysfunction syndrome is a leading cause of death in intensive care units. There is overwhelming evidence that oxidative stress plays a significant role in the pathogenesis of sepsis-associated multiple organ failure; however, reactive oxygen species (ROS)-associated biomarkers and/or diagnostics that define mortality or predict survival in sepsis are lacking. Lung or peripheral blood gene expression analysis has gained increasing recognition as a potential prognostic and/or diagnostic tool. The objective of this study was to identify ROS-associated biomarkers predictive of survival in patients with sepsis. In-silico analyses of expression profiles allowed the identification of a 21-gene ROS-associated molecular signature that predicts survival in sepsis patients. Importantly, this signature performed well in a validation cohort consisting of sepsis patients aggregated from distinct patient populations recruited from different sites. Our signature outperforms randomly generated signatures of the same signature gene size. Our findings further validate the critical role of ROSs in the pathogenesis of sepsis and provide a novel gene signature that predicts survival in sepsis patients. These results also highlight the utility of peripheral blood molecular signatures as biomarkers for predicting mortality risk in patients with sepsis, which could facilitate the development of personalized therapies.
Note:
On an institutional repository or open access repository after 12 months embargo.
ISSN:
2045-8932; 2045-8940
DOI:
10.1086/685547
Keywords:
microarray; gene expression; reactive oxygen species; sepsis
Version:
Final published version
Sponsors:
Veterans Administration Health System grant [1IK2BX001477]; National Institutes of Health [R01HL91899]
Additional Links:
http://www.journals.uchicago.edu/doi/10.1086/685547

Full metadata record

DC FieldValue Language
dc.contributor.authorBime, Christianen
dc.contributor.authorZhou, Tongen
dc.contributor.authorWang, Tingen
dc.contributor.authorSlepian, Marvin J.en
dc.contributor.authorGarcia, Joe G. N.en
dc.contributor.authorHecker, Louiseen
dc.date.accessioned2016-06-25T01:38:46Z-
dc.date.available2016-06-25T01:38:46Z-
dc.date.issued2016-06-
dc.identifier.citationReactive oxygen species–associated molecular signature predicts survival in patients with sepsis 2016, 6 (2):196 Pulmonary Circulationen
dc.identifier.issn2045-8932-
dc.identifier.issn2045-8940-
dc.identifier.doi10.1086/685547-
dc.identifier.urihttp://hdl.handle.net/10150/614751-
dc.description.abstractSepsis-related multiple organ dysfunction syndrome is a leading cause of death in intensive care units. There is overwhelming evidence that oxidative stress plays a significant role in the pathogenesis of sepsis-associated multiple organ failure; however, reactive oxygen species (ROS)-associated biomarkers and/or diagnostics that define mortality or predict survival in sepsis are lacking. Lung or peripheral blood gene expression analysis has gained increasing recognition as a potential prognostic and/or diagnostic tool. The objective of this study was to identify ROS-associated biomarkers predictive of survival in patients with sepsis. In-silico analyses of expression profiles allowed the identification of a 21-gene ROS-associated molecular signature that predicts survival in sepsis patients. Importantly, this signature performed well in a validation cohort consisting of sepsis patients aggregated from distinct patient populations recruited from different sites. Our signature outperforms randomly generated signatures of the same signature gene size. Our findings further validate the critical role of ROSs in the pathogenesis of sepsis and provide a novel gene signature that predicts survival in sepsis patients. These results also highlight the utility of peripheral blood molecular signatures as biomarkers for predicting mortality risk in patients with sepsis, which could facilitate the development of personalized therapies.en
dc.description.sponsorshipVeterans Administration Health System grant [1IK2BX001477]; National Institutes of Health [R01HL91899]en
dc.language.isoenen
dc.publisherUNIV CHICAGO PRESSen
dc.relation.urlhttp://www.journals.uchicago.edu/doi/10.1086/685547en
dc.rights© 2016 by the Pulmonary Vascular Research Institute. All rights reserved.en
dc.subjectmicroarrayen
dc.subjectgene expressionen
dc.subjectreactive oxygen speciesen
dc.subjectsepsisen
dc.titleReactive oxygen species–associated molecular signature predicts survival in patients with sepsisen
dc.typeArticleen
dc.contributor.departmentUniv Arizona, Dept Meden
dc.contributor.departmentUniv Arizona, Dept Biomed Engnen
dc.identifier.journalPulmonary Circulationen
dc.description.noteOn an institutional repository or open access repository after 12 months embargo.en
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen
All Items in UA Campus Repository are protected by copyright, with all rights reserved, unless otherwise indicated.