Microfluidic Devices for Terahertz Spectroscopy of Live Cells Toward Lab-on-a-Chip Applications

Persistent Link:
http://hdl.handle.net/10150/614745
Title:
Microfluidic Devices for Terahertz Spectroscopy of Live Cells Toward Lab-on-a-Chip Applications
Author:
Tang, Qi ( 0000-0002-4260-7092 ) ; Liang, Min; Lu, Yi; Wong, Pak; Wilmink, Gerald; Zhang, Donna; Xin, Hao
Affiliation:
Univ Arizona, Dept Elect & Comp Engn; Univ Arizona, Coll Pharm
Issue Date:
2016-04-04
Publisher:
MDPI AG
Citation:
Microfluidic Devices for Terahertz Spectroscopy of Live Cells Toward Lab-on-a-Chip Applications 2016, 16 (4):476 Sensors
Journal:
Sensors
Rights:
© 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
Collection Information:
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
Abstract:
THz spectroscopy is an emerging technique for studying the dynamics and interactions of cells and biomolecules, but many practical challenges still remain in experimental studies. We present a prototype of simple and inexpensive cell-trapping microfluidic chip for THz spectroscopic study of live cells. Cells are transported, trapped and concentrated into the THz exposure region by applying an AC bias signal while the chip maintains a steady temperature at 37 degrees C by resistive heating. We conduct some preliminary experiments on E. coli and T-cell solution and compare the transmission spectra of empty channels, channels filled with aqueous media only, and channels filled with aqueous media with un-concentrated and concentrated cells.
ISSN:
1424-8220
DOI:
10.3390/s16040476
Keywords:
cell trapping; lab-on-a-chip; microfluidics; THz spectroscopy
Version:
Final published version
Sponsors:
This research was partly supported by a national research council research associateship award at Air Force Research Laboratory, Radio Frequency Bioeffects Branch, Fort Sam, Houston, TX, USA. The authors are very grateful for the support from Dr. Tingting Liu, and Dr. Abram Young.
Additional Links:
http://www.mdpi.com/1424-8220/16/4/476

Full metadata record

DC FieldValue Language
dc.contributor.authorTang, Qien
dc.contributor.authorLiang, Minen
dc.contributor.authorLu, Yien
dc.contributor.authorWong, Paken
dc.contributor.authorWilmink, Geralden
dc.contributor.authorZhang, Donnaen
dc.contributor.authorXin, Haoen
dc.date.accessioned2016-06-24T23:19:31Z-
dc.date.available2016-06-24T23:19:31Z-
dc.date.issued2016-04-04-
dc.identifier.citationMicrofluidic Devices for Terahertz Spectroscopy of Live Cells Toward Lab-on-a-Chip Applications 2016, 16 (4):476 Sensorsen
dc.identifier.issn1424-8220-
dc.identifier.doi10.3390/s16040476-
dc.identifier.urihttp://hdl.handle.net/10150/614745-
dc.description.abstractTHz spectroscopy is an emerging technique for studying the dynamics and interactions of cells and biomolecules, but many practical challenges still remain in experimental studies. We present a prototype of simple and inexpensive cell-trapping microfluidic chip for THz spectroscopic study of live cells. Cells are transported, trapped and concentrated into the THz exposure region by applying an AC bias signal while the chip maintains a steady temperature at 37 degrees C by resistive heating. We conduct some preliminary experiments on E. coli and T-cell solution and compare the transmission spectra of empty channels, channels filled with aqueous media only, and channels filled with aqueous media with un-concentrated and concentrated cells.en
dc.description.sponsorshipThis research was partly supported by a national research council research associateship award at Air Force Research Laboratory, Radio Frequency Bioeffects Branch, Fort Sam, Houston, TX, USA. The authors are very grateful for the support from Dr. Tingting Liu, and Dr. Abram Young.en
dc.language.isoenen
dc.publisherMDPI AGen
dc.relation.urlhttp://www.mdpi.com/1424-8220/16/4/476en
dc.rights© 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).en
dc.subjectcell trappingen
dc.subjectlab-on-a-chipen
dc.subjectmicrofluidicsen
dc.subjectTHz spectroscopyen
dc.titleMicrofluidic Devices for Terahertz Spectroscopy of Live Cells Toward Lab-on-a-Chip Applicationsen
dc.typeArticleen
dc.contributor.departmentUniv Arizona, Dept Elect & Comp Engnen
dc.contributor.departmentUniv Arizona, Coll Pharmen
dc.identifier.journalSensorsen
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen
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