Predictability of Vancomycin Trough Concentrations Using Five Predictive Methods

Persistent Link:
http://hdl.handle.net/10150/614588
Title:
Predictability of Vancomycin Trough Concentrations Using Five Predictive Methods
Author:
Gowler, Aimee; Murphy, John
Affiliation:
College of Pharmacy, The University of Arizona
Issue Date:
2011
Rights:
Copyright © is held by the author.
Collection Information:
This item is part of the Pharmacy Student Research Projects collection, made available by the College of Pharmacy and the University Libraries at the University of Arizona. For more information about items in this collection, please contact Jennifer Martin, Associate Librarian and Clinical Instructor, Pharmacy Practice and Science, jenmartin@email.arizona.edu.
Publisher:
The University of Arizona.
Abstract:
OBJECTIVES: Five methods for estimating vancomycin pharmacokinetic parameters were studied to determine the accuracy of each method in predicting vancomycin concentration. METHODS Patient vancomycin pharmacokinetic data from a prior study were retrospectively reviewed and used in five methods to calculate vancomycin clearance and volume of distribution in order to determine the accuracy in prediction of the measured value. RESULTS: The coefficients of determination ranged from 0.167 to 0.224, bias ranged from -5.18 to 2.13, and precision ranged from 5.98 to 7.64. The Buelga method had the highest percentage of predictions within 2.5 and 5 mg/L of the measured trough at 42% and 65% respectively, while the Thomson method had the highest percentage of predictions within 50% of the measured trough at 52%. The highest percentage of predictions within 25% of the measured trough were found with both the Thomson and Yasuhara method at 29%. CONCLUSION: There was wide variation in the prediction of vancomycin trough concentrations from the five methods for estimating vancomycin pharmacokinetic parameters. None of the methods provided adequate reliability to recommend discontinuation of therapeutic drug monitoring for vancomycin.
Description:
Class of 2011 Abstract
Keywords:
vancomycin; concentrations; methods; vancomycin pharmacokinetic
MeSH Subjects:
Vancomycin
Advisor:
Murphy, John

Full metadata record

DC FieldValue Language
dc.contributor.advisorMurphy, Johnen
dc.contributor.authorGowler, Aimeeen
dc.contributor.authorMurphy, Johnen
dc.date.accessioned2016-06-24T15:32:02Z-
dc.date.available2016-06-24T15:32:02Z-
dc.date.issued2011-
dc.identifier.urihttp://hdl.handle.net/10150/614588-
dc.descriptionClass of 2011 Abstracten
dc.description.abstractOBJECTIVES: Five methods for estimating vancomycin pharmacokinetic parameters were studied to determine the accuracy of each method in predicting vancomycin concentration. METHODS Patient vancomycin pharmacokinetic data from a prior study were retrospectively reviewed and used in five methods to calculate vancomycin clearance and volume of distribution in order to determine the accuracy in prediction of the measured value. RESULTS: The coefficients of determination ranged from 0.167 to 0.224, bias ranged from -5.18 to 2.13, and precision ranged from 5.98 to 7.64. The Buelga method had the highest percentage of predictions within 2.5 and 5 mg/L of the measured trough at 42% and 65% respectively, while the Thomson method had the highest percentage of predictions within 50% of the measured trough at 52%. The highest percentage of predictions within 25% of the measured trough were found with both the Thomson and Yasuhara method at 29%. CONCLUSION: There was wide variation in the prediction of vancomycin trough concentrations from the five methods for estimating vancomycin pharmacokinetic parameters. None of the methods provided adequate reliability to recommend discontinuation of therapeutic drug monitoring for vancomycin.en
dc.language.isoen_USen
dc.publisherThe University of Arizona.en
dc.rightsCopyright © is held by the author.en
dc.subjectvancomycinen
dc.subjectconcentrationsen
dc.subjectmethodsen
dc.subjectvancomycin pharmacokineticen
dc.subject.meshVancomycin-
dc.titlePredictability of Vancomycin Trough Concentrations Using Five Predictive Methodsen_US
dc.typetexten
dc.typeElectronic Reporten
dc.contributor.departmentCollege of Pharmacy, The University of Arizonaen
dc.description.collectioninformationThis item is part of the Pharmacy Student Research Projects collection, made available by the College of Pharmacy and the University Libraries at the University of Arizona. For more information about items in this collection, please contact Jennifer Martin, Associate Librarian and Clinical Instructor, Pharmacy Practice and Science, jenmartin@email.arizona.edu.en
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