Persistent Link:
http://hdl.handle.net/10150/614512
Title:
Stability of Extemporaneously Prepared Captopril Solution
Author:
Park, Sean; Wong, Basil; Lee, David
Affiliation:
College of Pharmacy, The University of Arizona
Issue Date:
2012
Rights:
Copyright © is held by the author.
Collection Information:
This item is part of the Pharmacy Student Research Projects collection, made available by the College of Pharmacy and the University Libraries at the University of Arizona. For more information about items in this collection, please contact Jennifer Martin, Associate Librarian and Clinical Instructor, Pharmacy Practice and Science, jenmartin@email.arizona.edu.
Publisher:
The University of Arizona.
Abstract:
Specific Aims: Assess the stability and sterility of various extemporaneously compounded captopril solution in different storage conditions. Methods: Extemporaneously prepared captopril standards and solutions tested in a high performance liquid chromatography instrument collected data on stability. In addition, physical appearance, bacterial growth and pH data were also collected. Main Results: Stability data was assessed with extemporaneously prepared captopril solutions prepared with standardized captopril powder, captopril tablets and captopril tablets with ascorbic acid included. Stability was defined as retention of at least 90% of the initial captopril concentration. Overall, all preparations were stable when stored at 4°C but only the tablet preparation was stable when stored at 25°C and 40°C. No bacterial growth was observed with any of the captopril solutions. Conclusions: Extemporaneously prepared captopril solution appears to have a shelf-life of at least 28 days when stored at 4°C.
Description:
Class of 2012 Abstract
Keywords:
Stability; Extemporaneously; Captopril Solution
Advisor:
Lee, David

Full metadata record

DC FieldValue Language
dc.contributor.advisorLee, Daviden
dc.contributor.authorPark, Seanen
dc.contributor.authorWong, Basilen
dc.contributor.authorLee, Daviden
dc.date.accessioned2016-06-23T20:18:27Z-
dc.date.available2016-06-23T20:18:27Z-
dc.date.issued2012-
dc.identifier.urihttp://hdl.handle.net/10150/614512-
dc.descriptionClass of 2012 Abstracten
dc.description.abstractSpecific Aims: Assess the stability and sterility of various extemporaneously compounded captopril solution in different storage conditions. Methods: Extemporaneously prepared captopril standards and solutions tested in a high performance liquid chromatography instrument collected data on stability. In addition, physical appearance, bacterial growth and pH data were also collected. Main Results: Stability data was assessed with extemporaneously prepared captopril solutions prepared with standardized captopril powder, captopril tablets and captopril tablets with ascorbic acid included. Stability was defined as retention of at least 90% of the initial captopril concentration. Overall, all preparations were stable when stored at 4°C but only the tablet preparation was stable when stored at 25°C and 40°C. No bacterial growth was observed with any of the captopril solutions. Conclusions: Extemporaneously prepared captopril solution appears to have a shelf-life of at least 28 days when stored at 4°C.en
dc.language.isoen_USen
dc.publisherThe University of Arizona.en
dc.rightsCopyright © is held by the author.en
dc.subjectStabilityen
dc.subjectExtemporaneouslyen
dc.subjectCaptopril Solutionen
dc.titleStability of Extemporaneously Prepared Captopril Solutionen_US
dc.typetexten
dc.typeElectronic Reporten
dc.contributor.departmentCollege of Pharmacy, The University of Arizonaen
dc.description.collectioninformationThis item is part of the Pharmacy Student Research Projects collection, made available by the College of Pharmacy and the University Libraries at the University of Arizona. For more information about items in this collection, please contact Jennifer Martin, Associate Librarian and Clinical Instructor, Pharmacy Practice and Science, jenmartin@email.arizona.edu.en
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