Stenotrophomonas Maltophilia and Time to Appropriate Antibiotic Therapy

Persistent Link:
http://hdl.handle.net/10150/614176
Title:
Stenotrophomonas Maltophilia and Time to Appropriate Antibiotic Therapy
Author:
Kwong, Amelia; Zhu, Jenny; Matthias, Kathryn
Affiliation:
College of Pharmacy, The University of Arizona
Issue Date:
2014
Rights:
Copyright © is held by the author.
Collection Information:
This item is part of the Pharmacy Student Research Projects collection, made available by the College of Pharmacy and the University Libraries at the University of Arizona. For more information about items in this collection, please contact Jennifer Martin, Associate Librarian and Clinical Instructor, Pharmacy Practice and Science, jenmartin@email.arizona.edu.
Publisher:
The University of Arizona.
Abstract:
Specific Aims: Determine time to appropriate therapy for S. maltophilia infection before implementation of mass spec. A second part of this project will evaluate the time to appropriate therapy after implementation of mass spec. The hypothesis is the time to appropriate therapy will decrease by > 2 days after implementation of mass spec. appropriate antibiotic therapy will be based on susceptibility data reported for each isolate of S. maltophilia. Potential appropriate therapy that will be evaluated includes high-dose sulfamethoxazole-trimethoprim (10-20 mg/kg/day based on TMP adjusted for renal function), ticarcillin- clavulanate plus aztreonam, moxifloxacin or levofloxacin, and ceftazidime. Methods: A retrospective chart review was done to evaluate time to identification and time to appropriate therapy for S. maltophilia as baseline data before implementation of mass spectrometry for earlier species identification. Subject selection included all patients between June 1, 2011 through May 31, 2012 with S. Maltophilia isolated from any source while admitted to the University of Arizona Medical Center-University Campus, Tucson, AZ. Patients with initial S. maltophilia isolated from a post-mortem sample or were colonizers were excluded. Main Results: There were 86 subjects included in the study based on inclusion and exclusion criteria. There were 60 subjects that received appropriate therapy for S. maltophilia coverage. The averaged time to initiation of appropriate antibiotic prior to the implementation of mass spectrometer was determined to be 6.5 days. Conclusion: Since S. maltophilia is not susceptible to many antibiotics used as empiric therapy, early identification of the pathogen via mass spectrometry, in addition to pharmacist intervention, may lead to initiation of appropriate antibiotics that is earlier than an average of 6.5 days found in this study.
Description:
Class of 2014 Abstract
Keywords:
Stenotrophomonas maltophilia; therapy; antibiotic
Advisor:
Matthias, Kathryn

Full metadata record

DC FieldValue Language
dc.contributor.advisorMatthias, Kathrynen
dc.contributor.authorKwong, Ameliaen
dc.contributor.authorZhu, Jennyen
dc.contributor.authorMatthias, Kathrynen
dc.date.accessioned2016-06-22T18:36:34Z-
dc.date.available2016-06-22T18:36:34Z-
dc.date.issued2014-
dc.identifier.urihttp://hdl.handle.net/10150/614176-
dc.descriptionClass of 2014 Abstracten
dc.description.abstractSpecific Aims: Determine time to appropriate therapy for S. maltophilia infection before implementation of mass spec. A second part of this project will evaluate the time to appropriate therapy after implementation of mass spec. The hypothesis is the time to appropriate therapy will decrease by > 2 days after implementation of mass spec. appropriate antibiotic therapy will be based on susceptibility data reported for each isolate of S. maltophilia. Potential appropriate therapy that will be evaluated includes high-dose sulfamethoxazole-trimethoprim (10-20 mg/kg/day based on TMP adjusted for renal function), ticarcillin- clavulanate plus aztreonam, moxifloxacin or levofloxacin, and ceftazidime. Methods: A retrospective chart review was done to evaluate time to identification and time to appropriate therapy for S. maltophilia as baseline data before implementation of mass spectrometry for earlier species identification. Subject selection included all patients between June 1, 2011 through May 31, 2012 with S. Maltophilia isolated from any source while admitted to the University of Arizona Medical Center-University Campus, Tucson, AZ. Patients with initial S. maltophilia isolated from a post-mortem sample or were colonizers were excluded. Main Results: There were 86 subjects included in the study based on inclusion and exclusion criteria. There were 60 subjects that received appropriate therapy for S. maltophilia coverage. The averaged time to initiation of appropriate antibiotic prior to the implementation of mass spectrometer was determined to be 6.5 days. Conclusion: Since S. maltophilia is not susceptible to many antibiotics used as empiric therapy, early identification of the pathogen via mass spectrometry, in addition to pharmacist intervention, may lead to initiation of appropriate antibiotics that is earlier than an average of 6.5 days found in this study.en
dc.language.isoen_USen
dc.publisherThe University of Arizona.en
dc.rightsCopyright © is held by the author.en
dc.subjectStenotrophomonas maltophiliaen
dc.subjecttherapyen
dc.subjectantibioticen
dc.titleStenotrophomonas Maltophilia and Time to Appropriate Antibiotic Therapyen_US
dc.typetexten
dc.typeElectronic Reporten
dc.contributor.departmentCollege of Pharmacy, The University of Arizonaen
dc.description.collectioninformationThis item is part of the Pharmacy Student Research Projects collection, made available by the College of Pharmacy and the University Libraries at the University of Arizona. For more information about items in this collection, please contact Jennifer Martin, Associate Librarian and Clinical Instructor, Pharmacy Practice and Science, jenmartin@email.arizona.edu.en
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