Effects of Azithromycin and Moxifloxacin Used Alone and Concomitantly With QTc Prolonging Medications on the QTc Interval

Persistent Link:
http://hdl.handle.net/10150/614126
Title:
Effects of Azithromycin and Moxifloxacin Used Alone and Concomitantly With QTc Prolonging Medications on the QTc Interval
Author:
Johannesmeyer, Herman; Moghimi, Parissa; Parekh, Hershil; Nix, David
Affiliation:
College of Pharmacy, The University of Arizona
Issue Date:
2015
Rights:
Copyright © is held by the author.
Collection Information:
This item is part of the Pharmacy Student Research Projects collection, made available by the College of Pharmacy and the University Libraries at the University of Arizona. For more information about items in this collection, please contact Jennifer Martin, Associate Librarian and Clinical Instructor, Pharmacy Practice and Science, jenmartin@email.arizona.edu.
Publisher:
The University of Arizona.
Abstract:
Objectives: The goals of this study were to determine how frequently azithromycin and moxifloxacin were used in combination with other drugs that cause QTc prolongation, describe the effects these combinations have on QTc interval length, determine the incidence of QTc prolongation in patients on these medication combinations, and identify risk factors associated with QTc interval prolongations in patients on these medication combinations. Methods: A retrospective chart review was performed on patients who received at least two doses of azithromycin or moxifloxacin. It was noted whether these patients received other medications that prolonged the QTc interval. ECG information was grouped into daily phases depending on whether the patient was at baseline, receiving antibiotic therapy, QTc prolonging medication therapy, or concomitant therapy. These data were compared using a repeated measures ANOVA. Results: Patients received concomitant antibiotic-QTc prolong medication therapy in 70% of cases analyzed. In all patients on concomitant therapy there was no significant difference in any measured ECG data (all p-values > 0.26). In those who were on azithromycin and experienced QTc prolongation there was a significant difference in RR interval length (p=0.034). In those that experienced QTc prolongation on moxifloxacin there was a significant difference in QT (p=0.0033) and QTcF (p=0.0089) length. Conclusions: These medication combinations are used frequently in the hospital. These medications may not increase the QTc interval length in the general population but more research is warranted in this area to confirm this finding.
Description:
Class of 2015 Abstract
Keywords:
azithromycin; moxifloxacin; QTc prolongation; interval
Advisor:
Nix, David

Full metadata record

DC FieldValue Language
dc.contributor.advisorNix, Daviden
dc.contributor.authorJohannesmeyer, Hermanen
dc.contributor.authorMoghimi, Parissaen
dc.contributor.authorParekh, Hershilen
dc.contributor.authorNix, Daviden
dc.date.accessioned2016-06-22T17:01:54Z-
dc.date.available2016-06-22T17:01:54Z-
dc.date.issued2015-
dc.identifier.urihttp://hdl.handle.net/10150/614126-
dc.descriptionClass of 2015 Abstracten
dc.description.abstractObjectives: The goals of this study were to determine how frequently azithromycin and moxifloxacin were used in combination with other drugs that cause QTc prolongation, describe the effects these combinations have on QTc interval length, determine the incidence of QTc prolongation in patients on these medication combinations, and identify risk factors associated with QTc interval prolongations in patients on these medication combinations. Methods: A retrospective chart review was performed on patients who received at least two doses of azithromycin or moxifloxacin. It was noted whether these patients received other medications that prolonged the QTc interval. ECG information was grouped into daily phases depending on whether the patient was at baseline, receiving antibiotic therapy, QTc prolonging medication therapy, or concomitant therapy. These data were compared using a repeated measures ANOVA. Results: Patients received concomitant antibiotic-QTc prolong medication therapy in 70% of cases analyzed. In all patients on concomitant therapy there was no significant difference in any measured ECG data (all p-values > 0.26). In those who were on azithromycin and experienced QTc prolongation there was a significant difference in RR interval length (p=0.034). In those that experienced QTc prolongation on moxifloxacin there was a significant difference in QT (p=0.0033) and QTcF (p=0.0089) length. Conclusions: These medication combinations are used frequently in the hospital. These medications may not increase the QTc interval length in the general population but more research is warranted in this area to confirm this finding.en
dc.language.isoen_USen
dc.publisherThe University of Arizona.en
dc.rightsCopyright © is held by the author.en
dc.subjectazithromycinen
dc.subjectmoxifloxacinen
dc.subjectQTc prolongationen
dc.subjectintervalen
dc.titleEffects of Azithromycin and Moxifloxacin Used Alone and Concomitantly With QTc Prolonging Medications on the QTc Intervalen_US
dc.typetexten
dc.typeElectronic Reporten
dc.contributor.departmentCollege of Pharmacy, The University of Arizonaen
dc.description.collectioninformationThis item is part of the Pharmacy Student Research Projects collection, made available by the College of Pharmacy and the University Libraries at the University of Arizona. For more information about items in this collection, please contact Jennifer Martin, Associate Librarian and Clinical Instructor, Pharmacy Practice and Science, jenmartin@email.arizona.edu.en
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