Evaluation of Time to Appropriate Therapy for Stenotrophomonas Maltophilia Infection Using Rapid Species Identification

Persistent Link:
http://hdl.handle.net/10150/614102
Title:
Evaluation of Time to Appropriate Therapy for Stenotrophomonas Maltophilia Infection Using Rapid Species Identification
Author:
Bastani, Rod; Condon, Amanda; Nix, David; Matthias, Kathryn
Affiliation:
College of Pharmacy, The University of Arizona
Issue Date:
2015
Rights:
Copyright © is held by the author.
Collection Information:
This item is part of the Pharmacy Student Research Projects collection, made available by the College of Pharmacy and the University Libraries at the University of Arizona. For more information about items in this collection, please contact Jennifer Martin, Associate Librarian and Clinical Instructor, Pharmacy Practice and Science, jenmartin@email.arizona.edu.
Publisher:
The University of Arizona.
Abstract:
Objectives: Stenotrophomonas maltophilia is considered one of the most intrinsically resistant opportunistic infections in the hospital setting. Immunocompromised patients are at a significant risk for nosocomial S. maltophilia infection. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry can quickly identify S. maltophilia. This study sought to determine the median and range of time to appropriate therapy of S. maltophilia infections after implementation of MALDI-TOF-MS for rapid species identification. Methods: A retrospective electronic medical record review of patients admitted to UAMC-UC during the study period was utilized to determine time to appropriate therapy. Positive cultures for S. maltophilia were identified by the microbiology laboratory database and assessed for inclusion in the study. Demographic information, time of culture, time to appropriate therapy, and isolate susceptibilities were collected using a data extraction tool. Variables were assessed with medians and ranges. Results: The average time to appropriate therapy was 3.4 days with a median of 3 days (range 0-21). Most isolates were susceptible to sulfamethoxazole-trimethoprim and levofloxacin and resistant to ceftazidime. Of the 20 isolates resistant to sulfamethoxazole-trimethoprim, 14 were susceptible to levofloxacin. Only one isolate was resistant to all four drugs. Immunocompromised patients accounted for only 12% of the study population. Conclusions: After implementation of MALDI-TOF MS, the median time to appropriate therapy in S. maltophilia infection was 3 days. Rapid species identification can lead to a quicker time to appropriate therapy, which is essential for effective treatment of S. maltophilia infection.
Description:
Class of 2015 Abstract
Keywords:
Stenotrophomonas maltophilia; therapy; infection; rapid species
Advisor:
Nix, David; Matthias, Kathryn

Full metadata record

DC FieldValue Language
dc.contributor.advisorNix, Daviden
dc.contributor.advisorMatthias, Kathrynen
dc.contributor.authorBastani, Roden
dc.contributor.authorCondon, Amandaen
dc.contributor.authorNix, Daviden
dc.contributor.authorMatthias, Kathrynen
dc.date.accessioned2016-06-22T15:55:22Z-
dc.date.available2016-06-22T15:55:22Z-
dc.date.issued2015-
dc.identifier.urihttp://hdl.handle.net/10150/614102-
dc.descriptionClass of 2015 Abstracten
dc.description.abstractObjectives: Stenotrophomonas maltophilia is considered one of the most intrinsically resistant opportunistic infections in the hospital setting. Immunocompromised patients are at a significant risk for nosocomial S. maltophilia infection. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry can quickly identify S. maltophilia. This study sought to determine the median and range of time to appropriate therapy of S. maltophilia infections after implementation of MALDI-TOF-MS for rapid species identification. Methods: A retrospective electronic medical record review of patients admitted to UAMC-UC during the study period was utilized to determine time to appropriate therapy. Positive cultures for S. maltophilia were identified by the microbiology laboratory database and assessed for inclusion in the study. Demographic information, time of culture, time to appropriate therapy, and isolate susceptibilities were collected using a data extraction tool. Variables were assessed with medians and ranges. Results: The average time to appropriate therapy was 3.4 days with a median of 3 days (range 0-21). Most isolates were susceptible to sulfamethoxazole-trimethoprim and levofloxacin and resistant to ceftazidime. Of the 20 isolates resistant to sulfamethoxazole-trimethoprim, 14 were susceptible to levofloxacin. Only one isolate was resistant to all four drugs. Immunocompromised patients accounted for only 12% of the study population. Conclusions: After implementation of MALDI-TOF MS, the median time to appropriate therapy in S. maltophilia infection was 3 days. Rapid species identification can lead to a quicker time to appropriate therapy, which is essential for effective treatment of S. maltophilia infection.en
dc.language.isoen_USen
dc.publisherThe University of Arizona.en
dc.rightsCopyright © is held by the author.en
dc.subjectStenotrophomonas maltophiliaen
dc.subjecttherapyen
dc.subjectinfectionen
dc.subjectrapid speciesen
dc.titleEvaluation of Time to Appropriate Therapy for Stenotrophomonas Maltophilia Infection Using Rapid Species Identificationen_US
dc.typetexten
dc.typeElectronic Reporten
dc.contributor.departmentCollege of Pharmacy, The University of Arizonaen
dc.description.collectioninformationThis item is part of the Pharmacy Student Research Projects collection, made available by the College of Pharmacy and the University Libraries at the University of Arizona. For more information about items in this collection, please contact Jennifer Martin, Associate Librarian and Clinical Instructor, Pharmacy Practice and Science, jenmartin@email.arizona.edu.en
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