The Effect of Sodium Bicarbonate on the Stability of Phenytoin IV Solutions

Persistent Link:
http://hdl.handle.net/10150/614030
Title:
The Effect of Sodium Bicarbonate on the Stability of Phenytoin IV Solutions
Author:
Hadzic, Ajla; Un, Sophia; Lee, David
Affiliation:
College of Pharmacy, The University of Arizona
Issue Date:
2015
Rights:
Copyright © is held by the author.
Collection Information:
This item is part of the Pharmacy Student Research Projects collection, made available by the College of Pharmacy and the University Libraries at the University of Arizona. For more information about items in this collection, please contact Jennifer Martin, Associate Librarian and Clinical Instructor, Pharmacy Practice and Science, jenmartin@email.arizona.edu.
Publisher:
The University of Arizona.
Abstract:
Objectives: To determine if a change in the amount of sodium bicarbonate (NaHCO3) in 5 different IV solutions will help prevent phenytoin from falling out of solution (i.e. precipitating). Our working hypothesis is that the stability of the phenytoin solution will change with different IV solutions and will increase with increasing the amount of sodium bicarbonate. Methods: A constant amount of phenytoin injection solution was mixed with a constant amount of one IV solution per beaker. Different amounts of alkalizing agents were then added to each phenytoin and IV mixture. Precipitation of the mixtures was observed every 30 minutes for 4 hours, then again in 24 hours. Results: When different IV solutions were added to the phenytoin and alkalizing agent mixture , the pH of the mixture dropped from 10 to 9 independent of the amount of alkalizing agent present in the mixture. All phenytoin mixtures precipitated within 60 minutes; 0.9% NaCl and phenytoin mixture being the one with the most delayed precipitation. Conclusions: Based on the result of this experiment, we rejected both of our specific aim hypotheses. Our hypothesis is rejected because the stability of the phenytoin solution will not change by using different IV solutions or by changing the amount of sodium bicarbonate.
Description:
Class of 2015 Abstract
Keywords:
sodium bicarbonate (NaHCO3); Phenytoin IV Solutions; Stability
Advisor:
Lee, David

Full metadata record

DC FieldValue Language
dc.contributor.advisorLee, Daviden
dc.contributor.authorHadzic, Ajlaen
dc.contributor.authorUn, Sophiaen
dc.contributor.authorLee, Daviden
dc.date.accessioned2016-06-21T22:57:11Z-
dc.date.available2016-06-21T22:57:11Z-
dc.date.issued2015-
dc.identifier.urihttp://hdl.handle.net/10150/614030-
dc.descriptionClass of 2015 Abstracten
dc.description.abstractObjectives: To determine if a change in the amount of sodium bicarbonate (NaHCO3) in 5 different IV solutions will help prevent phenytoin from falling out of solution (i.e. precipitating). Our working hypothesis is that the stability of the phenytoin solution will change with different IV solutions and will increase with increasing the amount of sodium bicarbonate. Methods: A constant amount of phenytoin injection solution was mixed with a constant amount of one IV solution per beaker. Different amounts of alkalizing agents were then added to each phenytoin and IV mixture. Precipitation of the mixtures was observed every 30 minutes for 4 hours, then again in 24 hours. Results: When different IV solutions were added to the phenytoin and alkalizing agent mixture , the pH of the mixture dropped from 10 to 9 independent of the amount of alkalizing agent present in the mixture. All phenytoin mixtures precipitated within 60 minutes; 0.9% NaCl and phenytoin mixture being the one with the most delayed precipitation. Conclusions: Based on the result of this experiment, we rejected both of our specific aim hypotheses. Our hypothesis is rejected because the stability of the phenytoin solution will not change by using different IV solutions or by changing the amount of sodium bicarbonate.en
dc.language.isoen_USen
dc.publisherThe University of Arizona.en
dc.rightsCopyright © is held by the author.en
dc.subjectsodium bicarbonate (NaHCO3)en
dc.subjectPhenytoin IV Solutionsen
dc.subjectStabilityen
dc.titleThe Effect of Sodium Bicarbonate on the Stability of Phenytoin IV Solutionsen_US
dc.typetexten
dc.typeElectronic Reporten
dc.contributor.departmentCollege of Pharmacy, The University of Arizonaen
dc.description.collectioninformationThis item is part of the Pharmacy Student Research Projects collection, made available by the College of Pharmacy and the University Libraries at the University of Arizona. For more information about items in this collection, please contact Jennifer Martin, Associate Librarian and Clinical Instructor, Pharmacy Practice and Science, jenmartin@email.arizona.edu.en
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