Evaluation of the Quality of Amiodarone with Macrolides and Fluoroquinolones Drug-Drug Interactions Reported in the Literature

Persistent Link:
http://hdl.handle.net/10150/614009
Title:
Evaluation of the Quality of Amiodarone with Macrolides and Fluoroquinolones Drug-Drug Interactions Reported in the Literature
Author:
Do, Brian; Patel, Pritesh; Yee, Kevin; Malone, Daniel
Affiliation:
College of Pharmacy, The University of Arizona
Issue Date:
2015
Rights:
Copyright © is held by the author.
Collection Information:
This item is part of the Pharmacy Student Research Projects collection, made available by the College of Pharmacy and the University Libraries at the University of Arizona. For more information about items in this collection, please contact Jennifer Martin, Associate Librarian and Clinical Instructor, Pharmacy Practice and Science, jenmartin@email.arizona.edu.
Publisher:
The University of Arizona.
Abstract:
Objectives: To determine the quality of evidence in the literature reporting the potential effect of QT prolongation and cardiovascular interactions of amiodarone with fluoroquinolones and macrolides. Methods: A thorough database search was conducted utilizing PubMed, Embase, Micromedex, and Facts and Comparison. Studies were eligible if they involved human subjects, original submission in English, and focusing on any drugs within the macrolide class along with amiodarone or any drugs within the fluoroquinolone class along with amiodarone was included. Drug-drug interactions (DDI) within the literature were evaluated using one of two tools: (1) van Roon to assess the quality of randomized controlled studies, and (2) the Drug Interaction Probability Scale (DIPS) to assess case reports. Results: Five case reports were included for evaluation. None of the patients within the case reports were less than 65 years old. Four of the five case reports included ciprofloxacin as part of the proposed drug interaction with amiodarone. The range of DIPS scores were 4-7 with a median score of 6. Conclusions: The evidence purporting this drug-drug interaction is of poor quality and low quantity. Additional studies of high quality must be conducted on the subject of this DDI to provide clinicians the ability to make more informed clinical decisions.
Description:
Class of 2015 Abstract
Keywords:
amiodarone; macrolides; fluoroquinolones; drug-drug; interactions
Advisor:
Malone, Daniel

Full metadata record

DC FieldValue Language
dc.contributor.advisorMalone, Danielen
dc.contributor.authorDo, Brianen
dc.contributor.authorPatel, Priteshen
dc.contributor.authorYee, Kevinen
dc.contributor.authorMalone, Danielen
dc.date.accessioned2016-06-21T22:48:35Z-
dc.date.available2016-06-21T22:48:35Z-
dc.date.issued2015-
dc.identifier.urihttp://hdl.handle.net/10150/614009-
dc.descriptionClass of 2015 Abstracten
dc.description.abstractObjectives: To determine the quality of evidence in the literature reporting the potential effect of QT prolongation and cardiovascular interactions of amiodarone with fluoroquinolones and macrolides. Methods: A thorough database search was conducted utilizing PubMed, Embase, Micromedex, and Facts and Comparison. Studies were eligible if they involved human subjects, original submission in English, and focusing on any drugs within the macrolide class along with amiodarone or any drugs within the fluoroquinolone class along with amiodarone was included. Drug-drug interactions (DDI) within the literature were evaluated using one of two tools: (1) van Roon to assess the quality of randomized controlled studies, and (2) the Drug Interaction Probability Scale (DIPS) to assess case reports. Results: Five case reports were included for evaluation. None of the patients within the case reports were less than 65 years old. Four of the five case reports included ciprofloxacin as part of the proposed drug interaction with amiodarone. The range of DIPS scores were 4-7 with a median score of 6. Conclusions: The evidence purporting this drug-drug interaction is of poor quality and low quantity. Additional studies of high quality must be conducted on the subject of this DDI to provide clinicians the ability to make more informed clinical decisions.en
dc.language.isoen_USen
dc.publisherThe University of Arizona.en
dc.rightsCopyright © is held by the author.en
dc.subjectamiodaroneen
dc.subjectmacrolidesen
dc.subjectfluoroquinolonesen
dc.subjectdrug-drugen
dc.subjectinteractionsen
dc.titleEvaluation of the Quality of Amiodarone with Macrolides and Fluoroquinolones Drug-Drug Interactions Reported in the Literatureen_US
dc.typetexten
dc.typeElectronic Reporten
dc.contributor.departmentCollege of Pharmacy, The University of Arizonaen
dc.description.collectioninformationThis item is part of the Pharmacy Student Research Projects collection, made available by the College of Pharmacy and the University Libraries at the University of Arizona. For more information about items in this collection, please contact Jennifer Martin, Associate Librarian and Clinical Instructor, Pharmacy Practice and Science, jenmartin@email.arizona.edu.en
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