A NOVEL COMPREHENSIVE ASSESSMENT OF VISUAL DYSFUNCTION IN PARKINSON’S DISEASE

Persistent Link:
http://hdl.handle.net/10150/612956
Title:
A NOVEL COMPREHENSIVE ASSESSMENT OF VISUAL DYSFUNCTION IN PARKINSON’S DISEASE
Author:
GIBLER, HAYLEY LAUREN
Issue Date:
2016
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Parkinson’s disease (PD) is generally characterized by difficulty controlling muscle movements due to the loss of dopaminergic cells in the substantia nigra region of the brain. Additionally, the aggregation protein clusters known as Lewy bodies, otherwise known as phosphorylated 𝛼-synuclein, begins at the brainstem and progresses toward cortical regions of the brain as the disease progresses. 𝛼-synuclein has also been found in the retina of PD patients. PD patients often complain of vision problems, but there is little research in this area. Due to the pattern of 𝛼-synuclein aggregates in the cortical regions and the retina, it is possible that lowerlevel and higher-level visual processing may be affected in patients with PD. This study recruited 31 subjects with PD and 23 control subjects to participate at the Southern Arizona VA Health Care System in Tucson, Arizona. Each patient signed consent forms approved by the SAVAHCS IRB. A series of cognitive tasks that measured the function of the dorsal visual pathway, ventral visual pathway, executive function, low-level vision, general cognition and dexterity were administered to each subject. It was found that subjects with PD have diminished low-level vision, processing in the dorsal visual pathway, general top-down executive function, and motor function.
Type:
text; Electronic Thesis
Degree Name:
B.S.
Degree Level:
Bachelors
Degree Program:
Honors College; Neuroscience & Cognitive Science
Degree Grantor:
University of Arizona
Advisor:
Rapcsak, Steven

Full metadata record

DC FieldValue Language
dc.language.isoen_USen
dc.titleA NOVEL COMPREHENSIVE ASSESSMENT OF VISUAL DYSFUNCTION IN PARKINSON’S DISEASEen_US
dc.creatorGIBLER, HAYLEY LAURENen
dc.contributor.authorGIBLER, HAYLEY LAURENen
dc.date.issued2016-
dc.publisherThe University of Arizona.en
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en
dc.description.abstractParkinson’s disease (PD) is generally characterized by difficulty controlling muscle movements due to the loss of dopaminergic cells in the substantia nigra region of the brain. Additionally, the aggregation protein clusters known as Lewy bodies, otherwise known as phosphorylated 𝛼-synuclein, begins at the brainstem and progresses toward cortical regions of the brain as the disease progresses. 𝛼-synuclein has also been found in the retina of PD patients. PD patients often complain of vision problems, but there is little research in this area. Due to the pattern of 𝛼-synuclein aggregates in the cortical regions and the retina, it is possible that lowerlevel and higher-level visual processing may be affected in patients with PD. This study recruited 31 subjects with PD and 23 control subjects to participate at the Southern Arizona VA Health Care System in Tucson, Arizona. Each patient signed consent forms approved by the SAVAHCS IRB. A series of cognitive tasks that measured the function of the dorsal visual pathway, ventral visual pathway, executive function, low-level vision, general cognition and dexterity were administered to each subject. It was found that subjects with PD have diminished low-level vision, processing in the dorsal visual pathway, general top-down executive function, and motor function.en
dc.typetexten
dc.typeElectronic Thesisen
thesis.degree.nameB.S.en
thesis.degree.levelBachelorsen
thesis.degree.disciplineHonors Collegeen
thesis.degree.disciplineNeuroscience & Cognitive Scienceen
thesis.degree.grantorUniversity of Arizonaen
dc.contributor.advisorRapcsak, Stevenen
All Items in UA Campus Repository are protected by copyright, with all rights reserved, unless otherwise indicated.