CORRESPONDENCE BETWEEN STRUCTURAL AND DYNAMIC PROPERTIES IN A BIOCHEMICAL NETWORK

Persistent Link:
http://hdl.handle.net/10150/612563
Title:
CORRESPONDENCE BETWEEN STRUCTURAL AND DYNAMIC PROPERTIES IN A BIOCHEMICAL NETWORK
Author:
ANDREWS, JOHN EMMET
Issue Date:
2016
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Phenotypic traits are determined by networks of interactions between genes, proteins and enzymes. Structural positions of regulatory mechanisms in the network can determine variability in its elements. Here we examine the topological properties of controls that regulate element expression in a network. If distinct regulatory controls are located at the beginning and end of the same pathway, then we would expect phenotypic differences to be due to differences in the pathway length of their respective networks. Alternatively, if each pathway has its own control mechanism, then phenotypic differences would be the result of differences in the connection density of pathways present in each network. It is also possible that regulatory mechanisms are independent of the network structure, and if this is the case phenotypic differences would not be related to structural properties of the network. To test these hypotheses we extracted carotenoid compounds from the feathers of 59 female house finches (Haemorhous mexicanus) from Arizona and Montana and constructed carotenoid metabolic networks for each individual. We examined whether the highly variable expression of carotenoids in female feathers is caused by differences in the expression of carotenoids as the result of the gain or loss of compounds within the same pathway or among distinct pathways. We find that most of the differences between individuals were caused by differences in which pathways were expressed and not by differences in the elongation of the same pathway. These findings enhance our understanding of biochemical mechanisms that underlie avian carotenoid coloration diversification.
Type:
text; Electronic Thesis
Degree Name:
B.S.
Degree Level:
Bachelors
Degree Program:
Honors College; Ecology and Evolutionary Biology
Degree Grantor:
University of Arizona
Advisor:
Badyaev, Alexander V.

Full metadata record

DC FieldValue Language
dc.language.isoen_USen
dc.titleCORRESPONDENCE BETWEEN STRUCTURAL AND DYNAMIC PROPERTIES IN A BIOCHEMICAL NETWORKen_US
dc.creatorANDREWS, JOHN EMMETen
dc.contributor.authorANDREWS, JOHN EMMETen
dc.date.issued2016-
dc.publisherThe University of Arizona.en
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en
dc.description.abstractPhenotypic traits are determined by networks of interactions between genes, proteins and enzymes. Structural positions of regulatory mechanisms in the network can determine variability in its elements. Here we examine the topological properties of controls that regulate element expression in a network. If distinct regulatory controls are located at the beginning and end of the same pathway, then we would expect phenotypic differences to be due to differences in the pathway length of their respective networks. Alternatively, if each pathway has its own control mechanism, then phenotypic differences would be the result of differences in the connection density of pathways present in each network. It is also possible that regulatory mechanisms are independent of the network structure, and if this is the case phenotypic differences would not be related to structural properties of the network. To test these hypotheses we extracted carotenoid compounds from the feathers of 59 female house finches (Haemorhous mexicanus) from Arizona and Montana and constructed carotenoid metabolic networks for each individual. We examined whether the highly variable expression of carotenoids in female feathers is caused by differences in the expression of carotenoids as the result of the gain or loss of compounds within the same pathway or among distinct pathways. We find that most of the differences between individuals were caused by differences in which pathways were expressed and not by differences in the elongation of the same pathway. These findings enhance our understanding of biochemical mechanisms that underlie avian carotenoid coloration diversification.en
dc.typetexten
dc.typeElectronic Thesisen
thesis.degree.nameB.S.en
thesis.degree.levelBachelorsen
thesis.degree.disciplineHonors Collegeen
thesis.degree.disciplineEcology and Evolutionary Biologyen
thesis.degree.grantorUniversity of Arizonaen
dc.contributor.advisorBadyaev, Alexander V.en
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