EXAMINING THE ROLE OF THE PRELIMIC PREFRONTAL (PrLPFC) CORTEX IN CHRONIC PAIN

Persistent Link:
http://hdl.handle.net/10150/612465
Title:
EXAMINING THE ROLE OF THE PRELIMIC PREFRONTAL (PrLPFC) CORTEX IN CHRONIC PAIN
Author:
AMELI, NINA
Issue Date:
2016
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Chronic pain, especially neuropathic pain, is always a topic of discussion and a huge issue in the United States affecting millions that seek pharmacological options for treatment. Opioids are the number one prescribed medication for treating chronic pain, but have been linked to addiction. The full pain circuit has not yet been mapped with respect to chronic pain, which contribute to the continuous research and exploration of it. Several regions of the brain are hyperexcitable during a painful stimulus including the prelimbic prefrontal cortex (PrLPFC) which is the focus of this study. This region of the brain has not been targeted for treatment yet but findings suggest it has a strong correlation that should be further explored. Our study confirmed increased activity of the PrLPRC neurons after injury and increased pain tolerance with use of Retigabine (potassium channel opener), baclofen (GabaA agonist) and muscimol (GabaB agonist).
Type:
text; Electronic Thesis
Degree Name:
B.S.
Degree Level:
Bachelors
Degree Program:
Honors College; Physiology
Degree Grantor:
University of Arizona
Advisor:
Largent-Milnes, Tally

Full metadata record

DC FieldValue Language
dc.language.isoen_USen
dc.titleEXAMINING THE ROLE OF THE PRELIMIC PREFRONTAL (PrLPFC) CORTEX IN CHRONIC PAINen_US
dc.creatorAMELI, NINAen
dc.contributor.authorAMELI, NINAen
dc.date.issued2016-
dc.publisherThe University of Arizona.en
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en
dc.description.abstractChronic pain, especially neuropathic pain, is always a topic of discussion and a huge issue in the United States affecting millions that seek pharmacological options for treatment. Opioids are the number one prescribed medication for treating chronic pain, but have been linked to addiction. The full pain circuit has not yet been mapped with respect to chronic pain, which contribute to the continuous research and exploration of it. Several regions of the brain are hyperexcitable during a painful stimulus including the prelimbic prefrontal cortex (PrLPFC) which is the focus of this study. This region of the brain has not been targeted for treatment yet but findings suggest it has a strong correlation that should be further explored. Our study confirmed increased activity of the PrLPRC neurons after injury and increased pain tolerance with use of Retigabine (potassium channel opener), baclofen (GabaA agonist) and muscimol (GabaB agonist).en
dc.typetexten
dc.typeElectronic Thesisen
thesis.degree.nameB.S.en
thesis.degree.levelBachelorsen
thesis.degree.disciplineHonors Collegeen
thesis.degree.disciplinePhysiologyen
thesis.degree.grantorUniversity of Arizonaen
dc.contributor.advisorLargent-Milnes, Tallyen
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