Most of the extant mtDNA boundaries in South and Southwest Asia were likely shaped during the initial settlement of Eurasia by anatomically modern humans

Persistent Link:
http://hdl.handle.net/10150/610388
Title:
Most of the extant mtDNA boundaries in South and Southwest Asia were likely shaped during the initial settlement of Eurasia by anatomically modern humans
Author:
Metspalu, Mait; Kivisild, Toomas; Metspalu, Ene; Parik, Juri; Hudjashov, Georgi; Kaldma, Katrin; Serk, Piia; Karmin, Monika; Behar, Doron; Gilbert, M. T.; Endicott, Phillip; Mastana, Sarabjit; Papiha, Surinder; Skorecki, Karl; Torroni, Antonio; Villems, Richard
Affiliation:
Institute of Molecular and Cell Biology, Tartu University, Tartu, Estonia; Bruce Rappaport Faculty of Medicine and Research Institute, Technion and Rambam Medical Center, Haifa, Israel; Dipartimento di Genetica e Microbiologia, Università di Pavia, Pavia, Italy; Department of Human Sciences, Loughborough University, Loughborough, United Kingdom; Department of Human Genetics, University of Newcastle-upon-Tyne, United Kingdom; Ecology and Evolutionary Biology, The University of Arizona, Tucson, Arizona, USA; Henry Wellcome Ancient Biomolecules Centre, Department of Zoology, University of Oxford, Oxford OX1 3PS,United Kingdom
Issue Date:
2004
Publisher:
BioMed Central
Citation:
BMC Genetics 2004, 5:26 doi:10.1186/1471-2156-5-26
Journal:
BMC Genetics
Rights:
© 2004 Metspalu et al; licensee BioMed Central Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0)
Collection Information:
This item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.
Abstract:
BACKGROUND:Recent advances in the understanding of the maternal and paternal heritage of south and southwest Asian populations have highlighted their role in the colonization of Eurasia by anatomically modern humans. Further understanding requires a deeper insight into the topology of the branches of the Indian mtDNA phylogenetic tree, which should be contextualized within the phylogeography of the neighboring regional mtDNA variation. Accordingly, we have analyzed mtDNA control and coding region variation in 796 Indian (including both tribal and caste populations from different parts of India) and 436 Iranian mtDNAs. The results were integrated and analyzed together with published data from South, Southeast Asia and West Eurasia.RESULTS:Four new Indian-specific haplogroup M sub-clades were defined. These, in combination with two previously described haplogroups, encompass approximately one third of the haplogroup M mtDNAs in India. Their phylogeography and spread among different linguistic phyla and social strata was investigated in detail. Furthermore, the analysis of the Iranian mtDNA pool revealed patterns of limited reciprocal gene flow between Iran and the Indian sub-continent and allowed the identification of different assemblies of shared mtDNA sub-clades.CONCLUSIONS:Since the initial peopling of South and West Asia by anatomically modern humans, when this region may well have provided the initial settlers who colonized much of the rest of Eurasia, the gene flow in and out of India of the maternally transmitted mtDNA has been surprisingly limited. Specifically, our analysis of the mtDNA haplogroups, which are shared between Indian and Iranian populations and exhibit coalescence ages corresponding to around the early Upper Paleolithic, indicates that they are present in India largely as Indian-specific sub-lineages. In contrast, other ancient Indian-specific variants of M and R are very rare outside the sub-continent.
EISSN:
1471-2156
DOI:
10.1186/1471-2156-5-26
Version:
Final published version
Additional Links:
http://www.biomedcentral.com/1471-2156/5/26

Full metadata record

DC FieldValue Language
dc.contributor.authorMetspalu, Maiten
dc.contributor.authorKivisild, Toomasen
dc.contributor.authorMetspalu, Eneen
dc.contributor.authorParik, Jurien
dc.contributor.authorHudjashov, Georgien
dc.contributor.authorKaldma, Katrinen
dc.contributor.authorSerk, Piiaen
dc.contributor.authorKarmin, Monikaen
dc.contributor.authorBehar, Doronen
dc.contributor.authorGilbert, M. T.en
dc.contributor.authorEndicott, Phillipen
dc.contributor.authorMastana, Sarabjiten
dc.contributor.authorPapiha, Surinderen
dc.contributor.authorSkorecki, Karlen
dc.contributor.authorTorroni, Antonioen
dc.contributor.authorVillems, Richarden
dc.date.accessioned2016-05-20T09:05:41Z-
dc.date.available2016-05-20T09:05:41Z-
dc.date.issued2004en
dc.identifier.citationBMC Genetics 2004, 5:26 doi:10.1186/1471-2156-5-26en
dc.identifier.doi10.1186/1471-2156-5-26en
dc.identifier.urihttp://hdl.handle.net/10150/610388-
dc.description.abstractBACKGROUND:Recent advances in the understanding of the maternal and paternal heritage of south and southwest Asian populations have highlighted their role in the colonization of Eurasia by anatomically modern humans. Further understanding requires a deeper insight into the topology of the branches of the Indian mtDNA phylogenetic tree, which should be contextualized within the phylogeography of the neighboring regional mtDNA variation. Accordingly, we have analyzed mtDNA control and coding region variation in 796 Indian (including both tribal and caste populations from different parts of India) and 436 Iranian mtDNAs. The results were integrated and analyzed together with published data from South, Southeast Asia and West Eurasia.RESULTS:Four new Indian-specific haplogroup M sub-clades were defined. These, in combination with two previously described haplogroups, encompass approximately one third of the haplogroup M mtDNAs in India. Their phylogeography and spread among different linguistic phyla and social strata was investigated in detail. Furthermore, the analysis of the Iranian mtDNA pool revealed patterns of limited reciprocal gene flow between Iran and the Indian sub-continent and allowed the identification of different assemblies of shared mtDNA sub-clades.CONCLUSIONS:Since the initial peopling of South and West Asia by anatomically modern humans, when this region may well have provided the initial settlers who colonized much of the rest of Eurasia, the gene flow in and out of India of the maternally transmitted mtDNA has been surprisingly limited. Specifically, our analysis of the mtDNA haplogroups, which are shared between Indian and Iranian populations and exhibit coalescence ages corresponding to around the early Upper Paleolithic, indicates that they are present in India largely as Indian-specific sub-lineages. In contrast, other ancient Indian-specific variants of M and R are very rare outside the sub-continent.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urlhttp://www.biomedcentral.com/1471-2156/5/26en
dc.rights© 2004 Metspalu et al; licensee BioMed Central Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0)en
dc.titleMost of the extant mtDNA boundaries in South and Southwest Asia were likely shaped during the initial settlement of Eurasia by anatomically modern humansen
dc.typeArticleen
dc.identifier.eissn1471-2156en
dc.contributor.departmentInstitute of Molecular and Cell Biology, Tartu University, Tartu, Estoniaen
dc.contributor.departmentBruce Rappaport Faculty of Medicine and Research Institute, Technion and Rambam Medical Center, Haifa, Israelen
dc.contributor.departmentDipartimento di Genetica e Microbiologia, Università di Pavia, Pavia, Italyen
dc.contributor.departmentDepartment of Human Sciences, Loughborough University, Loughborough, United Kingdomen
dc.contributor.departmentDepartment of Human Genetics, University of Newcastle-upon-Tyne, United Kingdomen
dc.contributor.departmentEcology and Evolutionary Biology, The University of Arizona, Tucson, Arizona, USAen
dc.contributor.departmentHenry Wellcome Ancient Biomolecules Centre, Department of Zoology, University of Oxford, Oxford OX1 3PS,United Kingdomen
dc.identifier.journalBMC Geneticsen
dc.description.collectioninformationThis item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen
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