Heat shock protein 60 reactive T cells in juvenile idiopathic arthritis: what is new?

Persistent Link:
http://hdl.handle.net/10150/610370
Title:
Heat shock protein 60 reactive T cells in juvenile idiopathic arthritis: what is new?
Author:
Vercoulen, Yvonne; van Teijlingen, Nienke; de Kleer, Isme; Kamphuis, Sylvia; Albani, Salvatore; Prakken, Berent
Affiliation:
Department of Pediatric Immunology, Wilhelmina Children's hospital, UMCU, Lundlaan 6, 3584 EA, Utrecht, The Netherlands; Eureka Institute for Translational Medicine, Viale Teracati 50a, 96100, Siracusa, Italy; The University of Arizona College of Medicine, 1501 N. Campbell Avenue, PO BOX 245093, Tucson, AZ, USA
Issue Date:
2009
Publisher:
BioMed Central
Citation:
Arthritis Research & Therapy 2009, 11:231 (doi:10.1186/ar2674)
Journal:
Arthritis Research & Therapy
Rights:
© 2009 BioMed Central Ltd
Collection Information:
This item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.
Abstract:
Juvenile idiopathic arthritis (JIA) is a disease characterized by chronic joint inflammation, caused by a deregulated immune response. In patients with JIA, heat shock proteins (HSPs) are highly expressed in the synovial lining tissues of inflamed joints. HSPs are endogenous proteins that are expressed upon cellular stress and are able to modulate immune responses. In this review, we concentrate on the role of HSPs, especially HSP60, in modulating immune responses in both experimental and human arthritis, with a focus on JIA. We will mainly discuss the tolerogenic immune responses induced by HSPs, which could have a beneficial effect in JIA. Overall, we will discuss the immune modulatory capacity of HSPs, and the underlying mechanisms of HSP60-mediated immune regulation in JIA, and how this can be translated into therapy.
EISSN:
1478-6362
DOI:
10.1186/ar2674
Version:
Final published version
Additional Links:
http://arthritis-research.com/content/11/3/231

Full metadata record

DC FieldValue Language
dc.contributor.authorVercoulen, Yvonneen
dc.contributor.authorvan Teijlingen, Nienkeen
dc.contributor.authorde Kleer, Ismeen
dc.contributor.authorKamphuis, Sylviaen
dc.contributor.authorAlbani, Salvatoreen
dc.contributor.authorPrakken, Berenten
dc.date.accessioned2016-05-20T09:05:19Z-
dc.date.available2016-05-20T09:05:19Z-
dc.date.issued2009en
dc.identifier.citationArthritis Research & Therapy 2009, 11:231 (doi:10.1186/ar2674)en
dc.identifier.doi10.1186/ar2674en
dc.identifier.urihttp://hdl.handle.net/10150/610370-
dc.description.abstractJuvenile idiopathic arthritis (JIA) is a disease characterized by chronic joint inflammation, caused by a deregulated immune response. In patients with JIA, heat shock proteins (HSPs) are highly expressed in the synovial lining tissues of inflamed joints. HSPs are endogenous proteins that are expressed upon cellular stress and are able to modulate immune responses. In this review, we concentrate on the role of HSPs, especially HSP60, in modulating immune responses in both experimental and human arthritis, with a focus on JIA. We will mainly discuss the tolerogenic immune responses induced by HSPs, which could have a beneficial effect in JIA. Overall, we will discuss the immune modulatory capacity of HSPs, and the underlying mechanisms of HSP60-mediated immune regulation in JIA, and how this can be translated into therapy.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urlhttp://arthritis-research.com/content/11/3/231en
dc.rights© 2009 BioMed Central Ltden
dc.titleHeat shock protein 60 reactive T cells in juvenile idiopathic arthritis: what is new?en
dc.typeArticleen
dc.identifier.eissn1478-6362en
dc.contributor.departmentDepartment of Pediatric Immunology, Wilhelmina Children's hospital, UMCU, Lundlaan 6, 3584 EA, Utrecht, The Netherlandsen
dc.contributor.departmentEureka Institute for Translational Medicine, Viale Teracati 50a, 96100, Siracusa, Italyen
dc.contributor.departmentThe University of Arizona College of Medicine, 1501 N. Campbell Avenue, PO BOX 245093, Tucson, AZ, USAen
dc.identifier.journalArthritis Research & Therapyen
dc.description.collectioninformationThis item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen
All Items in UA Campus Repository are protected by copyright, with all rights reserved, unless otherwise indicated.