A model for homeopathic remedy effects: low dose nanoparticles, allostatic cross-adaptation, and time-dependent sensitization in a complex adaptive system

Persistent Link:
http://hdl.handle.net/10150/610361
Title:
A model for homeopathic remedy effects: low dose nanoparticles, allostatic cross-adaptation, and time-dependent sensitization in a complex adaptive system
Author:
Bell, Iris; Koithan, Mary
Affiliation:
Department of Family and Community Medicine, University of Arizona College of Medicine, 1450 N Cherry, MS 245052, Tucson, AZ, 85719, USA; University of Arizona College of Nursing, Tucson, AZ, USA
Issue Date:
2012
Publisher:
BioMed Central
Citation:
Bell and Koithan BMC Complementary and Alternative Medicine 2012, 12:191 http://www.biomedcentral.com/1472-6882/12/191
Journal:
BMC Complementary and Alternative Medicine
Rights:
© 2012 Bell and Koithan; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0
Collection Information:
This item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.
Abstract:
BACKGROUND:This paper proposes a novel model for homeopathic remedy action on living systems. Research indicates that homeopathic remedies (a) contain measurable source and silica nanoparticles heterogeneously dispersed in colloidal solution; (b) act by modulating biological function of the allostatic stress response network (c) evoke biphasic actions on living systems via organism-dependent adaptive and endogenously amplified effects; (d) improve systemic resilience.DISCUSSION:The proposed active components of homeopathic remedies are nanoparticles of source substance in water-based colloidal solution, not bulk-form drugs. Nanoparticles have unique biological and physico-chemical properties, including increased catalytic reactivity, protein and DNA adsorption, bioavailability, dose-sparing, electromagnetic, and quantum effects different from bulk-form materials. Trituration and/or liquid succussions during classical remedy preparation create "top-down" nanostructures. Plants can biosynthesize remedy-templated silica nanostructures. Nanoparticles stimulate hormesis, a beneficial low-dose adaptive response. Homeopathic remedies prescribed in low doses spaced intermittently over time act as biological signals that stimulate the organism's allostatic biological stress response network, evoking nonlinear modulatory, self-organizing change. Potential mechanisms include time-dependent sensitization (TDS), a type of adaptive plasticity/metaplasticity involving progressive amplification of host responses, which reverse direction and oscillate at physiological limits. To mobilize hormesis and TDS, the remedy must be appraised as a salient, but low level, novel threat, stressor, or homeostatic disruption for the whole organism. Silica nanoparticles adsorb remedy source and amplify effects. Properly-timed remedy dosing elicits disease-primed compensatory reversal in direction of maladaptive dynamics of the allostatic network, thus promoting resilience and recovery from disease.SUMMARY:Homeopathic remedies are proposed as source nanoparticles that mobilize hormesis and time-dependent sensitization via non-pharmacological effects on specific biological adaptive and amplification mechanisms. The nanoparticle nature of remedies would distinguish them from conventional bulk drugs in structure, morphology, and functional properties. Outcomes would depend upon the ability of the organism to respond to the remedy as a novel stressor or heterotypic biological threat, initiating reversals of cumulative, cross-adapted biological maladaptations underlying disease in the allostatic stress response network. Systemic resilience would improve. This model provides a foundation for theory-driven research on the role of nanomaterials in living systems, mechanisms of homeopathic remedy actions and translational uses in nanomedicine.
EISSN:
1472-6882
DOI:
10.1186/1472-6882-12-191
Keywords:
Homeopathy; Nanoparticles; Silica; Epitaxy; Hormesis; Cross adaptation; Time dependent sensitization; Metaplasticity; Allostasis; Complex adaptive system; Stress response network; Resilience; Nanomedicine
Version:
Final published version
Additional Links:
http://www.biomedcentral.com/1472-6882/12/191

Full metadata record

DC FieldValue Language
dc.contributor.authorBell, Irisen
dc.contributor.authorKoithan, Maryen
dc.date.accessioned2016-05-20T09:05:07Z-
dc.date.available2016-05-20T09:05:07Z-
dc.date.issued2012en
dc.identifier.citationBell and Koithan BMC Complementary and Alternative Medicine 2012, 12:191 http://www.biomedcentral.com/1472-6882/12/191en
dc.identifier.doi10.1186/1472-6882-12-191en
dc.identifier.urihttp://hdl.handle.net/10150/610361-
dc.description.abstractBACKGROUND:This paper proposes a novel model for homeopathic remedy action on living systems. Research indicates that homeopathic remedies (a) contain measurable source and silica nanoparticles heterogeneously dispersed in colloidal solutionen
dc.description.abstract(b) act by modulating biological function of the allostatic stress response network (c) evoke biphasic actions on living systems via organism-dependent adaptive and endogenously amplified effectsen
dc.description.abstract(d) improve systemic resilience.DISCUSSION:The proposed active components of homeopathic remedies are nanoparticles of source substance in water-based colloidal solution, not bulk-form drugs. Nanoparticles have unique biological and physico-chemical properties, including increased catalytic reactivity, protein and DNA adsorption, bioavailability, dose-sparing, electromagnetic, and quantum effects different from bulk-form materials. Trituration and/or liquid succussions during classical remedy preparation create "top-down" nanostructures. Plants can biosynthesize remedy-templated silica nanostructures. Nanoparticles stimulate hormesis, a beneficial low-dose adaptive response. Homeopathic remedies prescribed in low doses spaced intermittently over time act as biological signals that stimulate the organism's allostatic biological stress response network, evoking nonlinear modulatory, self-organizing change. Potential mechanisms include time-dependent sensitization (TDS), a type of adaptive plasticity/metaplasticity involving progressive amplification of host responses, which reverse direction and oscillate at physiological limits. To mobilize hormesis and TDS, the remedy must be appraised as a salient, but low level, novel threat, stressor, or homeostatic disruption for the whole organism. Silica nanoparticles adsorb remedy source and amplify effects. Properly-timed remedy dosing elicits disease-primed compensatory reversal in direction of maladaptive dynamics of the allostatic network, thus promoting resilience and recovery from disease.SUMMARY:Homeopathic remedies are proposed as source nanoparticles that mobilize hormesis and time-dependent sensitization via non-pharmacological effects on specific biological adaptive and amplification mechanisms. The nanoparticle nature of remedies would distinguish them from conventional bulk drugs in structure, morphology, and functional properties. Outcomes would depend upon the ability of the organism to respond to the remedy as a novel stressor or heterotypic biological threat, initiating reversals of cumulative, cross-adapted biological maladaptations underlying disease in the allostatic stress response network. Systemic resilience would improve. This model provides a foundation for theory-driven research on the role of nanomaterials in living systems, mechanisms of homeopathic remedy actions and translational uses in nanomedicine.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urlhttp://www.biomedcentral.com/1472-6882/12/191en
dc.rights© 2012 Bell and Koithan; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0en
dc.subjectHomeopathyen
dc.subjectNanoparticlesen
dc.subjectSilicaen
dc.subjectEpitaxyen
dc.subjectHormesisen
dc.subjectCross adaptationen
dc.subjectTime dependent sensitizationen
dc.subjectMetaplasticityen
dc.subjectAllostasisen
dc.subjectComplex adaptive systemen
dc.subjectStress response networken
dc.subjectResilienceen
dc.subjectNanomedicineen
dc.titleA model for homeopathic remedy effects: low dose nanoparticles, allostatic cross-adaptation, and time-dependent sensitization in a complex adaptive systemen
dc.typeArticleen
dc.identifier.eissn1472-6882en
dc.contributor.departmentDepartment of Family and Community Medicine, University of Arizona College of Medicine, 1450 N Cherry, MS 245052, Tucson, AZ, 85719, USAen
dc.contributor.departmentUniversity of Arizona College of Nursing, Tucson, AZ, USAen
dc.identifier.journalBMC Complementary and Alternative Medicineen
dc.description.collectioninformationThis item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen
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