Continued breathing followed by gasping or apnea in a swine model of ventricular fibrillation cardiac arrest

Persistent Link:
http://hdl.handle.net/10150/610352
Title:
Continued breathing followed by gasping or apnea in a swine model of ventricular fibrillation cardiac arrest
Author:
Zuercher, Mathias; Ewy, Gordon; Hilwig, Ronald; Sanders, Arthur; Otto, Charles; Berg, Robert; Kern, Karl
Affiliation:
University of Arizona Sarver Heart Center, Tucson, AZ, USA; Department of Anesthesia and Intensive Care Medicine, University Hospital Basel, Basel, Switzerland; Department of Medicine, University of Arizona College of Medicine, Tucson, AZ, USA; Department of Emergency Medicine, University of Arizona College of Medicine, Tucson, AZ, USA; Department of Anesthesiology, University of Arizona College of Medicine, Tucson, AZ, USA; Department of Anesthesia and Critical Care, The Children's Hospital of Philadelphia, Philadelphia, PA, USA
Issue Date:
2010
Publisher:
BioMed Central
Citation:
Zuercher et al. BMC Cardiovascular Disorders 2010, 10:36 http://www.biomedcentral.com/1471-2261/10/36
Journal:
BMC Cardiovascular Disorders
Rights:
© 2010 Zuercher et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0)
Collection Information:
This item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.
Abstract:
BACKGROUND:Continued breathing following ventricular fibrillation has here-to-fore not been described.METHODS:We analyzed the spontaneous ventilatory activity during the first several minutes of ventricular fibrillation (VF) in our isoflurane anesthesized swine model of out-of-hospital cardiac arrest. The frequency and type of ventilatory activity was monitored by pneumotachometer and main stream infrared capnometer and analyzed in 61 swine during the first 3 to 6 minutes of untreated VF.RESULTS:During the first minute of VF, the air flow pattern in all 61 swine was similar to those recorded during regular spontaneous breathing during anesthesia and was clearly different from the patterns of gasping. The average rate of continued breathing during the first minute of untreated VF was 10 breaths per minute. During the second minute of untreated VF, spontaneous breathing activity either stopped or became typical of gasping. During minutes 2 to 5 of untreated VF, most animals exhibited very slow spontaneous ventilatory activity with a pattern typical of gasping; and the pattern of gasping was crescendo-decrescendo, as has been previously reported. In the absence of therapy, all ventilatory activity stopped 6 minutes after VF cardiac arrest.CONCLUSION:In our swine model of VF cardiac arrest, we documented that normal breathing continued for the first minute following cardiac arrest.
EISSN:
1471-2261
DOI:
10.1186/1471-2261-10-36
Version:
Final published version
Additional Links:
http://www.biomedcentral.com/1471-2261/10/36

Full metadata record

DC FieldValue Language
dc.contributor.authorZuercher, Mathiasen
dc.contributor.authorEwy, Gordonen
dc.contributor.authorHilwig, Ronalden
dc.contributor.authorSanders, Arthuren
dc.contributor.authorOtto, Charlesen
dc.contributor.authorBerg, Roberten
dc.contributor.authorKern, Karlen
dc.date.accessioned2016-05-20T09:04:55Z-
dc.date.available2016-05-20T09:04:55Z-
dc.date.issued2010en
dc.identifier.citationZuercher et al. BMC Cardiovascular Disorders 2010, 10:36 http://www.biomedcentral.com/1471-2261/10/36en
dc.identifier.doi10.1186/1471-2261-10-36en
dc.identifier.urihttp://hdl.handle.net/10150/610352-
dc.description.abstractBACKGROUND:Continued breathing following ventricular fibrillation has here-to-fore not been described.METHODS:We analyzed the spontaneous ventilatory activity during the first several minutes of ventricular fibrillation (VF) in our isoflurane anesthesized swine model of out-of-hospital cardiac arrest. The frequency and type of ventilatory activity was monitored by pneumotachometer and main stream infrared capnometer and analyzed in 61 swine during the first 3 to 6 minutes of untreated VF.RESULTS:During the first minute of VF, the air flow pattern in all 61 swine was similar to those recorded during regular spontaneous breathing during anesthesia and was clearly different from the patterns of gasping. The average rate of continued breathing during the first minute of untreated VF was 10 breaths per minute. During the second minute of untreated VF, spontaneous breathing activity either stopped or became typical of gasping. During minutes 2 to 5 of untreated VF, most animals exhibited very slow spontaneous ventilatory activity with a pattern typical of gaspingen
dc.description.abstractand the pattern of gasping was crescendo-decrescendo, as has been previously reported. In the absence of therapy, all ventilatory activity stopped 6 minutes after VF cardiac arrest.CONCLUSION:In our swine model of VF cardiac arrest, we documented that normal breathing continued for the first minute following cardiac arrest.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urlhttp://www.biomedcentral.com/1471-2261/10/36en
dc.rights© 2010 Zuercher et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0)en
dc.titleContinued breathing followed by gasping or apnea in a swine model of ventricular fibrillation cardiac arresten
dc.typeArticleen
dc.identifier.eissn1471-2261en
dc.contributor.departmentUniversity of Arizona Sarver Heart Center, Tucson, AZ, USAen
dc.contributor.departmentDepartment of Anesthesia and Intensive Care Medicine, University Hospital Basel, Basel, Switzerlanden
dc.contributor.departmentDepartment of Medicine, University of Arizona College of Medicine, Tucson, AZ, USAen
dc.contributor.departmentDepartment of Emergency Medicine, University of Arizona College of Medicine, Tucson, AZ, USAen
dc.contributor.departmentDepartment of Anesthesiology, University of Arizona College of Medicine, Tucson, AZ, USAen
dc.contributor.departmentDepartment of Anesthesia and Critical Care, The Children's Hospital of Philadelphia, Philadelphia, PA, USAen
dc.identifier.journalBMC Cardiovascular Disordersen
dc.description.collectioninformationThis item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen
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