Predictors of recurrence free survival for patients with stage II and III colon cancer

Persistent Link:
http://hdl.handle.net/10150/610351
Title:
Predictors of recurrence free survival for patients with stage II and III colon cancer
Author:
Tsikitis, Vassiliki; Larson, David; Huebner, Marianne; Lohse, Christine; Thompson, Patricia
Affiliation:
Department of Surgery, Oregon Health & Science University, Portland, Oregon, USA; Department of Surgery, The Mayo Clinic, Rochester, Minnesota, 200 First Street SW, 55905 Rochester, MN, USA; Department of Health Sciences Research, The Mayo Clinic, Rochester, Minnesota, 200 First Street SW, 55905 Rochester, MN, USA; Department of Cellular and Molecular Medicine, University of Arizona, Tucson, Arizona, 1333 N. Martin Avenue, 85721 Tucson, Arizona, USA
Issue Date:
2014
Publisher:
BioMed Central
Citation:
Tsikitis et al. BMC Cancer 2014, 14:336 http://www.biomedcentral.com/1471-2407/14/336
Journal:
BMC Cancer
Rights:
© 2014 Tsikitis et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0)
Collection Information:
This item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.
Abstract:
BACKGROUND:The aim of this study was to evaluate clinico-pathologic specific predictors of recurrence for stage II/III disease. Improving recurrence prediction for resected stage II/III colon cancer patients could alter surveillance strategies, providing opportunities for more informed use of chemotherapy for high risk individuals.METHODS:871 stage II and 265 stage III patients with colon cancers were included. Features studied included surgery date, age, gender, chemotherapy, tumor location, number of positive lymph nodes, tumor differentiation, and lymphovascular and perineural invasion. Time to recurrence was evaluated, using Cox's proportional hazards models. The predictive ability of the multivariable models was evaluated using the concordance (c) index.RESULTS:For stage II cancer patients, estimated recurrence-free survival rates at one, three, five, and seven years following surgery were 98%, 92%, 90%, and 89%. Only T stage was significantly associated with recurrence. Estimated recurrence-free survival rates for stage III patients at one, three, five, and seven years following surgery were 94%, 78%, 70%, and 66%. Higher recurrence rates were seen in patients who didn't receive chemotherapy (p=0.023), with a higher number of positive nodes (p<0.001). The c-index for the stage II model was 0.55 and 0.68 for stage III.CONCLUSIONS:Current clinic-pathologic information is inadequate for prediction of colon cancer recurrence after resection for stage II and IIII patients. Identification and clinical use of molecular markers to identify the earlier stage II and III colon cancer patients at elevated risk of recurrence are needed to improve prognostication of early stage colon cancers.
EISSN:
 1471-2407
DOI:
10.1186/1471-2407-14-336
Keywords:
Chemotherapy; Disease-free survival; Early stage colon cancer; Clinico-pathologic; Predictors of recurrence
Version:
Final published version
Additional Links:
http://www.biomedcentral.com/1471-2407/14/336

Full metadata record

DC FieldValue Language
dc.contributor.authorTsikitis, Vassilikien
dc.contributor.authorLarson, Daviden
dc.contributor.authorHuebner, Marianneen
dc.contributor.authorLohse, Christineen
dc.contributor.authorThompson, Patriciaen
dc.date.accessioned2016-05-20T09:04:53Z-
dc.date.available2016-05-20T09:04:53Z-
dc.date.issued2014en
dc.identifier.citationTsikitis et al. BMC Cancer 2014, 14:336 http://www.biomedcentral.com/1471-2407/14/336en
dc.identifier.doi10.1186/1471-2407-14-336en
dc.identifier.urihttp://hdl.handle.net/10150/610351-
dc.description.abstractBACKGROUND:The aim of this study was to evaluate clinico-pathologic specific predictors of recurrence for stage II/III disease. Improving recurrence prediction for resected stage II/III colon cancer patients could alter surveillance strategies, providing opportunities for more informed use of chemotherapy for high risk individuals.METHODS:871 stage II and 265 stage III patients with colon cancers were included. Features studied included surgery date, age, gender, chemotherapy, tumor location, number of positive lymph nodes, tumor differentiation, and lymphovascular and perineural invasion. Time to recurrence was evaluated, using Cox's proportional hazards models. The predictive ability of the multivariable models was evaluated using the concordance (c) index.RESULTS:For stage II cancer patients, estimated recurrence-free survival rates at one, three, five, and seven years following surgery were 98%, 92%, 90%, and 89%. Only T stage was significantly associated with recurrence. Estimated recurrence-free survival rates for stage III patients at one, three, five, and seven years following surgery were 94%, 78%, 70%, and 66%. Higher recurrence rates were seen in patients who didn't receive chemotherapy (p=0.023), with a higher number of positive nodes (p<0.001). The c-index for the stage II model was 0.55 and 0.68 for stage III.CONCLUSIONS:Current clinic-pathologic information is inadequate for prediction of colon cancer recurrence after resection for stage II and IIII patients. Identification and clinical use of molecular markers to identify the earlier stage II and III colon cancer patients at elevated risk of recurrence are needed to improve prognostication of early stage colon cancers.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urlhttp://www.biomedcentral.com/1471-2407/14/336en
dc.rights© 2014 Tsikitis et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0)en
dc.subjectChemotherapyen
dc.subjectDisease-free survivalen
dc.subjectEarly stage colon canceren
dc.subjectClinico-pathologicen
dc.subjectPredictors of recurrenceen
dc.titlePredictors of recurrence free survival for patients with stage II and III colon canceren
dc.typeArticleen
dc.identifier.eissn 1471-2407en
dc.contributor.departmentDepartment of Surgery, Oregon Health & Science University, Portland, Oregon, USAen
dc.contributor.departmentDepartment of Surgery, The Mayo Clinic, Rochester, Minnesota, 200 First Street SW, 55905 Rochester, MN, USAen
dc.contributor.departmentDepartment of Health Sciences Research, The Mayo Clinic, Rochester, Minnesota, 200 First Street SW, 55905 Rochester, MN, USAen
dc.contributor.departmentDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson, Arizona, 1333 N. Martin Avenue, 85721 Tucson, Arizona, USAen
dc.identifier.journalBMC Canceren
dc.description.collectioninformationThis item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen
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