Feasibility of intensity-modulated and image-guided radiotherapy for locally advanced esophageal cancer

Persistent Link:
http://hdl.handle.net/10150/610350
Title:
Feasibility of intensity-modulated and image-guided radiotherapy for locally advanced esophageal cancer
Author:
Nguyen, Nam; Jang, Siyoung; Vock, Jacqueline; Vinh-Hung, Vincent; Chi, Alexander; Vos, Paul; Pugh, Judith; Vo, Richard; Ceizyk, Misty; Desai, Anand; Smith-Raymond, Lexie; the International Geriatric, Radiotherapy Group
Affiliation:
Department of Radiation Oncology, Howard University Hospital, 2401 Georgia Avenue, N.W., Room 2055, Washington, DC 20060, USA; Department of Radiation Oncology, Lindenhofspital, Bern, Switzerland; Department of Radiation Oncology, University Hospitals of Geneva, Geneva, Switzerland; Department of Radiation Oncology, University of West Virginia, Morgantown, WV, USA; Department of Biostatistics, East Carolina University, Greenville, NC, USA; Department of Pathology, University of Arizona, Tucson, AZ, USA; Department of Pediatry, University of Virginia, Charlottesville, VA, USA; Department of Radiation Oncology, Akron City Hospital, Akron, OH, USA; Department of Radiation Oncology, University of Arizona, Tucson, AZ, USA
Issue Date:
2014
Publisher:
BioMed Central
Citation:
Nguyen et al. BMC Cancer 2014, 14:265 http://www.biomedcentral.com/1471-2407/14/265
Journal:
BMC Cancer
Rights:
© 2014 Nguyen et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0)
Collection Information:
This item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.
Abstract:
BACKGROUND:In this study the feasibility of intensity-modulated radiotherapy (IMRT) and tomotherapy-based image-guided radiotherapy (IGRT) for locally advanced esophageal cancer was assessed.METHODS:A retrospective study of ten patients with locally advanced esophageal cancer who underwent concurrent chemotherapy with IMRT (1) and IGRT (9) was conducted. The gross tumor volume was treated to a median dose of 70Gy (62.4-75Gy).RESULTS:At a median follow-up of 14months (1-39 months), three patients developed local failures, six patients developed distant metastases, and complications occurred in two patients (1 tracheoesophageal fistula, 1 esophageal stricture requiring repeated dilatations). No patients developed grade 3-4 pneumonitis or cardiac complications.CONCLUSIONS:IMRT and IGRT may be effective for the treatment of locally advanced esophageal cancer with acceptable complications.
EISSN:
 1471-2407
DOI:
10.1186/1471-2407-14-265
Keywords:
Esophageal cancer; Tomotherapy; Normal tissue sparing
Version:
Final published version
Additional Links:
http://www.biomedcentral.com/1471-2407/14/265

Full metadata record

DC FieldValue Language
dc.contributor.authorNguyen, Namen
dc.contributor.authorJang, Siyoungen
dc.contributor.authorVock, Jacquelineen
dc.contributor.authorVinh-Hung, Vincenten
dc.contributor.authorChi, Alexanderen
dc.contributor.authorVos, Paulen
dc.contributor.authorPugh, Judithen
dc.contributor.authorVo, Richarden
dc.contributor.authorCeizyk, Mistyen
dc.contributor.authorDesai, Ananden
dc.contributor.authorSmith-Raymond, Lexieen
dc.contributor.authorthe International Geriatric, Radiotherapy Groupen
dc.date.accessioned2016-05-20T09:04:52Z-
dc.date.available2016-05-20T09:04:52Z-
dc.date.issued2014en
dc.identifier.citationNguyen et al. BMC Cancer 2014, 14:265 http://www.biomedcentral.com/1471-2407/14/265en
dc.identifier.doi10.1186/1471-2407-14-265en
dc.identifier.urihttp://hdl.handle.net/10150/610350-
dc.description.abstractBACKGROUND:In this study the feasibility of intensity-modulated radiotherapy (IMRT) and tomotherapy-based image-guided radiotherapy (IGRT) for locally advanced esophageal cancer was assessed.METHODS:A retrospective study of ten patients with locally advanced esophageal cancer who underwent concurrent chemotherapy with IMRT (1) and IGRT (9) was conducted. The gross tumor volume was treated to a median dose of 70Gy (62.4-75Gy).RESULTS:At a median follow-up of 14months (1-39 months), three patients developed local failures, six patients developed distant metastases, and complications occurred in two patients (1 tracheoesophageal fistula, 1 esophageal stricture requiring repeated dilatations). No patients developed grade 3-4 pneumonitis or cardiac complications.CONCLUSIONS:IMRT and IGRT may be effective for the treatment of locally advanced esophageal cancer with acceptable complications.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urlhttp://www.biomedcentral.com/1471-2407/14/265en
dc.rights© 2014 Nguyen et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0)en
dc.subjectEsophageal canceren
dc.subjectTomotherapyen
dc.subjectNormal tissue sparingen
dc.titleFeasibility of intensity-modulated and image-guided radiotherapy for locally advanced esophageal canceren
dc.typeArticleen
dc.identifier.eissn 1471-2407en
dc.contributor.departmentDepartment of Radiation Oncology, Howard University Hospital, 2401 Georgia Avenue, N.W., Room 2055, Washington, DC 20060, USAen
dc.contributor.departmentDepartment of Radiation Oncology, Lindenhofspital, Bern, Switzerlanden
dc.contributor.departmentDepartment of Radiation Oncology, University Hospitals of Geneva, Geneva, Switzerlanden
dc.contributor.departmentDepartment of Radiation Oncology, University of West Virginia, Morgantown, WV, USAen
dc.contributor.departmentDepartment of Biostatistics, East Carolina University, Greenville, NC, USAen
dc.contributor.departmentDepartment of Pathology, University of Arizona, Tucson, AZ, USAen
dc.contributor.departmentDepartment of Pediatry, University of Virginia, Charlottesville, VA, USAen
dc.contributor.departmentDepartment of Radiation Oncology, Akron City Hospital, Akron, OH, USAen
dc.contributor.departmentDepartment of Radiation Oncology, University of Arizona, Tucson, AZ, USAen
dc.identifier.journalBMC Canceren
dc.description.collectioninformationThis item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen
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