Feasibility of image-guided radiotherapy based on helical tomotherapy to reduce contralateral parotid dose in head and neck cancer

Persistent Link:
http://hdl.handle.net/10150/610349
Title:
Feasibility of image-guided radiotherapy based on helical tomotherapy to reduce contralateral parotid dose in head and neck cancer
Author:
Nguyen, Nam; Vos, Paul; Vinh-Hung, Vincent; Ceizyk, Misty; Smith-Raymond, Lexie; Stevie, Michelle; Slane, Benjamin; Chi, Alexander; Desai, Anand; Krafft, Shane; Jang, Siyoung; Hamilton, Russ; Karlsson, Ulf; Abraham, Dave
Affiliation:
Department of Radiation Oncology, University of Arizona, Tucson, AZ, USA; Biostatistics, East Carolina University, Greenville, NC, USA; Department of Radiation Oncology, University Hospitals of Geneva, Geneva, Switzerland; Department of Radiation Oncology, University of West Virginia, Morgantown, VA, USA; Department of Radiation Oncology, University of Pittsburg, Pittsburg, PA, USA; Department of Radiation Oncology, Marshfield Clinic, Marshfield, WI, USA; University of Arizona, 1501 N. Campbell Ave., Tucson, AZ 85724-5081, USA
Issue Date:
2012
Publisher:
BioMed Central
Citation:
Nguyen et al. BMC Cancer 2012, 12:175 http://www.biomedcentral.com/1471-2407/12/175
Journal:
BMC Cancer
Rights:
© 2012 Nguyen et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0)
Collection Information:
This item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.
Abstract:
BACKGROUND:To evaluate the feasibility of image-guided radiotherapy based on helical Tomotherapy to spare the contralateral parotid gland in head and neck cancer patients with unilateral or no neck node metastases.METHODS:A retrospective review of 52 patients undergoing radiotherapy for head and neck cancers with image guidance based on daily megavoltage CT imaging with helical tomotherapy was performed.RESULTS:Mean contralateral parotid dose and the volume of the contralateral parotid receiving 40Gy or more were compared between radiotherapy plans with significant constraint (SC) of less than 20Gy on parotid dose (23 patients) and the conventional constraint (CC) of 26Gy (29 patients). All patients had PTV coverage of at least 95% to the contralateral elective neck nodes. Mean contralateral parotid dose was, respectively, 14.1Gy and 24.7Gy for the SC and CC plans (p<0.0001). The volume of contralateral parotid receiving 40Gy or more was respectively 5.3% and 18.2% (p<0.0001)CONCLUSION:Tomotherapy for head and neck cancer minimized radiotherapy dose to the contralateral parotid gland in patients undergoing elective node irradiation without sacrificing target coverage.
EISSN:
 1471-2407
DOI:
10.1186/1471-2407-12-175
Keywords:
Head and neck cancer; Tomotherapy; Parotid sparing
Version:
Final published version
Additional Links:
http://www.biomedcentral.com/1471-2407/12/175

Full metadata record

DC FieldValue Language
dc.contributor.authorNguyen, Namen
dc.contributor.authorVos, Paulen
dc.contributor.authorVinh-Hung, Vincenten
dc.contributor.authorCeizyk, Mistyen
dc.contributor.authorSmith-Raymond, Lexieen
dc.contributor.authorStevie, Michelleen
dc.contributor.authorSlane, Benjaminen
dc.contributor.authorChi, Alexanderen
dc.contributor.authorDesai, Ananden
dc.contributor.authorKrafft, Shaneen
dc.contributor.authorJang, Siyoungen
dc.contributor.authorHamilton, Russen
dc.contributor.authorKarlsson, Ulfen
dc.contributor.authorAbraham, Daveen
dc.date.accessioned2016-05-20T09:04:51Z-
dc.date.available2016-05-20T09:04:51Z-
dc.date.issued2012en
dc.identifier.citationNguyen et al. BMC Cancer 2012, 12:175 http://www.biomedcentral.com/1471-2407/12/175en
dc.identifier.doi10.1186/1471-2407-12-175en
dc.identifier.urihttp://hdl.handle.net/10150/610349-
dc.description.abstractBACKGROUND:To evaluate the feasibility of image-guided radiotherapy based on helical Tomotherapy to spare the contralateral parotid gland in head and neck cancer patients with unilateral or no neck node metastases.METHODS:A retrospective review of 52 patients undergoing radiotherapy for head and neck cancers with image guidance based on daily megavoltage CT imaging with helical tomotherapy was performed.RESULTS:Mean contralateral parotid dose and the volume of the contralateral parotid receiving 40Gy or more were compared between radiotherapy plans with significant constraint (SC) of less than 20Gy on parotid dose (23 patients) and the conventional constraint (CC) of 26Gy (29 patients). All patients had PTV coverage of at least 95% to the contralateral elective neck nodes. Mean contralateral parotid dose was, respectively, 14.1Gy and 24.7Gy for the SC and CC plans (p<0.0001). The volume of contralateral parotid receiving 40Gy or more was respectively 5.3% and 18.2% (p<0.0001)CONCLUSION:Tomotherapy for head and neck cancer minimized radiotherapy dose to the contralateral parotid gland in patients undergoing elective node irradiation without sacrificing target coverage.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urlhttp://www.biomedcentral.com/1471-2407/12/175en
dc.rights© 2012 Nguyen et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0)en
dc.subjectHead and neck canceren
dc.subjectTomotherapyen
dc.subjectParotid sparingen
dc.titleFeasibility of image-guided radiotherapy based on helical tomotherapy to reduce contralateral parotid dose in head and neck canceren
dc.typeArticleen
dc.identifier.eissn 1471-2407en
dc.contributor.departmentDepartment of Radiation Oncology, University of Arizona, Tucson, AZ, USAen
dc.contributor.departmentBiostatistics, East Carolina University, Greenville, NC, USAen
dc.contributor.departmentDepartment of Radiation Oncology, University Hospitals of Geneva, Geneva, Switzerlanden
dc.contributor.departmentDepartment of Radiation Oncology, University of West Virginia, Morgantown, VA, USAen
dc.contributor.departmentDepartment of Radiation Oncology, University of Pittsburg, Pittsburg, PA, USAen
dc.contributor.departmentDepartment of Radiation Oncology, Marshfield Clinic, Marshfield, WI, USAen
dc.contributor.departmentUniversity of Arizona, 1501 N. Campbell Ave., Tucson, AZ 85724-5081, USAen
dc.identifier.journalBMC Canceren
dc.description.collectioninformationThis item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen
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