Persistent Link:
http://hdl.handle.net/10150/610348
Title:
Effective use of TNF antagonists
Author:
Yocum, David
Affiliation:
University of Arizona Arthritis Center, Tucson, AZ, USA
Issue Date:
2004
Publisher:
BioMed Central
Citation:
Arthritis Res Ther 2004, 6(Suppl 2):S24-S30 (DOI 10.1186/ar997)
Journal:
Arthritis Research & Therapy
Rights:
© 2004 BioMed Central Ltd
Collection Information:
This item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.
Abstract:
Tumor necrosis factor (TNF) antagonists are biologic response modifiers that have significantly improved functional outcomes in patients with rheumatoid arthritis (RA). RA is a progressive disease in which structural joint damage can continue to develop even in the face of symptomatic relief. Before the introduction of biologic agents, the management of RA involved the use of disease-modifying antirheumatic drugs (DMARDs) early in the course of disease. This focus on early treatment, combined with the availability of the anti-TNF agents, has contributed to a shift in treatment paradigms favoring the early and timely use of DMARDs with biologic therapies. Improvement in symptom control does not always equate to a reduction in disease progression or disability. With the emergence of structure-related outcome measures as the primary means for assessing the effectiveness of antirheumatic agents, the regular use of X-rays is recommended for the continued monitoring and evaluation of patients. In addition to the control of symptoms and improvement in physical function, a reduction in erosions and joint-space narrowing should be considered among the goals of therapy, leading to a better quality of life. Adherence to therapy is an important element in optimizing outcomes. Durability of therapy with anti-TNF agents as reported from clinical trials can also be achieved in the clinical setting. Concomitant methotrexate therapy might be important in maintaining TNF antagonist therapy in the long term. Overall, the TNF antagonists have led to improvements in clinical and radiographic outcomes in patients with RA, especially those who have failed to show a complete response to methotrexate.
EISSN:
1478-6362
DOI:
10.1186/ar997
Keywords:
etanercept; infliximab; rheumatoid arthritis
Version:
Final published version
Additional Links:
http://arthritis-research.com/content/6/S2/S24

Full metadata record

DC FieldValue Language
dc.contributor.authorYocum, Daviden
dc.date.accessioned2016-05-20T09:04:50Z-
dc.date.available2016-05-20T09:04:50Z-
dc.date.issued2004en
dc.identifier.citationArthritis Res Ther 2004, 6(Suppl 2):S24-S30 (DOI 10.1186/ar997)en
dc.identifier.doi10.1186/ar997en
dc.identifier.urihttp://hdl.handle.net/10150/610348-
dc.description.abstractTumor necrosis factor (TNF) antagonists are biologic response modifiers that have significantly improved functional outcomes in patients with rheumatoid arthritis (RA). RA is a progressive disease in which structural joint damage can continue to develop even in the face of symptomatic relief. Before the introduction of biologic agents, the management of RA involved the use of disease-modifying antirheumatic drugs (DMARDs) early in the course of disease. This focus on early treatment, combined with the availability of the anti-TNF agents, has contributed to a shift in treatment paradigms favoring the early and timely use of DMARDs with biologic therapies. Improvement in symptom control does not always equate to a reduction in disease progression or disability. With the emergence of structure-related outcome measures as the primary means for assessing the effectiveness of antirheumatic agents, the regular use of X-rays is recommended for the continued monitoring and evaluation of patients. In addition to the control of symptoms and improvement in physical function, a reduction in erosions and joint-space narrowing should be considered among the goals of therapy, leading to a better quality of life. Adherence to therapy is an important element in optimizing outcomes. Durability of therapy with anti-TNF agents as reported from clinical trials can also be achieved in the clinical setting. Concomitant methotrexate therapy might be important in maintaining TNF antagonist therapy in the long term. Overall, the TNF antagonists have led to improvements in clinical and radiographic outcomes in patients with RA, especially those who have failed to show a complete response to methotrexate.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urlhttp://arthritis-research.com/content/6/S2/S24en
dc.rights© 2004 BioMed Central Ltden
dc.subjectetanercepten
dc.subjectinfliximaben
dc.subjectrheumatoid arthritisen
dc.titleEffective use of TNF antagonistsen
dc.typeArticleen
dc.identifier.eissn1478-6362en
dc.contributor.departmentUniversity of Arizona Arthritis Center, Tucson, AZ, USAen
dc.identifier.journalArthritis Research & Therapyen
dc.description.collectioninformationThis item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen
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