Pros and cons of CLA consumption: an insight from clinical evidences

Persistent Link:
http://hdl.handle.net/10150/610326
Title:
Pros and cons of CLA consumption: an insight from clinical evidences
Author:
Benjamin, Sailas; Prakasan, Priji; Sreedharan, Sajith; Wright, Andre-Denis G.; Spener, Friedrich
Affiliation:
Biotechnology Division, Department of Botany, Enzyme Technology Laboratory, University of Calicut; School of Animal and Comparative Biomedical Sciences, University of Arizona; Department of Molecular Biosciences, University of Graz
Issue Date:
2015
Publisher:
BioMed Central
Citation:
Benjamin et al. Nutrition & Metabolism 2015, 12:4 http://www.nutritionandmetabolism.com/content/12/1/4
Journal:
Nutrition & Metabolism
Rights:
© 2015 Benjamin et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0)
Collection Information:
This item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.
Abstract:
This comprehensive review critically evaluates whether supposed health benefits propounded upon human consumption of conjugated linoleic acids (CLAs) are clinically proven or not. With a general introduction on the chemistry of CLA, major clinical evidences pertaining to intervention strategies, body composition, cardio-vascular health, immunity, asthma, cancer and diabetes are evaluated. Supposed adverse effects such as oxidative stress, insulin resistance, irritation of intestinal tract and milk fat depression are also examined. It seems that no consistent result was observed even in similar studies conducted at different laboratories, this may be due to variations in age, gender, racial and geographical disparities, coupled with type and dose of CLA supplemented. Thus, supposed promising results reported in mechanistic and pre-clinical studies cannot be extrapolated with humans, mainly due to the lack of inconsistency in analyses, prolonged intervention studies, follow-up studies and international co-ordination of concerted studies. Briefly, clinical evidences accumulated thus far show that CLA is not eliciting significantly promising and consistent health effects so as to uphold it as neither a functional nor a medical food.
EISSN:
1743-7075
DOI:
10.1186/1743-7075-12-4
Keywords:
Conjugated linoleic acids; CLA; Review; Clinical evidences
Version:
Final published version
Additional Links:
http://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-12-4

Full metadata record

DC FieldValue Language
dc.contributor.authorBenjamin, Sailasen
dc.contributor.authorPrakasan, Prijien
dc.contributor.authorSreedharan, Sajithen
dc.contributor.authorWright, Andre-Denis G.en
dc.contributor.authorSpener, Friedrichen
dc.date.accessioned2016-05-20T09:04:16Z-
dc.date.available2016-05-20T09:04:16Z-
dc.date.issued2015en
dc.identifier.citationBenjamin et al. Nutrition & Metabolism 2015, 12:4 http://www.nutritionandmetabolism.com/content/12/1/4en
dc.identifier.doi10.1186/1743-7075-12-4en
dc.identifier.urihttp://hdl.handle.net/10150/610326-
dc.description.abstractThis comprehensive review critically evaluates whether supposed health benefits propounded upon human consumption of conjugated linoleic acids (CLAs) are clinically proven or not. With a general introduction on the chemistry of CLA, major clinical evidences pertaining to intervention strategies, body composition, cardio-vascular health, immunity, asthma, cancer and diabetes are evaluated. Supposed adverse effects such as oxidative stress, insulin resistance, irritation of intestinal tract and milk fat depression are also examined. It seems that no consistent result was observed even in similar studies conducted at different laboratories, this may be due to variations in age, gender, racial and geographical disparities, coupled with type and dose of CLA supplemented. Thus, supposed promising results reported in mechanistic and pre-clinical studies cannot be extrapolated with humans, mainly due to the lack of inconsistency in analyses, prolonged intervention studies, follow-up studies and international co-ordination of concerted studies. Briefly, clinical evidences accumulated thus far show that CLA is not eliciting significantly promising and consistent health effects so as to uphold it as neither a functional nor a medical food.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urlhttp://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-12-4en
dc.rights© 2015 Benjamin et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0)en
dc.subjectConjugated linoleic acidsen
dc.subjectCLAen
dc.subjectReviewen
dc.subjectClinical evidencesen
dc.titlePros and cons of CLA consumption: an insight from clinical evidencesen
dc.typeArticleen
dc.identifier.eissn1743-7075en
dc.contributor.departmentBiotechnology Division, Department of Botany, Enzyme Technology Laboratory, University of Calicuten
dc.contributor.departmentSchool of Animal and Comparative Biomedical Sciences, University of Arizonaen
dc.contributor.departmentDepartment of Molecular Biosciences, University of Grazen
dc.identifier.journalNutrition & Metabolismen
dc.description.collectioninformationThis item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen
All Items in UA Campus Repository are protected by copyright, with all rights reserved, unless otherwise indicated.