Violence: heightened brain attentional network response is selectively muted in Down syndrome

Persistent Link:
http://hdl.handle.net/10150/610322
Title:
Violence: heightened brain attentional network response is selectively muted in Down syndrome
Author:
Anderson, Jeffrey S.; Treiman, Scott M.; Ferguson, Michael A.; Nielsen, Jared A.; Edgin, Jamie O.; Dai, Li; Gerig, Guido; Korenberg, Julie R.
Affiliation:
Department of Radiology, 1A71 School of Medicine, University of Utah; Interdepartmental Program in Neuroscience, University of Utah; The Brain Institute at the University of Utah; Department of Bioengineering, University of Utah; Department of Psychology, University of Arizona; Department of Pediatrics, University of Utah; Scientific Computing and Imaging Institute, University of Utah
Issue Date:
2015
Publisher:
Springer
Citation:
Anderson et al. Journal of Neurodevelopmental Disorders (2015) 7:15 DOI 10.1186/s11689-015-9112-y
Journal:
Journal of Neurodevelopmental Disorders
Rights:
© 2015 Anderson et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0)
Collection Information:
This item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.
Abstract:
BACKGROUND: The ability to recognize and respond appropriately to threat is critical to survival, and the neural substrates subserving attention to threat may be probed using depictions of media violence. Whether neural responses to potential threat differ in Down syndrome is not known. METHODS: We performed functional MRI scans of 15 adolescent and adult Down syndrome and 14 typically developing individuals, group matched by age and gender, during 50 min of passive cartoon viewing. Brain activation to auditory and visual features, violence, and presence of the protagonist and antagonist were compared across cartoon segments. fMRI signal from the brain's dorsal attention network was compared to thematic and violent events within the cartoons between Down syndrome and control samples. RESULTS: We found that in typical development, the brain's dorsal attention network was most active during violent scenes in the cartoons and that this was significantly and specifically reduced in Down syndrome. When the antagonist was on screen, there was significantly less activation in the left medial temporal lobe of individuals with Down syndrome. As scenes represented greater relative threat, the disparity between attentional brain activation in Down syndrome and control individuals increased. There was a reduction in the temporal autocorrelation of the dorsal attention network, consistent with a shortened attention span in Down syndrome. Individuals with Down syndrome exhibited significantly reduced activation in primary sensory cortices, and such perceptual impairments may constrain their ability to respond to more complex social cues such as violence. CONCLUSIONS: These findings may indicate a relative deficit in emotive perception of violence in Down syndrome, possibly mediated by impaired sensory perception and hypoactivation of medial temporal structures in response to threats, with relative preservation of activity in pro-social brain regions. These findings indicate that specific genetic differences associated with Down syndrome can modulate the brain's response to violence and other complex emotive ideas.
EISSN:
1866-1955
DOI:
10.1186/s11689-015-9112-y
Keywords:
fMRI; Violence; Down syndrome; Attention
Version:
Final published version
Additional Links:
http://www.jneurodevdisorders.com/content/7/1/15

Full metadata record

DC FieldValue Language
dc.contributor.authorAnderson, Jeffrey S.en
dc.contributor.authorTreiman, Scott M.en
dc.contributor.authorFerguson, Michael A.en
dc.contributor.authorNielsen, Jared A.en
dc.contributor.authorEdgin, Jamie O.en
dc.contributor.authorDai, Lien
dc.contributor.authorGerig, Guidoen
dc.contributor.authorKorenberg, Julie R.en
dc.date.accessioned2016-05-20T09:04:10Z-
dc.date.available2016-05-20T09:04:10Z-
dc.date.issued2015en
dc.identifier.citationAnderson et al. Journal of Neurodevelopmental Disorders (2015) 7:15 DOI 10.1186/s11689-015-9112-yen
dc.identifier.doi10.1186/s11689-015-9112-yen
dc.identifier.urihttp://hdl.handle.net/10150/610322-
dc.description.abstractBACKGROUND: The ability to recognize and respond appropriately to threat is critical to survival, and the neural substrates subserving attention to threat may be probed using depictions of media violence. Whether neural responses to potential threat differ in Down syndrome is not known. METHODS: We performed functional MRI scans of 15 adolescent and adult Down syndrome and 14 typically developing individuals, group matched by age and gender, during 50 min of passive cartoon viewing. Brain activation to auditory and visual features, violence, and presence of the protagonist and antagonist were compared across cartoon segments. fMRI signal from the brain's dorsal attention network was compared to thematic and violent events within the cartoons between Down syndrome and control samples. RESULTS: We found that in typical development, the brain's dorsal attention network was most active during violent scenes in the cartoons and that this was significantly and specifically reduced in Down syndrome. When the antagonist was on screen, there was significantly less activation in the left medial temporal lobe of individuals with Down syndrome. As scenes represented greater relative threat, the disparity between attentional brain activation in Down syndrome and control individuals increased. There was a reduction in the temporal autocorrelation of the dorsal attention network, consistent with a shortened attention span in Down syndrome. Individuals with Down syndrome exhibited significantly reduced activation in primary sensory cortices, and such perceptual impairments may constrain their ability to respond to more complex social cues such as violence. CONCLUSIONS: These findings may indicate a relative deficit in emotive perception of violence in Down syndrome, possibly mediated by impaired sensory perception and hypoactivation of medial temporal structures in response to threats, with relative preservation of activity in pro-social brain regions. These findings indicate that specific genetic differences associated with Down syndrome can modulate the brain's response to violence and other complex emotive ideas.en
dc.language.isoenen
dc.publisherSpringeren
dc.relation.urlhttp://www.jneurodevdisorders.com/content/7/1/15en
dc.rights© 2015 Anderson et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0)en
dc.subjectfMRIen
dc.subjectViolenceen
dc.subjectDown syndromeen
dc.subjectAttentionen
dc.titleViolence: heightened brain attentional network response is selectively muted in Down syndromeen
dc.typeArticleen
dc.identifier.eissn1866-1955en
dc.contributor.departmentDepartment of Radiology, 1A71 School of Medicine, University of Utahen
dc.contributor.departmentInterdepartmental Program in Neuroscience, University of Utahen
dc.contributor.departmentThe Brain Institute at the University of Utahen
dc.contributor.departmentDepartment of Bioengineering, University of Utahen
dc.contributor.departmentDepartment of Psychology, University of Arizonaen
dc.contributor.departmentDepartment of Pediatrics, University of Utahen
dc.contributor.departmentScientific Computing and Imaging Institute, University of Utahen
dc.identifier.journalJournal of Neurodevelopmental Disordersen
dc.description.collectioninformationThis item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen
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