Neuroprotection in acute brain injury: an up-to-date review

Persistent Link:
http://hdl.handle.net/10150/610311
Title:
Neuroprotection in acute brain injury: an up-to-date review
Author:
Stocchetti, Nino; Taccone, Fabio S.; Citerio, Giuseppe; Pepe, Paul E.; Le Roux, Peter D.; Oddo, Mauro; Polderman, Kees H.; Stevens, Robert D.; Barsan, William; Maas, Andrew IR; Meyfroidt, Geert; Bell, Michael J.; Silbergleit, Robert; Vespa, Paul M.; Faden, Alan I.; Helbok, Raimund; Tisherman, Samuel; Zanier, Elisa R.; Valenzuela, Terence; Wendon, Julia; Menon, David K.; Vincent, Jean-Louis
Affiliation:
Department of Physiopathology and Transplant, Milan University; Neuro ICU, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico; Department of Intensive Care, Erasme Hospital, Université libre de Bruxelles; Department of Health Science, University of Milan-Bicocca, Ospedale San Gerardo; NeuroIntensive Care, Department of Emergency and Intensive Care, Ospedale San Gerardo; Department of Emergency Medicine, University of Texas Southwestern Medical Center at Dallas; Department of Neurosurgery, Lankenau Medical Center; Department of Intensive Care Medicine, Centre Hospitalier Universitaire Vaudois (CHUV) University Hospital, Faculty of Biology and Medicine, University of Lausanne; Department of Critical Care Medicine, University of Pittsburgh Medical Center; Division of Neuroscience Critical Care, Division of Adult Critical Care, Johns Hopkins Medicine; NETT Clinical Coordinating Center, University of Michigan; Department of Neurosurgery, University Hospital Antwerp and University of Antwerp; Department of Intensive Care, UZ Leuven, Campus Gasthuisberg; Department of Critical Care Medicine and the Safar Center for Resuscitation Research, University of Pittsburgh Medical Center; Department of Neurocritical Care, David Geffen School of Medicine at UCLA; Center for Shock, Trauma & Anesthesiology Research (STAR), University of Maryland School of Medicine; Department of Neurology, Neurocritical Care Unit, Innsbruck Medical University; Department of Surgery, R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine; IRCCS – Istituto di Ricerche Farmacologiche Mario Negri, Department of Neuroscience; Department of Emergency Medicine, University of Arizona; Institute of Liver Studies, King’s College Hospital; Division of Anaesthesia, University of Cambridge, Addenbrooke’s Hospital
Issue Date:
2015
Publisher:
BioMed Central Ltd
Citation:
Stocchetti et al. Critical Care (2015) 19:186 DOI 10.1186/s13054-015-0887-8
Journal:
Critical Care
Rights:
© 2015 Stocchetti et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0)
Collection Information:
This item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.
Abstract:
Neuroprotective strategies that limit secondary tissue loss and/or improve functional outcomes have been identified in multiple animal models of ischemic, hemorrhagic, traumatic and nontraumatic cerebral lesions. However, use of these potential interventions in human randomized controlled studies has generally given disappointing results. In this paper, we summarize the current status in terms of neuroprotective strategies, both in the immediate and later stages of acute brain injury in adults. We also review potential new strategies and highlight areas for future research.
EISSN:
1466-609X
DOI:
10.1186/s13054-015-0887-8
Version:
Final published version
Additional Links:
http://www.ccforum.com/content/19/1/186

Full metadata record

DC FieldValue Language
dc.contributor.authorStocchetti, Ninoen
dc.contributor.authorTaccone, Fabio S.en
dc.contributor.authorCiterio, Giuseppeen
dc.contributor.authorPepe, Paul E.en
dc.contributor.authorLe Roux, Peter D.en
dc.contributor.authorOddo, Mauroen
dc.contributor.authorPolderman, Kees H.en
dc.contributor.authorStevens, Robert D.en
dc.contributor.authorBarsan, Williamen
dc.contributor.authorMaas, Andrew IRen
dc.contributor.authorMeyfroidt, Geerten
dc.contributor.authorBell, Michael J.en
dc.contributor.authorSilbergleit, Roberten
dc.contributor.authorVespa, Paul M.en
dc.contributor.authorFaden, Alan I.en
dc.contributor.authorHelbok, Raimunden
dc.contributor.authorTisherman, Samuelen
dc.contributor.authorZanier, Elisa R.en
dc.contributor.authorValenzuela, Terenceen
dc.contributor.authorWendon, Juliaen
dc.contributor.authorMenon, David K.en
dc.contributor.authorVincent, Jean-Louisen
dc.date.accessioned2016-05-20T09:03:55Z-
dc.date.available2016-05-20T09:03:55Z-
dc.date.issued2015en
dc.identifier.citationStocchetti et al. Critical Care (2015) 19:186 DOI 10.1186/s13054-015-0887-8en
dc.identifier.doi10.1186/s13054-015-0887-8en
dc.identifier.urihttp://hdl.handle.net/10150/610311-
dc.description.abstractNeuroprotective strategies that limit secondary tissue loss and/or improve functional outcomes have been identified in multiple animal models of ischemic, hemorrhagic, traumatic and nontraumatic cerebral lesions. However, use of these potential interventions in human randomized controlled studies has generally given disappointing results. In this paper, we summarize the current status in terms of neuroprotective strategies, both in the immediate and later stages of acute brain injury in adults. We also review potential new strategies and highlight areas for future research.en
dc.language.isoenen
dc.publisherBioMed Central Ltden
dc.relation.urlhttp://www.ccforum.com/content/19/1/186en
dc.rights© 2015 Stocchetti et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0)en
dc.titleNeuroprotection in acute brain injury: an up-to-date reviewen
dc.typeArticleen
dc.identifier.eissn1466-609Xen
dc.contributor.departmentDepartment of Physiopathology and Transplant, Milan Universityen
dc.contributor.departmentNeuro ICU, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinicoen
dc.contributor.departmentDepartment of Intensive Care, Erasme Hospital, Université libre de Bruxellesen
dc.contributor.departmentDepartment of Health Science, University of Milan-Bicocca, Ospedale San Gerardoen
dc.contributor.departmentNeuroIntensive Care, Department of Emergency and Intensive Care, Ospedale San Gerardoen
dc.contributor.departmentDepartment of Emergency Medicine, University of Texas Southwestern Medical Center at Dallasen
dc.contributor.departmentDepartment of Neurosurgery, Lankenau Medical Centeren
dc.contributor.departmentDepartment of Intensive Care Medicine, Centre Hospitalier Universitaire Vaudois (CHUV) University Hospital, Faculty of Biology and Medicine, University of Lausanneen
dc.contributor.departmentDepartment of Critical Care Medicine, University of Pittsburgh Medical Centeren
dc.contributor.departmentDivision of Neuroscience Critical Care, Division of Adult Critical Care, Johns Hopkins Medicineen
dc.contributor.departmentNETT Clinical Coordinating Center, University of Michiganen
dc.contributor.departmentDepartment of Neurosurgery, University Hospital Antwerp and University of Antwerpen
dc.contributor.departmentDepartment of Intensive Care, UZ Leuven, Campus Gasthuisbergen
dc.contributor.departmentDepartment of Critical Care Medicine and the Safar Center for Resuscitation Research, University of Pittsburgh Medical Centeren
dc.contributor.departmentDepartment of Neurocritical Care, David Geffen School of Medicine at UCLAen
dc.contributor.departmentCenter for Shock, Trauma & Anesthesiology Research (STAR), University of Maryland School of Medicineen
dc.contributor.departmentDepartment of Neurology, Neurocritical Care Unit, Innsbruck Medical Universityen
dc.contributor.departmentDepartment of Surgery, R Adams Cowley Shock Trauma Center, University of Maryland School of Medicineen
dc.contributor.departmentIRCCS – Istituto di Ricerche Farmacologiche Mario Negri, Department of Neuroscienceen
dc.contributor.departmentDepartment of Emergency Medicine, University of Arizonaen
dc.contributor.departmentInstitute of Liver Studies, King’s College Hospitalen
dc.contributor.departmentDivision of Anaesthesia, University of Cambridge, Addenbrooke’s Hospitalen
dc.identifier.journalCritical Careen
dc.description.collectioninformationThis item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen
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