Persistent Link:
http://hdl.handle.net/10150/610309
Title:
Hsp90 depletion goes wild
Author:
Siegal, Mark; Masel, Joanna
Affiliation:
Center for Genomics and Systems Biology, Department of Biology, New York University, 12 Waverly Place, New York, NY 10003, USA; Department of Ecology and Evolutionary Biology, University of Arizona, 1041 E. Lowell St, Tucson, AZ 85721, USA
Issue Date:
2012
Publisher:
BioMed Central
Citation:
Siegal and Masel BMC Biology 2012, 10:14 http://www.biomedcentral.com/1741-7007/10/14
Journal:
BMC Biology
Rights:
© 2012 Siegal and Masel; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0)
Collection Information:
This item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.
Abstract:
Hsp90 reveals phenotypic variation in the laboratory, but is Hsp90 depletion important in the wild? Recent work from Chen and Wagner in BMC Evolutionary Biology has discovered a naturally occurring Drosophila allele that downregulates Hsp90, creating sensitivity to cryptic genetic variation. Laboratory studies suggest that the exact magnitude of Hsp90 downregulation is important. Extreme Hsp90 depletion might reactivate transposable elements and/or induce aneuploidy, in addition to revealing cryptic genetic variation.See research article http://wwww.biomedcentral.com/1471-2148/12/25 webcite
EISSN:
1741-7007
DOI:
10.1186/1741-7007-10-14
Version:
Final published version
Additional Links:
http://www.biomedcentral.com/1741-7007/10/14

Full metadata record

DC FieldValue Language
dc.contributor.authorSiegal, Marken
dc.contributor.authorMasel, Joannaen
dc.date.accessioned2016-05-20T09:03:52Z-
dc.date.available2016-05-20T09:03:52Z-
dc.date.issued2012en
dc.identifier.citationSiegal and Masel BMC Biology 2012, 10:14 http://www.biomedcentral.com/1741-7007/10/14en
dc.identifier.doi10.1186/1741-7007-10-14en
dc.identifier.urihttp://hdl.handle.net/10150/610309-
dc.description.abstractHsp90 reveals phenotypic variation in the laboratory, but is Hsp90 depletion important in the wild? Recent work from Chen and Wagner in BMC Evolutionary Biology has discovered a naturally occurring Drosophila allele that downregulates Hsp90, creating sensitivity to cryptic genetic variation. Laboratory studies suggest that the exact magnitude of Hsp90 downregulation is important. Extreme Hsp90 depletion might reactivate transposable elements and/or induce aneuploidy, in addition to revealing cryptic genetic variation.See research article http://wwww.biomedcentral.com/1471-2148/12/25 webciteen
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urlhttp://www.biomedcentral.com/1741-7007/10/14en
dc.rights© 2012 Siegal and Masel; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0)en
dc.titleHsp90 depletion goes wilden
dc.typeArticleen
dc.identifier.eissn1741-7007en
dc.contributor.departmentCenter for Genomics and Systems Biology, Department of Biology, New York University, 12 Waverly Place, New York, NY 10003, USAen
dc.contributor.departmentDepartment of Ecology and Evolutionary Biology, University of Arizona, 1041 E. Lowell St, Tucson, AZ 85721, USAen
dc.identifier.journalBMC Biologyen
dc.description.collectioninformationThis item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen
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