Hypocellular scar formation or aberrant fibrosis induced by an intrastromal corneal ring: a case report

Persistent Link:
http://hdl.handle.net/10150/610189
Title:
Hypocellular scar formation or aberrant fibrosis induced by an intrastromal corneal ring: a case report
Author:
Cao, Xiaoguang; Ursea, Roxana; Shen, Defen; Ramkumar, Hema; Chan, Chi-Chao
Affiliation:
Immunopathology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA; Department of Ophthalmology, People's Hospital, Peking University, Beijing, China; Department of Ophthalmology & Visual Science, University of Arizona, AZ, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA
Issue Date:
2011
Publisher:
BioMed Central
Citation:
Cao et al. Journal of Medical Case Reports 2011, 5:398 http://www.jmedicalcasereports.com/content/5/1/398
Journal:
Journal of Medical Case Reports
Rights:
© 2011 Cao et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0)
Collection Information:
This item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.
Abstract:
INTRODUCTION:Intrastromal corneal rings or segments are approved for the treatment of myopia and astigmatism associated with keratoconus. We describe a clinicopathological case of intrastromal corneal rings. For the first time, the molecular pathological findings of intrastromal corneal rings in the cornea are illustrated.CASE PRESENTATION:A 47-year-old African-American man with a history of keratoconus and failure in using a Rigid Gas Permeable contact lens received an intrastromal corneal ring implant in his left eye. Due to complications, penetrating keratoplasty was performed. The intrastromal corneal ring channels were surrounded by a dense acellular (channel haze) and/or hypocellular (acidophilic densification) collagen scar and slightly edematous keratocytes. Mild macrophage infiltration was found near the inner aspect of the intrastromal corneal rings. Molecular analyses of the microdissected cells surrounding the intrastromal corneal ring channels and central corneal stroma revealed 10 times lower relative expression of IP-10/CXCL10 mRNA and two times higher CCL5 mRNA in the cells surrounding the intrastromal corneal ring, as compared to the central corneal stroma. IP-10/CXCL10 is a fibrotic and angiostatic chemokine produced by macrophages, endothelial cells and fibroblasts.CONCLUSION:An intrastromal corneal ring implant can induce hypocellular scar formation and mild inflammation, which may result from aberrant release of fibrosis-related chemokines.
EISSN:
1752-1947
DOI:
10.1186/1752-1947-5-398
Version:
Final published version
Additional Links:
http://www.jmedicalcasereports.com/content/5/1/398

Full metadata record

DC FieldValue Language
dc.contributor.authorCao, Xiaoguangen
dc.contributor.authorUrsea, Roxanaen
dc.contributor.authorShen, Defenen
dc.contributor.authorRamkumar, Hemaen
dc.contributor.authorChan, Chi-Chaoen
dc.date.accessioned2016-05-20T09:00:37Z-
dc.date.available2016-05-20T09:00:37Z-
dc.date.issued2011en
dc.identifier.citationCao et al. Journal of Medical Case Reports 2011, 5:398 http://www.jmedicalcasereports.com/content/5/1/398en
dc.identifier.doi10.1186/1752-1947-5-398en
dc.identifier.urihttp://hdl.handle.net/10150/610189-
dc.description.abstractINTRODUCTION:Intrastromal corneal rings or segments are approved for the treatment of myopia and astigmatism associated with keratoconus. We describe a clinicopathological case of intrastromal corneal rings. For the first time, the molecular pathological findings of intrastromal corneal rings in the cornea are illustrated.CASE PRESENTATION:A 47-year-old African-American man with a history of keratoconus and failure in using a Rigid Gas Permeable contact lens received an intrastromal corneal ring implant in his left eye. Due to complications, penetrating keratoplasty was performed. The intrastromal corneal ring channels were surrounded by a dense acellular (channel haze) and/or hypocellular (acidophilic densification) collagen scar and slightly edematous keratocytes. Mild macrophage infiltration was found near the inner aspect of the intrastromal corneal rings. Molecular analyses of the microdissected cells surrounding the intrastromal corneal ring channels and central corneal stroma revealed 10 times lower relative expression of IP-10/CXCL10 mRNA and two times higher CCL5 mRNA in the cells surrounding the intrastromal corneal ring, as compared to the central corneal stroma. IP-10/CXCL10 is a fibrotic and angiostatic chemokine produced by macrophages, endothelial cells and fibroblasts.CONCLUSION:An intrastromal corneal ring implant can induce hypocellular scar formation and mild inflammation, which may result from aberrant release of fibrosis-related chemokines.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urlhttp://www.jmedicalcasereports.com/content/5/1/398en
dc.rights© 2011 Cao et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0)en
dc.titleHypocellular scar formation or aberrant fibrosis induced by an intrastromal corneal ring: a case reporten
dc.typeArticleen
dc.identifier.eissn1752-1947en
dc.contributor.departmentImmunopathology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USAen
dc.contributor.departmentDepartment of Ophthalmology, People's Hospital, Peking University, Beijing, Chinaen
dc.contributor.departmentDepartment of Ophthalmology & Visual Science, University of Arizona, AZ, USAen
dc.contributor.departmentHoward Hughes Medical Institute, Chevy Chase, MD, USAen
dc.identifier.journalJournal of Medical Case Reportsen
dc.description.collectioninformationThis item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen
All Items in UA Campus Repository are protected by copyright, with all rights reserved, unless otherwise indicated.