Lynch syndrome related endometrial cancer: clinical significance beyond the endometrium

Persistent Link:
http://hdl.handle.net/10150/610184
Title:
Lynch syndrome related endometrial cancer: clinical significance beyond the endometrium
Author:
Wang, Yiying; Wang, Yue; Li, Jie; Cragun, Janiel; Hatch, Kenneth; Chambers, Setsuko; Zheng, Wenxin
Affiliation:
Department of Obstetrics and Gynecology, Henan Province People’s Hospital Zhengzhou, Henan, China; Department of Obstetrics and Gynecology, University of Arizona, Tucson, AZ, USA; Department of Pathology, University of Arizona College of Medicine, Tucson, AZ, USA; Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Shandong, China; Arizona Cancer Center, University of Arizona, Tucson, AZ, USA
Issue Date:
2013
Publisher:
BioMed Central
Citation:
Wang et al. Journal of Hematology & Oncology 2013, 6:22 http://www.jhoonline.org/content/6/1/22
Journal:
Journal of Hematology & Oncology
Rights:
© 2013 Wang et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0)
Collection Information:
This item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.
Abstract:
Lynch syndrome (LS), an autosomal dominant inherited cancer susceptibility syndrome, also known as hereditary non-polyposis colon cancer (HNPCC), is caused by a germline mutation in one of several DNA mismatch repair (MMR) genes. LS is the most common presentation of hereditary colorectal cancer (CRC), accounting for about 2-5% of all CRC cases. More recently, it is found that a similar number of endometrial cancers is also due to one of the MMR gene mutations. There has been significant progress in LS-related CRC in terms of molecular pathogenesis, risks, genetic basis, and cancer prevention. In contrast, the advance about LS-related endometrial cancer (EC) is very much limited. In this commentary, we summarize the main clinicopathologic features of LS-related EC and propose universal screening for LS in individuals with endometrial cancer.
EISSN:
1756-8722
DOI:
10.1186/1756-8722-6-22
Version:
Final published version
Additional Links:
http://www.jhoonline.org/content/6/1/22

Full metadata record

DC FieldValue Language
dc.contributor.authorWang, Yiyingen
dc.contributor.authorWang, Yueen
dc.contributor.authorLi, Jieen
dc.contributor.authorCragun, Janielen
dc.contributor.authorHatch, Kennethen
dc.contributor.authorChambers, Setsukoen
dc.contributor.authorZheng, Wenxinen
dc.date.accessioned2016-05-20T09:00:32Z-
dc.date.available2016-05-20T09:00:32Z-
dc.date.issued2013en
dc.identifier.citationWang et al. Journal of Hematology & Oncology 2013, 6:22 http://www.jhoonline.org/content/6/1/22en
dc.identifier.doi10.1186/1756-8722-6-22en
dc.identifier.urihttp://hdl.handle.net/10150/610184-
dc.description.abstractLynch syndrome (LS), an autosomal dominant inherited cancer susceptibility syndrome, also known as hereditary non-polyposis colon cancer (HNPCC), is caused by a germline mutation in one of several DNA mismatch repair (MMR) genes. LS is the most common presentation of hereditary colorectal cancer (CRC), accounting for about 2-5% of all CRC cases. More recently, it is found that a similar number of endometrial cancers is also due to one of the MMR gene mutations. There has been significant progress in LS-related CRC in terms of molecular pathogenesis, risks, genetic basis, and cancer prevention. In contrast, the advance about LS-related endometrial cancer (EC) is very much limited. In this commentary, we summarize the main clinicopathologic features of LS-related EC and propose universal screening for LS in individuals with endometrial cancer.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urlhttp://www.jhoonline.org/content/6/1/22en
dc.rights© 2013 Wang et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0)en
dc.titleLynch syndrome related endometrial cancer: clinical significance beyond the endometriumen
dc.typeArticleen
dc.identifier.eissn1756-8722en
dc.contributor.departmentDepartment of Obstetrics and Gynecology, Henan Province People’s Hospital Zhengzhou, Henan, Chinaen
dc.contributor.departmentDepartment of Obstetrics and Gynecology, University of Arizona, Tucson, AZ, USAen
dc.contributor.departmentDepartment of Pathology, University of Arizona College of Medicine, Tucson, AZ, USAen
dc.contributor.departmentDepartment of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Shandong, Chinaen
dc.contributor.departmentArizona Cancer Center, University of Arizona, Tucson, AZ, USAen
dc.identifier.journalJournal of Hematology & Oncologyen
dc.description.collectioninformationThis item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen
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