Ovarian serous carcinoma: recent concepts on its origin and carcinogenesis

Persistent Link:
http://hdl.handle.net/10150/610182
Title:
Ovarian serous carcinoma: recent concepts on its origin and carcinogenesis
Author:
Li, Jie; Fadare, Oluwole; Xiang, Li; Kong, Beihua; Zheng, Wenxin
Affiliation:
Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, 107 W. Wenhua Road, Jinan, Shandong, China 250012; Department of Pathology, University of Arizona College of Medicine, Tucson, AZ, USA; Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA; Department of Obstetrics and Gynecology, University of Arizona, Tucson, AZ, USA; Arizona Cancer Center, University of Arizona, Tucson, AZ, USA; Department of Pathology, University of Arizona, 1501 N. Campbell Avenue, #5224A, Tucson, AZ 85724, USA
Issue Date:
2012
Publisher:
BioMed Central
Citation:
Li et al. Journal of Hematology & Oncology 2012, 5:8 http://www.jhoonline.org/content/5/1/8
Journal:
Journal of Hematology & Oncology
Rights:
© 2012 Li et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0)
Collection Information:
This item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.
Abstract:
Recent morphologic and molecular genetic studies have led to a paradigm shift in our conceptualization of the carcinogenesis and histogenesis of pelvic (non-uterine) serous carcinomas. It appears that both low-grade and high-grade pelvic serous carcinomas that have traditionally been classified as ovarian in origin, actually originate, at least in a significant subset, from the distal fallopian tube. Clonal expansions of the tubal secretory cell probably give rise to serous carcinomas, and the degree of ciliated conversion is a function of the degree to which the genetic hits deregulate normal differentiation. In this article, the authors review the evidentiary basis for aforementioned paradigm shift, as well as its potential clinical implications.
EISSN:
1756-8722
DOI:
10.1186/1756-8722-5-8
Keywords:
Ovarian cancer; Fallopian tube; Carcinogenesis; Serous carcinoma; p53 signatures
Version:
Final published version
Additional Links:
http://www.jhoonline.org/content/5/1/8

Full metadata record

DC FieldValue Language
dc.contributor.authorLi, Jieen
dc.contributor.authorFadare, Oluwoleen
dc.contributor.authorXiang, Lien
dc.contributor.authorKong, Beihuaen
dc.contributor.authorZheng, Wenxinen
dc.date.accessioned2016-05-20T09:00:29Z-
dc.date.available2016-05-20T09:00:29Z-
dc.date.issued2012en
dc.identifier.citationLi et al. Journal of Hematology & Oncology 2012, 5:8 http://www.jhoonline.org/content/5/1/8en
dc.identifier.doi10.1186/1756-8722-5-8en
dc.identifier.urihttp://hdl.handle.net/10150/610182-
dc.description.abstractRecent morphologic and molecular genetic studies have led to a paradigm shift in our conceptualization of the carcinogenesis and histogenesis of pelvic (non-uterine) serous carcinomas. It appears that both low-grade and high-grade pelvic serous carcinomas that have traditionally been classified as ovarian in origin, actually originate, at least in a significant subset, from the distal fallopian tube. Clonal expansions of the tubal secretory cell probably give rise to serous carcinomas, and the degree of ciliated conversion is a function of the degree to which the genetic hits deregulate normal differentiation. In this article, the authors review the evidentiary basis for aforementioned paradigm shift, as well as its potential clinical implications.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urlhttp://www.jhoonline.org/content/5/1/8en
dc.rights© 2012 Li et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0)en
dc.subjectOvarian canceren
dc.subjectFallopian tubeen
dc.subjectCarcinogenesisen
dc.subjectSerous carcinomaen
dc.subjectp53 signaturesen
dc.titleOvarian serous carcinoma: recent concepts on its origin and carcinogenesisen
dc.typeArticleen
dc.identifier.eissn1756-8722en
dc.contributor.departmentDepartment of Obstetrics and Gynecology, Qilu Hospital, Shandong University, 107 W. Wenhua Road, Jinan, Shandong, China 250012en
dc.contributor.departmentDepartment of Pathology, University of Arizona College of Medicine, Tucson, AZ, USAen
dc.contributor.departmentDepartment of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USAen
dc.contributor.departmentDepartment of Obstetrics and Gynecology, University of Arizona, Tucson, AZ, USAen
dc.contributor.departmentArizona Cancer Center, University of Arizona, Tucson, AZ, USAen
dc.contributor.departmentDepartment of Pathology, University of Arizona, 1501 N. Campbell Avenue, #5224A, Tucson, AZ 85724, USAen
dc.identifier.journalJournal of Hematology & Oncologyen
dc.description.collectioninformationThis item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen
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