Mild hypothermia delays the development of stone heart from untreated sustained ventricular fibrillation - a cardiovascular magnetic resonance study

Persistent Link:
http://hdl.handle.net/10150/610178
Title:
Mild hypothermia delays the development of stone heart from untreated sustained ventricular fibrillation - a cardiovascular magnetic resonance study
Author:
Sorrell, Vincent; Paleru, Vijayasree; Altbach, Maria; Hilwig, Ronald; Kern, Karl; Gaballa, Mohamed; Ewy, Gordon; Berg, Robert
Affiliation:
Department of Medicine, Sarver Heart Center, University of Arizona College of Medicine, Tucson, Arizona, USA; Department of Radiology, University of Arizona College of Medicine, Tucson, Arizona, USA; Department of Pediatrics, Steel Memorial Children Research Center, University of Arizona College of Medicine, Tucson, Arizona, USA
Issue Date:
2011
Publisher:
BioMed Central
Citation:
Sorrell et al. Journal of Cardiovascular Magnetic Resonance 2011, 13:17 http://www.jcmr-online.com/content/13/1/17
Journal:
Journal of Cardiovascular Magnetic Resonance
Rights:
© 2011 Sorrell et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0)
Collection Information:
This item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.
Abstract:
BACKGROUND:'Stone heart' resulting from ischemic contracture of the myocardium, precludes successful resuscitation from ventricular fibrillation (VF). We hypothesized that mild hypothermia might slow the progression to stone heart.METHODS:Fourteen swine (27 +/- 1 kg) were randomized to normothermia (group I; n = 6) or hypothermia groups (group II; n = 8). Mild hypothermia (34 +/- 2degreesC) was induced with ice packs prior to VF induction. The LV and right ventricular (RV) cross-sectional areas were followed by cardiovascular magnetic resonance until the development of stone heart. A commercial 1.5T GE Signa NV-CV/i scanner was used. Complete anatomic coverage of the heart was acquired using a steady-state free precession (SSFP) pulse sequence gated at baseline prior to VF onset. Un-gated SSFP images were obtained serially after VF induction. The ventricular endocardium was manually traced and LV and RV volumes were calculated at each time point.RESULTS:In group I, the LV was dilated compared to baseline at 5 minutes after VF and this remained for 20 minutes. Stone heart, arbitrarily defined as LV volume <1/3 of baseline at the onset of VF, occurred at 29 +/- 3 minutes. In group II, there was less early dilation of the LV (p < 0.05) and the development of stone heart was delayed to 52 +/- 4 minutes after onset of VF (P < 0.001).CONCLUSIONS:In this closed-chest swine model of prolonged untreated VF, hypothermia reduced the early LV dilatation and importantly, delayed the onset of stone heart thereby extending a known, morphologic limit of resuscitability.
EISSN:
1532-429X
DOI:
10.1186/1532-429X-13-17
Version:
Final published version
Additional Links:
http://www.jcmr-online.com/content/13/1/17

Full metadata record

DC FieldValue Language
dc.contributor.authorSorrell, Vincenten
dc.contributor.authorPaleru, Vijayasreeen
dc.contributor.authorAltbach, Mariaen
dc.contributor.authorHilwig, Ronalden
dc.contributor.authorKern, Karlen
dc.contributor.authorGaballa, Mohameden
dc.contributor.authorEwy, Gordonen
dc.contributor.authorBerg, Roberten
dc.date.accessioned2016-05-20T09:00:24Z-
dc.date.available2016-05-20T09:00:24Z-
dc.date.issued2011en
dc.identifier.citationSorrell et al. Journal of Cardiovascular Magnetic Resonance 2011, 13:17 http://www.jcmr-online.com/content/13/1/17en
dc.identifier.doi10.1186/1532-429X-13-17en
dc.identifier.urihttp://hdl.handle.net/10150/610178-
dc.description.abstractBACKGROUND:'Stone heart' resulting from ischemic contracture of the myocardium, precludes successful resuscitation from ventricular fibrillation (VF). We hypothesized that mild hypothermia might slow the progression to stone heart.METHODS:Fourteen swine (27 +/- 1 kg) were randomized to normothermia (group Ien
dc.description.abstractn = 6) or hypothermia groups (group IIen
dc.description.abstractn = 8). Mild hypothermia (34 +/- 2degreesC) was induced with ice packs prior to VF induction. The LV and right ventricular (RV) cross-sectional areas were followed by cardiovascular magnetic resonance until the development of stone heart. A commercial 1.5T GE Signa NV-CV/i scanner was used. Complete anatomic coverage of the heart was acquired using a steady-state free precession (SSFP) pulse sequence gated at baseline prior to VF onset. Un-gated SSFP images were obtained serially after VF induction. The ventricular endocardium was manually traced and LV and RV volumes were calculated at each time point.RESULTS:In group I, the LV was dilated compared to baseline at 5 minutes after VF and this remained for 20 minutes. Stone heart, arbitrarily defined as LV volume <1/3 of baseline at the onset of VF, occurred at 29 +/- 3 minutes. In group II, there was less early dilation of the LV (p < 0.05) and the development of stone heart was delayed to 52 +/- 4 minutes after onset of VF (P < 0.001).CONCLUSIONS:In this closed-chest swine model of prolonged untreated VF, hypothermia reduced the early LV dilatation and importantly, delayed the onset of stone heart thereby extending a known, morphologic limit of resuscitability.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urlhttp://www.jcmr-online.com/content/13/1/17en
dc.rights© 2011 Sorrell et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0)en
dc.titleMild hypothermia delays the development of stone heart from untreated sustained ventricular fibrillation - a cardiovascular magnetic resonance studyen
dc.typeArticleen
dc.identifier.eissn1532-429Xen
dc.contributor.departmentDepartment of Medicine, Sarver Heart Center, University of Arizona College of Medicine, Tucson, Arizona, USAen
dc.contributor.departmentDepartment of Radiology, University of Arizona College of Medicine, Tucson, Arizona, USAen
dc.contributor.departmentDepartment of Pediatrics, Steel Memorial Children Research Center, University of Arizona College of Medicine, Tucson, Arizona, USAen
dc.identifier.journalJournal of Cardiovascular Magnetic Resonanceen
dc.description.collectioninformationThis item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen
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