Persufflation (gaseous oxygen perfusion) as a method of heart preservation
Author
Suszynski, ThomasRizzari, Michael
Scott, William
Eckman, Peter
Fonger, James
John, Ranjit
Chronos, Nicolas
Tempelman, Linda
Sutherland, David E. R.
Papas, Klearchos
Affiliation
Division of Transplantation, Department of Surgery, University of Minnesota, Minneapolis, MN, USADepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA
Institute for Cellular Transplantation, Department of Surgery, University of Arizona, 1656 E. Mabel Street, Room 121, Tucson, AZ 85724, USA
Division of Cardiovascular Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA
St. Josephs Translational Research Institute, Atlanta, GA, USA
Division of Cardiothoracic Surgery, Department of Surgery, University of Minnesota, Minneapolis, MN, USA
Giner Inc, Newton, MA, USA
Issue Date
2013
Metadata
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BioMed CentralCitation
Suszynski et al. Journal of Cardiothoracic Surgery 2013, 8:105 http://www.cardiothoracicsurgery.org/content/8/1/105Rights
© 2013 Suszynski et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0).Collection Information
This item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.Abstract
Persufflation (PSF; gaseous oxygen perfusion) is an organ preservation technique with a potential for use in donor heart preservation. Improved heart preservation with PSF may improve outcomes by maintaining cardiac tissue quality in the setting of longer cold ischemia times and possibly increasing the number of donor hearts available for allotransplant. Published data suggest that PSF is able to extend the cold storage times for porcine hearts up to 14 hours without compromising viability and function, and has been shown to resuscitate porcine hearts following donation after cardiac death. This review summarizes key published work on heart PSF, including prospective implications and future directions for PSF in heart transplantation. We emphasize the potential impact of extending preservation times and expanding donor selection criteria in heart allotransplant. Additionally, the key issues that need to be addressed before PSF were to become a widely utilized preservation strategy prior to clinical heart transplantation are summarized and discussed.EISSN
1749-8090Version
Final published versionAdditional Links
http://www.cardiothoracicsurgery.org/content/8/1/105ae974a485f413a2113503eed53cd6c53
10.1186/1749-8090-8-105
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Except where otherwise noted, this item's license is described as © 2013 Suszynski et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0).