Persufflation (gaseous oxygen perfusion) as a method of heart preservation

Persistent Link:
http://hdl.handle.net/10150/610177
Title:
Persufflation (gaseous oxygen perfusion) as a method of heart preservation
Author:
Suszynski, Thomas; Rizzari, Michael; Scott, William; Eckman, Peter; Fonger, James; John, Ranjit; Chronos, Nicolas; Tempelman, Linda; Sutherland, David E. R.; Papas, Klearchos
Affiliation:
Division of Transplantation, Department of Surgery, University of Minnesota, Minneapolis, MN, USA; Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA; Institute for Cellular Transplantation, Department of Surgery, University of Arizona, 1656 E. Mabel Street, Room 121, Tucson, AZ 85724, USA; Division of Cardiovascular Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA; St. Josephs Translational Research Institute, Atlanta, GA, USA; Division of Cardiothoracic Surgery, Department of Surgery, University of Minnesota, Minneapolis, MN, USA; Giner Inc, Newton, MA, USA
Issue Date:
2013
Publisher:
BioMed Central
Citation:
Suszynski et al. Journal of Cardiothoracic Surgery 2013, 8:105 http://www.cardiothoracicsurgery.org/content/8/1/105
Journal:
Journal of Cardiothoracic Surgery
Rights:
© 2013 Suszynski et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0)
Collection Information:
This item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.
Abstract:
Persufflation (PSF; gaseous oxygen perfusion) is an organ preservation technique with a potential for use in donor heart preservation. Improved heart preservation with PSF may improve outcomes by maintaining cardiac tissue quality in the setting of longer cold ischemia times and possibly increasing the number of donor hearts available for allotransplant. Published data suggest that PSF is able to extend the cold storage times for porcine hearts up to 14 hours without compromising viability and function, and has been shown to resuscitate porcine hearts following donation after cardiac death. This review summarizes key published work on heart PSF, including prospective implications and future directions for PSF in heart transplantation. We emphasize the potential impact of extending preservation times and expanding donor selection criteria in heart allotransplant. Additionally, the key issues that need to be addressed before PSF were to become a widely utilized preservation strategy prior to clinical heart transplantation are summarized and discussed.
EISSN:
1749-8090
DOI:
10.1186/1749-8090-8-105
Keywords:
Organ preservation; Heart transplantation; Ischemia; Perfusion
Version:
Final published version
Additional Links:
http://www.cardiothoracicsurgery.org/content/8/1/105

Full metadata record

DC FieldValue Language
dc.contributor.authorSuszynski, Thomasen
dc.contributor.authorRizzari, Michaelen
dc.contributor.authorScott, Williamen
dc.contributor.authorEckman, Peteren
dc.contributor.authorFonger, Jamesen
dc.contributor.authorJohn, Ranjiten
dc.contributor.authorChronos, Nicolasen
dc.contributor.authorTempelman, Lindaen
dc.contributor.authorSutherland, David E. R.en
dc.contributor.authorPapas, Klearchosen
dc.date.accessioned2016-05-20T09:00:22Z-
dc.date.available2016-05-20T09:00:22Z-
dc.date.issued2013en
dc.identifier.citationSuszynski et al. Journal of Cardiothoracic Surgery 2013, 8:105 http://www.cardiothoracicsurgery.org/content/8/1/105en
dc.identifier.doi10.1186/1749-8090-8-105en
dc.identifier.urihttp://hdl.handle.net/10150/610177-
dc.description.abstractPersufflation (PSF; gaseous oxygen perfusion) is an organ preservation technique with a potential for use in donor heart preservation. Improved heart preservation with PSF may improve outcomes by maintaining cardiac tissue quality in the setting of longer cold ischemia times and possibly increasing the number of donor hearts available for allotransplant. Published data suggest that PSF is able to extend the cold storage times for porcine hearts up to 14 hours without compromising viability and function, and has been shown to resuscitate porcine hearts following donation after cardiac death. This review summarizes key published work on heart PSF, including prospective implications and future directions for PSF in heart transplantation. We emphasize the potential impact of extending preservation times and expanding donor selection criteria in heart allotransplant. Additionally, the key issues that need to be addressed before PSF were to become a widely utilized preservation strategy prior to clinical heart transplantation are summarized and discussed.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urlhttp://www.cardiothoracicsurgery.org/content/8/1/105en
dc.rights© 2013 Suszynski et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0)en
dc.subjectOrgan preservationen
dc.subjectHeart transplantationen
dc.subjectIschemiaen
dc.subjectPerfusionen
dc.titlePersufflation (gaseous oxygen perfusion) as a method of heart preservationen
dc.typeArticleen
dc.identifier.eissn1749-8090en
dc.contributor.departmentDivision of Transplantation, Department of Surgery, University of Minnesota, Minneapolis, MN, USAen
dc.contributor.departmentDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USAen
dc.contributor.departmentInstitute for Cellular Transplantation, Department of Surgery, University of Arizona, 1656 E. Mabel Street, Room 121, Tucson, AZ 85724, USAen
dc.contributor.departmentDivision of Cardiovascular Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USAen
dc.contributor.departmentSt. Josephs Translational Research Institute, Atlanta, GA, USAen
dc.contributor.departmentDivision of Cardiothoracic Surgery, Department of Surgery, University of Minnesota, Minneapolis, MN, USAen
dc.contributor.departmentGiner Inc, Newton, MA, USAen
dc.identifier.journalJournal of Cardiothoracic Surgeryen
dc.description.collectioninformationThis item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen
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