CMV and Immunosenescence: from basics to clinics

Persistent Link:
http://hdl.handle.net/10150/610158
Title:
CMV and Immunosenescence: from basics to clinics
Author:
Solana, Rafael; Tarazona, Raquel; Aiello, Allison; Akbar, Arne; Appay, Victor; Beswick, Mark; Bosch, Jos; Campos, Carmen; Cantisan, Sara; Cicin-Sain, Luka; Derhovanessian, Evelyna; Ferrando-Martinez, Sara; Frasca, Daniela; Fulop, Tamas; Govind, Sheila; Grubeck-Loebenstein, Beatrix; Hill, Ann; Hurme, Mikko; Kern, Florian; Larbi, Anis; Lopez-Botet, Miguel; Maier, Andrea; McElhaney, Janet; Moss, Paul; Naumova, Elissaveta; Nikolich-Zugich, Janko; Pera, Alejandra; Rector, Jerrald; Riddell, Natalie; Sanchez-Correa, Beatriz; Sansoni, Paolo; Sauce, Delphine; van Lier, Rene; Wang, George; Wills, Mark; Zielinski, Maciej; Pawelec, Graham
Affiliation:
Immunology Unit, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)-Reina Sofia University Hospital-University of Cordoba, Cordoba, Spain; Immunology Unit, Department of Physiology, University of Extremadura, Caceres, Spain; University of Michigan, Department of Epidemiology, Center for Social Epidemiology and Population Health, Ann Arbor, Michigan, USA; Division of Infection and Immunity, University College London, London, UK; Infections and Immunity, Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France; School of Cancer Sciences, University of Birmingham, Birmingham, UK; University of Amsterdam, Amsterdam, The Netherlands; Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany; Department of Internal Medicine II, Center for Medical Research, University of Tübingen, Tübingen, Germany; Laboratory of Molecular Immune-Biology, Hospital General Universitario Gregorio Marañón, Madrid and Laboratory of Immunovirology; Infectious Diseases Service, IBiS, Seville, Spain; Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida, USA; Research Center on Aging, Sherbrooke, Canada; Regenerative Medicine Group, Cranfield Health, Cranfield University, Cranfield, UK; Institute for Biomedical Aging Research, University of Innsbruck, Innsbruck, Austria; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon, USA; University of Tampere, Medical School, Tampere, Finland; Brighton and Sussex Medical School, Brighton, UK; Singapore Immunology Network, Singapore, Singapore; IMIM (Hospital del Mar Research Institute), Univ. Pompeu Fabra, Barcelona, Spain; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands; University of British Columbia, Vancouver, Canada; Department of Clinical Immunology, University Hospital Alexandrovska, Sofia, Bulgaria; Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, Arizona, USA; University of Birmingham, Birmingham, UK; Department of Internal Medicine and Biomedical Sciences, University of Parma, Parma, Italy; Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands; Division of Geriatric Medicine and Gerontology, Biology of Healthy Aging Program, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; University of Cambridge Department of Medicine Addenbrookes Hospital, Cambridge, UK; Department of Clinical Immunology and Transplantology, Medical University of Gdansk, Gdansk, Poland; Mannheim Institute of Public Health, Social and Preventive Medicine (MIPH), University of Heidelberg, Mannheim Medical Faculty, Mannheim, Germany
Issue Date:
2012
Publisher:
BioMed Central
Citation:
Solana et al. Immunity & Ageing 2012, 9:23 http://www.immunityageing.com/content/9/1/23
Journal:
Immunity & Ageing
Rights:
© 2012 Solana et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0)
Collection Information:
This item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.
Abstract:
Alone among herpesviruses, persistent Cytomegalovirus (CMV) markedly alters the numbers and proportions of peripheral immune cells in infected-vs-uninfected people. Because the rate of CMV infection increases with age in most countries, it has been suggested that it drives or at least exacerbates "immunosenescence". This contention remains controversial and was the primary subject of the Third International Workshop on CMV & Immunosenescence which was held in Cordoba, Spain, 15-16th March, 2012. Discussions focused on several main themes including the effects of CMV on adaptive immunity and immunosenescence, characterization of CMV-specific T cells, impact of CMV infection and ageing on innate immunity, and finally, most important, the clinical implications of immunosenescence and CMV infection. Here we summarize the major findings of this workshop.
EISSN:
1742-4933
DOI:
10.1186/1742-4933-9-23
Version:
Final published version
Additional Links:
http://www.immunityageing.com/content/9/1/23

Full metadata record

DC FieldValue Language
dc.contributor.authorSolana, Rafaelen
dc.contributor.authorTarazona, Raquelen
dc.contributor.authorAiello, Allisonen
dc.contributor.authorAkbar, Arneen
dc.contributor.authorAppay, Victoren
dc.contributor.authorBeswick, Marken
dc.contributor.authorBosch, Josen
dc.contributor.authorCampos, Carmenen
dc.contributor.authorCantisan, Saraen
dc.contributor.authorCicin-Sain, Lukaen
dc.contributor.authorDerhovanessian, Evelynaen
dc.contributor.authorFerrando-Martinez, Saraen
dc.contributor.authorFrasca, Danielaen
dc.contributor.authorFulop, Tamasen
dc.contributor.authorGovind, Sheilaen
dc.contributor.authorGrubeck-Loebenstein, Beatrixen
dc.contributor.authorHill, Annen
dc.contributor.authorHurme, Mikkoen
dc.contributor.authorKern, Florianen
dc.contributor.authorLarbi, Anisen
dc.contributor.authorLopez-Botet, Miguelen
dc.contributor.authorMaier, Andreaen
dc.contributor.authorMcElhaney, Janeten
dc.contributor.authorMoss, Paulen
dc.contributor.authorNaumova, Elissavetaen
dc.contributor.authorNikolich-Zugich, Jankoen
dc.contributor.authorPera, Alejandraen
dc.contributor.authorRector, Jerralden
dc.contributor.authorRiddell, Natalieen
dc.contributor.authorSanchez-Correa, Beatrizen
dc.contributor.authorSansoni, Paoloen
dc.contributor.authorSauce, Delphineen
dc.contributor.authorvan Lier, Reneen
dc.contributor.authorWang, Georgeen
dc.contributor.authorWills, Marken
dc.contributor.authorZielinski, Maciejen
dc.contributor.authorPawelec, Grahamen
dc.date.accessioned2016-05-20T08:59:56Z-
dc.date.available2016-05-20T08:59:56Z-
dc.date.issued2012en
dc.identifier.citationSolana et al. Immunity & Ageing 2012, 9:23 http://www.immunityageing.com/content/9/1/23en
dc.identifier.doi10.1186/1742-4933-9-23en
dc.identifier.urihttp://hdl.handle.net/10150/610158-
dc.description.abstractAlone among herpesviruses, persistent Cytomegalovirus (CMV) markedly alters the numbers and proportions of peripheral immune cells in infected-vs-uninfected people. Because the rate of CMV infection increases with age in most countries, it has been suggested that it drives or at least exacerbates "immunosenescence". This contention remains controversial and was the primary subject of the Third International Workshop on CMV & Immunosenescence which was held in Cordoba, Spain, 15-16th March, 2012. Discussions focused on several main themes including the effects of CMV on adaptive immunity and immunosenescence, characterization of CMV-specific T cells, impact of CMV infection and ageing on innate immunity, and finally, most important, the clinical implications of immunosenescence and CMV infection. Here we summarize the major findings of this workshop.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urlhttp://www.immunityageing.com/content/9/1/23en
dc.rights© 2012 Solana et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0)en
dc.titleCMV and Immunosenescence: from basics to clinicsen
dc.typeArticleen
dc.identifier.eissn1742-4933en
dc.contributor.departmentImmunology Unit, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)-Reina Sofia University Hospital-University of Cordoba, Cordoba, Spainen
dc.contributor.departmentImmunology Unit, Department of Physiology, University of Extremadura, Caceres, Spainen
dc.contributor.departmentUniversity of Michigan, Department of Epidemiology, Center for Social Epidemiology and Population Health, Ann Arbor, Michigan, USAen
dc.contributor.departmentDivision of Infection and Immunity, University College London, London, UKen
dc.contributor.departmentInfections and Immunity, Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, Franceen
dc.contributor.departmentSchool of Cancer Sciences, University of Birmingham, Birmingham, UKen
dc.contributor.departmentUniversity of Amsterdam, Amsterdam, The Netherlandsen
dc.contributor.departmentDepartment of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germanyen
dc.contributor.departmentDepartment of Internal Medicine II, Center for Medical Research, University of Tübingen, Tübingen, Germanyen
dc.contributor.departmentLaboratory of Molecular Immune-Biology, Hospital General Universitario Gregorio Marañón, Madrid and Laboratory of Immunovirology; Infectious Diseases Service, IBiS, Seville, Spainen
dc.contributor.departmentDepartment of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida, USAen
dc.contributor.departmentResearch Center on Aging, Sherbrooke, Canadaen
dc.contributor.departmentRegenerative Medicine Group, Cranfield Health, Cranfield University, Cranfield, UKen
dc.contributor.departmentInstitute for Biomedical Aging Research, University of Innsbruck, Innsbruck, Austriaen
dc.contributor.departmentDepartment of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon, USAen
dc.contributor.departmentUniversity of Tampere, Medical School, Tampere, Finlanden
dc.contributor.departmentBrighton and Sussex Medical School, Brighton, UKen
dc.contributor.departmentSingapore Immunology Network, Singapore, Singaporeen
dc.contributor.departmentIMIM (Hospital del Mar Research Institute), Univ. Pompeu Fabra, Barcelona, Spainen
dc.contributor.departmentDepartment of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlandsen
dc.contributor.departmentUniversity of British Columbia, Vancouver, Canadaen
dc.contributor.departmentDepartment of Clinical Immunology, University Hospital Alexandrovska, Sofia, Bulgariaen
dc.contributor.departmentDepartment of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, Arizona, USAen
dc.contributor.departmentUniversity of Birmingham, Birmingham, UKen
dc.contributor.departmentDepartment of Internal Medicine and Biomedical Sciences, University of Parma, Parma, Italyen
dc.contributor.departmentExperimental Immunology, Academic Medical Center, Amsterdam, The Netherlandsen
dc.contributor.departmentDivision of Geriatric Medicine and Gerontology, Biology of Healthy Aging Program, Johns Hopkins University School of Medicine, Baltimore, Maryland, USAen
dc.contributor.departmentUniversity of Cambridge Department of Medicine Addenbrookes Hospital, Cambridge, UKen
dc.contributor.departmentDepartment of Clinical Immunology and Transplantology, Medical University of Gdansk, Gdansk, Polanden
dc.contributor.departmentMannheim Institute of Public Health, Social and Preventive Medicine (MIPH), University of Heidelberg, Mannheim Medical Faculty, Mannheim, Germanyen
dc.identifier.journalImmunity & Ageingen
dc.description.collectioninformationThis item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen
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