Metabolic reprogramming by viruses in the sunlit and dark ocean

Persistent Link:
http://hdl.handle.net/10150/610152
Title:
Metabolic reprogramming by viruses in the sunlit and dark ocean
Author:
Hurwitz, Bonnie; Hallam, Steven; Sullivan, Matthew
Affiliation:
Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Graduate Program in Bioinformatics, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Current address: Office of the Senior Vice President of Health Sciences, University of Arizona, Tucson, AZ 85724, USA
Issue Date:
2013
Publisher:
BioMed Central
Citation:
Hurwitz et al. Genome Biology 2013, 14:R123 http://genomebiology.com/2013/14/11/R123
Journal:
Genome Biology
Rights:
© 2013 Hurwitz et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0)
Collection Information:
This item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.
Abstract:
BACKGROUND:Marine ecosystem function is largely determined by matter and energy transformations mediated by microbial community interaction networks. Viral infection modulates network properties through mortality, gene transfer and metabolic reprogramming.RESULTS:Here we explore the nature and extent of viral metabolic reprogramming throughout the Pacific Ocean depth continuum. We describe 35 marine viral gene families with potential to reprogram metabolic flux through central metabolic pathways recovered from Pacific Ocean waters. Four of these families have been previously reported but 31 are novel. These known and new carbon pathway auxiliary metabolic genes were recovered from a total of 22 viral metagenomes in which viral auxiliary metabolic genes were differentiated from low-level cellular DNA inputs based on small subunit ribosomal RNA gene content, taxonomy, fragment recruitment and genomic context information. Auxiliary metabolic gene distribution patterns reveal that marine viruses target overlapping, but relatively distinct pathways in sunlit and dark ocean waters to redirect host carbon flux towards energy production and viral genome replication under low nutrient, niche-differentiated conditions throughout the depth continuum.CONCLUSIONS:Given half of ocean microbes are infected by viruses at any given time, these findings of broad viral metabolic reprogramming suggest the need for renewed consideration of viruses in global ocean carbon models.
DOI:
10.1186/gb-2013-14-11-r123
Version:
Final published version
Additional Links:
http://genomebiology.com/2013/14/11/R123

Full metadata record

DC FieldValue Language
dc.contributor.authorHurwitz, Bonnieen
dc.contributor.authorHallam, Stevenen
dc.contributor.authorSullivan, Matthewen
dc.date.accessioned2016-05-20T08:59:45Z-
dc.date.available2016-05-20T08:59:45Z-
dc.date.issued2013en
dc.identifier.citationHurwitz et al. Genome Biology 2013, 14:R123 http://genomebiology.com/2013/14/11/R123en
dc.identifier.doi10.1186/gb-2013-14-11-r123en
dc.identifier.urihttp://hdl.handle.net/10150/610152-
dc.description.abstractBACKGROUND:Marine ecosystem function is largely determined by matter and energy transformations mediated by microbial community interaction networks. Viral infection modulates network properties through mortality, gene transfer and metabolic reprogramming.RESULTS:Here we explore the nature and extent of viral metabolic reprogramming throughout the Pacific Ocean depth continuum. We describe 35 marine viral gene families with potential to reprogram metabolic flux through central metabolic pathways recovered from Pacific Ocean waters. Four of these families have been previously reported but 31 are novel. These known and new carbon pathway auxiliary metabolic genes were recovered from a total of 22 viral metagenomes in which viral auxiliary metabolic genes were differentiated from low-level cellular DNA inputs based on small subunit ribosomal RNA gene content, taxonomy, fragment recruitment and genomic context information. Auxiliary metabolic gene distribution patterns reveal that marine viruses target overlapping, but relatively distinct pathways in sunlit and dark ocean waters to redirect host carbon flux towards energy production and viral genome replication under low nutrient, niche-differentiated conditions throughout the depth continuum.CONCLUSIONS:Given half of ocean microbes are infected by viruses at any given time, these findings of broad viral metabolic reprogramming suggest the need for renewed consideration of viruses in global ocean carbon models.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urlhttp://genomebiology.com/2013/14/11/R123en
dc.rights© 2013 Hurwitz et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0)en
dc.titleMetabolic reprogramming by viruses in the sunlit and dark oceanen
dc.typeArticleen
dc.contributor.departmentEcology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USAen
dc.contributor.departmentDepartment of Microbiology and Immunology, University of British Columbia, Vancouver, BC V6T 1Z4, Canadaen
dc.contributor.departmentGraduate Program in Bioinformatics, University of British Columbia, Vancouver, BC V6T 1Z4, Canadaen
dc.contributor.departmentCurrent address: Office of the Senior Vice President of Health Sciences, University of Arizona, Tucson, AZ 85724, USAen
dc.identifier.journalGenome Biologyen
dc.description.collectioninformationThis item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen
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