Neuroblastoma of the elderly, an oncologist's nightmare: case presentation, literature review and SEER database analysis

Persistent Link:
http://hdl.handle.net/10150/610137
Title:
Neuroblastoma of the elderly, an oncologist's nightmare: case presentation, literature review and SEER database analysis
Author:
Rogowitz, Elisa; Babiker, Hani; Kanaan, Mohammed; Millius, Rebecca; Ringenberg, Q.; Bishop, Maria
Affiliation:
University of Arizona College of Medicine, 1501 N. Campbell Ave, Tucson, AZ 85724, USA; Division of Hematology-Oncology, Department of Medicine, Southern Arizona VA Health Care System, 3601 S 6Th Ave, Tucson, AZ 85723, USA; Division of Hematology-Oncology, Department of Medicine, University of Arizona College of Medicine, 1501 North Campbell Avenue, Tucson, AZ 85724, USA; Division of Hematology-Oncology, Department of Medicine, University of Arizona Cancer Center, 1515 N Campbell Ave, Tucson, AZ 85724, USA; Department of Pathology, University of Arizona College of Medicine, 1501 North Campbell Avenue, Tucson, AZ 85724, USA
Issue Date:
2014
Publisher:
BioMed Central
Citation:
Rogowitz et al. Experimental Hematology & Oncology 2014, 3:20 http://www.ehoonline.org/content/3/1/20
Journal:
Experimental Hematology & Oncology
Rights:
© 2014 Rogowitz et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0)
Collection Information:
This item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.
Abstract:
Neuroblastoma is considered a pediatric malignancy as over 95% of cases are diagnosed in patients less than or equal to 10years old. This cancer is extremely rare in elderly patients. We conducted a Surveillance, Epidemiology, and End Results (SEER) database analysis in the USA between 1973-2007 that revealed only 35 elderly patients (>60years of age) with neuroblastoma of whom only 2 patients had primary mediastinal neuroblastoma. There is a paucity of treatment and survival outcomes data for the elderly owing to the rarity of neuroblastoma in this population. Currently there are no standard guidelines or protocols for treatment of adult neuroblastoma. We report a rare and challenging case of an 86-year old patient presenting with mediastinal neuroblastoma and syndrome of inappropriate antidiuretic hormone secretion (SIADH) successfully treated with resection. Herein, we also provide a review of the literature and updated survival data on neuroblastoma based on results of our SEER database review.
EISSN:
2162-3619
DOI:
10.1186/2162-3619-3-20
Keywords:
Thymus; Neuroblastoma; Adult; SIADH
Version:
Final published version
Additional Links:
http://www.ehoonline.org/content/3/1/20

Full metadata record

DC FieldValue Language
dc.contributor.authorRogowitz, Elisaen
dc.contributor.authorBabiker, Hanien
dc.contributor.authorKanaan, Mohammeden
dc.contributor.authorMillius, Rebeccaen
dc.contributor.authorRingenberg, Q.en
dc.contributor.authorBishop, Mariaen
dc.date.accessioned2016-05-20T08:59:23Z-
dc.date.available2016-05-20T08:59:23Z-
dc.date.issued2014en
dc.identifier.citationRogowitz et al. Experimental Hematology & Oncology 2014, 3:20 http://www.ehoonline.org/content/3/1/20en
dc.identifier.doi10.1186/2162-3619-3-20en
dc.identifier.urihttp://hdl.handle.net/10150/610137-
dc.description.abstractNeuroblastoma is considered a pediatric malignancy as over 95% of cases are diagnosed in patients less than or equal to 10years old. This cancer is extremely rare in elderly patients. We conducted a Surveillance, Epidemiology, and End Results (SEER) database analysis in the USA between 1973-2007 that revealed only 35 elderly patients (>60years of age) with neuroblastoma of whom only 2 patients had primary mediastinal neuroblastoma. There is a paucity of treatment and survival outcomes data for the elderly owing to the rarity of neuroblastoma in this population. Currently there are no standard guidelines or protocols for treatment of adult neuroblastoma. We report a rare and challenging case of an 86-year old patient presenting with mediastinal neuroblastoma and syndrome of inappropriate antidiuretic hormone secretion (SIADH) successfully treated with resection. Herein, we also provide a review of the literature and updated survival data on neuroblastoma based on results of our SEER database review.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urlhttp://www.ehoonline.org/content/3/1/20en
dc.rights© 2014 Rogowitz et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0)en
dc.subjectThymusen
dc.subjectNeuroblastomaen
dc.subjectAdulten
dc.subjectSIADHen
dc.titleNeuroblastoma of the elderly, an oncologist's nightmare: case presentation, literature review and SEER database analysisen
dc.typeArticleen
dc.identifier.eissn2162-3619en
dc.contributor.departmentUniversity of Arizona College of Medicine, 1501 N. Campbell Ave, Tucson, AZ 85724, USAen
dc.contributor.departmentDivision of Hematology-Oncology, Department of Medicine, Southern Arizona VA Health Care System, 3601 S 6Th Ave, Tucson, AZ 85723, USAen
dc.contributor.departmentDivision of Hematology-Oncology, Department of Medicine, University of Arizona College of Medicine, 1501 North Campbell Avenue, Tucson, AZ 85724, USAen
dc.contributor.departmentDivision of Hematology-Oncology, Department of Medicine, University of Arizona Cancer Center, 1515 N Campbell Ave, Tucson, AZ 85724, USAen
dc.contributor.departmentDepartment of Pathology, University of Arizona College of Medicine, 1501 North Campbell Avenue, Tucson, AZ 85724, USAen
dc.identifier.journalExperimental Hematology & Oncologyen
dc.description.collectioninformationThis item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen
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