Macrophage migration inhibitory factor: controller of systemic inflammation

Persistent Link:
http://hdl.handle.net/10150/610128
Title:
Macrophage migration inhibitory factor: controller of systemic inflammation
Author:
Larson, Douglas; Horak, Katherine
Affiliation:
Sarver Heart Center and Departments of Surgery and Medical Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, USA
Issue Date:
2006
Publisher:
BioMed Central
Citation:
Critical Care 2006, 10:138 (doi:10.1186/cc4899)
Journal:
Critical Care
Rights:
© 2006 BioMed Central Ltd
Collection Information:
This item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.
Abstract:
Macrophage migration inhibitory factor (MIF) is a cytokine that is secreted by the anterior pituitary and immune cells in response to surgical stress, injury, and sepsis. This cytokine appears to be a critical regulator of the inflammatory pathways, leading to systemic inflammatory response syndrome and subsequent multiple organ dysfunction syndrome. This report provides an integrated scheme describing the manner by which MIF controls the neurohormonal response and the adaptive immune system, namely the T-helper (Th)1 and Th2 lymphocytes, which results in the release of pro-inflammatory cytokines and the anti-inflammatory cytokine interleukin-10. The development of systemic inflammatory response syndrome and subsequent development of multiple organ dysfunction syndrome appear to be related to MIF levels and the balance of Th1 and Th2 function.
EISSN:
1466-609X
DOI:
10.1186/cc4899
Version:
Final published version
Additional Links:
http://ccforum.com/content/10/2/138

Full metadata record

DC FieldValue Language
dc.contributor.authorLarson, Douglasen
dc.contributor.authorHorak, Katherineen
dc.date.accessioned2016-05-20T08:59:12Z-
dc.date.available2016-05-20T08:59:12Z-
dc.date.issued2006en
dc.identifier.citationCritical Care 2006, 10:138 (doi:10.1186/cc4899)en
dc.identifier.doi10.1186/cc4899en
dc.identifier.urihttp://hdl.handle.net/10150/610128-
dc.description.abstractMacrophage migration inhibitory factor (MIF) is a cytokine that is secreted by the anterior pituitary and immune cells in response to surgical stress, injury, and sepsis. This cytokine appears to be a critical regulator of the inflammatory pathways, leading to systemic inflammatory response syndrome and subsequent multiple organ dysfunction syndrome. This report provides an integrated scheme describing the manner by which MIF controls the neurohormonal response and the adaptive immune system, namely the T-helper (Th)1 and Th2 lymphocytes, which results in the release of pro-inflammatory cytokines and the anti-inflammatory cytokine interleukin-10. The development of systemic inflammatory response syndrome and subsequent development of multiple organ dysfunction syndrome appear to be related to MIF levels and the balance of Th1 and Th2 function.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urlhttp://ccforum.com/content/10/2/138en
dc.rights© 2006 BioMed Central Ltden
dc.titleMacrophage migration inhibitory factor: controller of systemic inflammationen
dc.typeArticleen
dc.identifier.eissn1466-609Xen
dc.contributor.departmentSarver Heart Center and Departments of Surgery and Medical Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, USAen
dc.identifier.journalCritical Careen
dc.description.collectioninformationThis item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen
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