Influence of twenty-five per cent human serum albumin on total and ionized calcium concentrations in vivo

Persistent Link:
http://hdl.handle.net/10150/610126
Title:
Influence of twenty-five per cent human serum albumin on total and ionized calcium concentrations in vivo
Author:
Erstad, Brian L.; Richards, Hal; Rose, Susan; Nakazato, Paul; Fortune, John
Affiliation:
Arizona Health Sciences Center, Departments of Pharmacy Practice and Science and Surgery, Tucson, Arizona, USA
Issue Date:
1999
Publisher:
BioMed Central
Citation:
Crit Care 1999, 3:117–121 http://ccforum.com/content/3/4/117
Journal:
Critical Care
Rights:
© Current Science Ltd
Collection Information:
This item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.
Abstract:
BACKGROUND:A inverse correlation has been found between changes in ionized calcium concentrations and the addition of albumin in vitro, which may explain adverse cardiovascular effects attributed to exogenous albumin in vivo. The purpose of this investigation was to determine the interaction (if any) between exogenous 25% albumin administration (100 ml given over < 30 min) and calcium concentrations in patients, all but one of whom were in an intensive care unit.RESULTS:There were no significant differences in the ionized calcium concentrations obtained before, at the end and 6 h after the administration of albumin (1.09 +/- 0.23, 1.06 +/- 0.22, 1.06 +/- 0.21 mmol/l, respectively). Similarly, there were no significant differences in the total calcium concentrations between these same time periods (2.03 +/- 0.18, 2.05 +/- 0.20, 2.08 +/- 0.23 mmol/l, respectively).CONCLUSIONS:In patients receiving infusions of 25% albumin, it appears that circulating calcium concentrations are well regulated by homeostatic mechanisms. Albumin infusions had no effect on calcium concentrations, although it is possible that temporary changes of questionable clinical importance may have occurred between measurement periods.
EISSN:
1466-609X
DOI:
10.1186/cc353
Keywords:
albumin; albumin administration; calcium concentrations; adverse effects
Version:
Final published version
Additional Links:
http://ccforum.com/content/3/4/117

Full metadata record

DC FieldValue Language
dc.contributor.authorErstad, Brian L.en
dc.contributor.authorRichards, Halen
dc.contributor.authorRose, Susanen
dc.contributor.authorNakazato, Paulen
dc.contributor.authorFortune, Johnen
dc.date.accessioned2016-05-20T08:59:09Z-
dc.date.available2016-05-20T08:59:09Z-
dc.date.issued1999en
dc.identifier.citationCrit Care 1999, 3:117–121 http://ccforum.com/content/3/4/117en
dc.identifier.doi10.1186/cc353en
dc.identifier.urihttp://hdl.handle.net/10150/610126-
dc.description.abstractBACKGROUND:A inverse correlation has been found between changes in ionized calcium concentrations and the addition of albumin in vitro, which may explain adverse cardiovascular effects attributed to exogenous albumin in vivo. The purpose of this investigation was to determine the interaction (if any) between exogenous 25% albumin administration (100 ml given over < 30 min) and calcium concentrations in patients, all but one of whom were in an intensive care unit.RESULTS:There were no significant differences in the ionized calcium concentrations obtained before, at the end and 6 h after the administration of albumin (1.09 +/- 0.23, 1.06 +/- 0.22, 1.06 +/- 0.21 mmol/l, respectively). Similarly, there were no significant differences in the total calcium concentrations between these same time periods (2.03 +/- 0.18, 2.05 +/- 0.20, 2.08 +/- 0.23 mmol/l, respectively).CONCLUSIONS:In patients receiving infusions of 25% albumin, it appears that circulating calcium concentrations are well regulated by homeostatic mechanisms. Albumin infusions had no effect on calcium concentrations, although it is possible that temporary changes of questionable clinical importance may have occurred between measurement periods.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urlhttp://ccforum.com/content/3/4/117en
dc.rights© Current Science Ltden
dc.subjectalbuminen
dc.subjectalbumin administrationen
dc.subjectcalcium concentrationsen
dc.subjectadverse effectsen
dc.titleInfluence of twenty-five per cent human serum albumin on total and ionized calcium concentrations in vivoen
dc.typeArticleen
dc.identifier.eissn1466-609Xen
dc.contributor.departmentArizona Health Sciences Center, Departments of Pharmacy Practice and Science and Surgery, Tucson, Arizona, USAen
dc.identifier.journalCritical Careen
dc.description.collectioninformationThis item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen
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