Impact of urinary incontinence on health-related quality of life, daily activities, and healthcare resource utilization in patients with neurogenic detrusor overactivity

Persistent Link:
http://hdl.handle.net/10150/610068
Title:
Impact of urinary incontinence on health-related quality of life, daily activities, and healthcare resource utilization in patients with neurogenic detrusor overactivity
Author:
Tang, Derek; Colayco, Danielle; Piercy, James; Patel, Vaishali; Globe, Denise; Chancellor, Michael
Affiliation:
The University of Arizona College of Pharmacy, 1295 N. Martin, PO Box 210202, Tucson, AZ 85721, USA; Department of Global Health Outcomes Strategy and Research, Allergan Inc, 2525 Dupont Drive, Irvine, CA 92612, USA; Adelphi Real World, Adelphi Mill, Grimshaw Lane, Bollington SK10 5JB, UK; Oakland University William Beaumont School of Medicine, Neurourology Program, Beaumont Hospital, 3535 West 13 Mile Road, Royal Oak, MI 48073, USA
Issue Date:
2014
Publisher:
BioMed Central
Citation:
Tang et al. BMC Neurology 2014, 14:74 http://www.biomedcentral.com/1471-2377/14/74
Journal:
BMC Neurology
Rights:
© 2014 Tang et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0)
Collection Information:
This item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.
Abstract:
BACKGROUND:Neurogenic detrusor overactivity (NDO) leads to impaired health-related quality of life (HRQoL), productivity, and greater healthcare resource burden. The humanistic and economic burden may be more apparent in NDO patients with urinary incontinence (UI). The objective of this study was to compare the HRQoL, productivity, and health resource use (HRU) between continent and incontinent NDO patients.METHODS:A retrospective database analysis was conducted using the Adelphi Overactive Bladder (OAB)/UI Disease Specific Programme, a multi-national, cross-sectional survey reported from both patients' and physicians' perspectives. The population for this analysis included NDO patients with or without UI. General and disease-specific HRQoL were assessed using the EuroQoL-5D (EQ-5D), Incontinence Quality of Life questionnaire (I-QOL), and the Overactive Bladder Questionnaire (OAB-q). Productivity and daily activity impairment were measured using the Work Productivity and Activity Impairment (WPAI) questionnaire. HRU indicators included OAB-related surgery, OAB-related hospitalizations, incontinence pad usage, switching anticholinergics used for OAB due to inadequate response or adverse effects, and OAB-related physician visits. Bivariate analyses, multivariate ordinary least squares (OLS) regression analyses and published minimal clinically important differences (MCID) were used to assess relationships between incontinent status and the aforementioned outcome measures.RESULTS:A total of 324 NDO patients with or without urinary incontinence were included, averaging 54years of age (SD 16), of whom 43.8 percent were male. Bivariate analyses detected no significant relationship between incontinent status and HRU variables. Regression analyses revealed that incontinent patients had clinically and statistically lower disease-specific HRQoL and greater impairment in daily activities as compared to continent patients. On average, incontinent patients scored 10 points lower on the I-QOL total score, 9 points lower on the OAB-q HRQoL score, 15 points higher on OAB-q symptom severity, and experienced 8.2 percent higher activity impairment due to their bladder condition (all p <0.001).CONCLUSIONS:Incontinent NDO patients experience significantly lower HRQoL and activity impairment as compared to continent NDO patients.
EISSN:
1471-2377
DOI:
10.1186/1471-2377-14-74
Keywords:
Neurogenic detrusor overactivity; Incontinence; Burden of illness; Quality of life; Productivity
Version:
Final published version
Additional Links:
http://www.biomedcentral.com/1471-2377/14/74

Full metadata record

DC FieldValue Language
dc.contributor.authorTang, Dereken
dc.contributor.authorColayco, Danielleen
dc.contributor.authorPiercy, Jamesen
dc.contributor.authorPatel, Vaishalien
dc.contributor.authorGlobe, Deniseen
dc.contributor.authorChancellor, Michaelen
dc.date.accessioned2016-05-20T08:57:50Z-
dc.date.available2016-05-20T08:57:50Z-
dc.date.issued2014en
dc.identifier.citationTang et al. BMC Neurology 2014, 14:74 http://www.biomedcentral.com/1471-2377/14/74en
dc.identifier.doi10.1186/1471-2377-14-74en
dc.identifier.urihttp://hdl.handle.net/10150/610068-
dc.description.abstractBACKGROUND:Neurogenic detrusor overactivity (NDO) leads to impaired health-related quality of life (HRQoL), productivity, and greater healthcare resource burden. The humanistic and economic burden may be more apparent in NDO patients with urinary incontinence (UI). The objective of this study was to compare the HRQoL, productivity, and health resource use (HRU) between continent and incontinent NDO patients.METHODS:A retrospective database analysis was conducted using the Adelphi Overactive Bladder (OAB)/UI Disease Specific Programme, a multi-national, cross-sectional survey reported from both patients' and physicians' perspectives. The population for this analysis included NDO patients with or without UI. General and disease-specific HRQoL were assessed using the EuroQoL-5D (EQ-5D), Incontinence Quality of Life questionnaire (I-QOL), and the Overactive Bladder Questionnaire (OAB-q). Productivity and daily activity impairment were measured using the Work Productivity and Activity Impairment (WPAI) questionnaire. HRU indicators included OAB-related surgery, OAB-related hospitalizations, incontinence pad usage, switching anticholinergics used for OAB due to inadequate response or adverse effects, and OAB-related physician visits. Bivariate analyses, multivariate ordinary least squares (OLS) regression analyses and published minimal clinically important differences (MCID) were used to assess relationships between incontinent status and the aforementioned outcome measures.RESULTS:A total of 324 NDO patients with or without urinary incontinence were included, averaging 54years of age (SD 16), of whom 43.8 percent were male. Bivariate analyses detected no significant relationship between incontinent status and HRU variables. Regression analyses revealed that incontinent patients had clinically and statistically lower disease-specific HRQoL and greater impairment in daily activities as compared to continent patients. On average, incontinent patients scored 10 points lower on the I-QOL total score, 9 points lower on the OAB-q HRQoL score, 15 points higher on OAB-q symptom severity, and experienced 8.2 percent higher activity impairment due to their bladder condition (all p <0.001).CONCLUSIONS:Incontinent NDO patients experience significantly lower HRQoL and activity impairment as compared to continent NDO patients.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urlhttp://www.biomedcentral.com/1471-2377/14/74en
dc.rights© 2014 Tang et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0)en
dc.subjectNeurogenic detrusor overactivityen
dc.subjectIncontinenceen
dc.subjectBurden of illnessen
dc.subjectQuality of lifeen
dc.subjectProductivityen
dc.titleImpact of urinary incontinence on health-related quality of life, daily activities, and healthcare resource utilization in patients with neurogenic detrusor overactivityen
dc.typeArticleen
dc.identifier.eissn1471-2377en
dc.contributor.departmentThe University of Arizona College of Pharmacy, 1295 N. Martin, PO Box 210202, Tucson, AZ 85721, USAen
dc.contributor.departmentDepartment of Global Health Outcomes Strategy and Research, Allergan Inc, 2525 Dupont Drive, Irvine, CA 92612, USAen
dc.contributor.departmentAdelphi Real World, Adelphi Mill, Grimshaw Lane, Bollington SK10 5JB, UKen
dc.contributor.departmentOakland University William Beaumont School of Medicine, Neurourology Program, Beaumont Hospital, 3535 West 13 Mile Road, Royal Oak, MI 48073, USAen
dc.identifier.journalBMC Neurologyen
dc.description.collectioninformationThis item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen
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