Dominance of multidrug resistant CC271 clones in macrolide-resistant Streptococcus pneumoniae in Arizona

Persistent Link:
http://hdl.handle.net/10150/610057
Title:
Dominance of multidrug resistant CC271 clones in macrolide-resistant Streptococcus pneumoniae in Arizona
Author:
Bowers, Jolene; Driebe, Elizabeth; Nibecker, Jennifer; Wojack, Bette; Sarovich, Derek; Wong, Ada; Brzoska, Pius; Hubert, Nathaniel; Knadler, Andrew; Watson, Lindsey; Wagner, David; Furtado, Manohar; Saubolle, Michael; Engelthaler, David; Keim, Paul
Affiliation:
Translational Genomics Research Institute, Flagstaff, AZ, USA; Laboratory Sciences of Arizona, Tempe, AZ, USA; Northern Arizona University, Flagstaff, AZ, USA; Life Technologies, Foster City, CA, USA; University of Arizona, Tucson, AZ, USA
Issue Date:
2012
Publisher:
BioMed Central
Citation:
Bowers et al. BMC Microbiology 2012, 12:12 http://www.biomedcentral.com/1471-2180/12/12
Journal:
BMC Microbiology
Rights:
© 2012 Bowers et al; BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0)
Collection Information:
This item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.
Abstract:
BACKGROUND:Rates of resistance to macrolide antibiotics in Streptococcus pneumoniae are rising around the world due to the spread of mobile genetic elements harboring mef(E) and erm(B) genes and post-vaccine clonal expansion of strains that carry them.RESULTS:Characterization of 592 clinical isolates collected in Arizona over a 10 year period shows 23.6% are macrolide resistant. The largest portion of the macrolide-resistant population, 52%, is dual mef(E)/erm(B)-positive. All dual-positive isolates are multidrug-resistant clonal lineages of Taiwan19F-14, mostly multilocus sequence type 320, carrying the recently described transposon Tn2010. The remainder of the macrolide resistant S. pneumoniae collection includes 31% mef(E)-positive, and 9% erm(B)-positive strains.CONCLUSIONS:The dual-positive, multidrug-resistant S. pneumoniae clones have likely expanded by switching to non-vaccine serotypes after the heptavalent pneumococcal conjugate vaccine release, and their success limits therapy options. This upsurge could have a considerable clinical impact in Arizona.
EISSN:
1471-2180
DOI:
10.1186/1471-2180-12-12
Version:
Final published version
Additional Links:
http://www.biomedcentral.com/1471-2180/12/12

Full metadata record

DC FieldValue Language
dc.contributor.authorBowers, Joleneen
dc.contributor.authorDriebe, Elizabethen
dc.contributor.authorNibecker, Jenniferen
dc.contributor.authorWojack, Betteen
dc.contributor.authorSarovich, Dereken
dc.contributor.authorWong, Adaen
dc.contributor.authorBrzoska, Piusen
dc.contributor.authorHubert, Nathanielen
dc.contributor.authorKnadler, Andrewen
dc.contributor.authorWatson, Lindseyen
dc.contributor.authorWagner, Daviden
dc.contributor.authorFurtado, Manoharen
dc.contributor.authorSaubolle, Michaelen
dc.contributor.authorEngelthaler, Daviden
dc.contributor.authorKeim, Paulen
dc.date.accessioned2016-05-20T08:57:34Z-
dc.date.available2016-05-20T08:57:34Z-
dc.date.issued2012en
dc.identifier.citationBowers et al. BMC Microbiology 2012, 12:12 http://www.biomedcentral.com/1471-2180/12/12en
dc.identifier.doi10.1186/1471-2180-12-12en
dc.identifier.urihttp://hdl.handle.net/10150/610057-
dc.description.abstractBACKGROUND:Rates of resistance to macrolide antibiotics in Streptococcus pneumoniae are rising around the world due to the spread of mobile genetic elements harboring mef(E) and erm(B) genes and post-vaccine clonal expansion of strains that carry them.RESULTS:Characterization of 592 clinical isolates collected in Arizona over a 10 year period shows 23.6% are macrolide resistant. The largest portion of the macrolide-resistant population, 52%, is dual mef(E)/erm(B)-positive. All dual-positive isolates are multidrug-resistant clonal lineages of Taiwan19F-14, mostly multilocus sequence type 320, carrying the recently described transposon Tn2010. The remainder of the macrolide resistant S. pneumoniae collection includes 31% mef(E)-positive, and 9% erm(B)-positive strains.CONCLUSIONS:The dual-positive, multidrug-resistant S. pneumoniae clones have likely expanded by switching to non-vaccine serotypes after the heptavalent pneumococcal conjugate vaccine release, and their success limits therapy options. This upsurge could have a considerable clinical impact in Arizona.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urlhttp://www.biomedcentral.com/1471-2180/12/12en
dc.rights© 2012 Bowers et al; BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0)en
dc.titleDominance of multidrug resistant CC271 clones in macrolide-resistant Streptococcus pneumoniae in Arizonaen
dc.typeArticleen
dc.identifier.eissn1471-2180en
dc.contributor.departmentTranslational Genomics Research Institute, Flagstaff, AZ, USAen
dc.contributor.departmentLaboratory Sciences of Arizona, Tempe, AZ, USAen
dc.contributor.departmentNorthern Arizona University, Flagstaff, AZ, USAen
dc.contributor.departmentLife Technologies, Foster City, CA, USAen
dc.contributor.departmentUniversity of Arizona, Tucson, AZ, USAen
dc.identifier.journalBMC Microbiologyen
dc.description.collectioninformationThis item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen
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