Midazolam, hippocampal function, and transitive inference: Reply to Greene

Persistent Link:
http://hdl.handle.net/10150/610021
Title:
Midazolam, hippocampal function, and transitive inference: Reply to Greene
Author:
Frank, Michael; O'Reilly, Randall; Curran, Tim
Affiliation:
Dept of Psychology and Program in Neuroscience, University of Arizona, Tucson, USA; Dept of Psychology and Center for Neuroscience, University of Colorado at Boulder. Boulder, USA
Issue Date:
2008
Publisher:
BioMed Central
Citation:
Behavioral and Brain Functions 2008, 4:5 doi:10.1186/1744-9081-4-5
Journal:
Behavioral and Brain Functions
Rights:
© 2008 Frank et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0)
Collection Information:
This item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.
Abstract:
The transitive inference (TI) task assesses the ability to generalize learned knowledge to new contexts, and is thought to depend on the hippocampus (Dusek & Eichenbaum, 1997). Animals or humans learn in separate trials to choose stimulus A over B, B over C, C over D and D over E, via reinforcement feedback. Transitive responding based on the hierarchical structure A > B > C > D > E is then tested with the novel BD pair. We and others have argued that successful BD performance by animals - and even humans in some implicit studies - can be explained by simple reinforcement learning processes which do not depend critically on the hippocampus, but rather on the striatal dopamine system. We recently showed that the benzodiazepene midazolam, which is thought to disrupt hippocampal function, profoundly impaired human memory recall performance but actually enhanced implicit TI performance (Frank, O'Reilly & Curran, 2006). We posited that midazolam biased participants to recruit striatum during learning due to dysfunctional hippocampal processing, and that this change actually supported generalization of reinforcement values. Greene (2007) questions the validity of our pharmacological assumptions and argues that our conclusions are unfounded. Here we stand by our original hypothesis, which remains the most parsimonious account of the data, and is grounded by multiple lines of evidence.
EISSN:
1744-9081
DOI:
10.1186/1744-9081-4-5
Version:
Final published version
Additional Links:
http://www.behavioralandbrainfunctions.com/content/4/1/5

Full metadata record

DC FieldValue Language
dc.contributor.authorFrank, Michaelen
dc.contributor.authorO'Reilly, Randallen
dc.contributor.authorCurran, Timen
dc.date.accessioned2016-05-20T08:56:41Z-
dc.date.available2016-05-20T08:56:41Z-
dc.date.issued2008en
dc.identifier.citationBehavioral and Brain Functions 2008, 4:5 doi:10.1186/1744-9081-4-5en
dc.identifier.doi10.1186/1744-9081-4-5en
dc.identifier.urihttp://hdl.handle.net/10150/610021-
dc.description.abstractThe transitive inference (TI) task assesses the ability to generalize learned knowledge to new contexts, and is thought to depend on the hippocampus (Dusek & Eichenbaum, 1997). Animals or humans learn in separate trials to choose stimulus A over B, B over C, C over D and D over E, via reinforcement feedback. Transitive responding based on the hierarchical structure A > B > C > D > E is then tested with the novel BD pair. We and others have argued that successful BD performance by animals - and even humans in some implicit studies - can be explained by simple reinforcement learning processes which do not depend critically on the hippocampus, but rather on the striatal dopamine system. We recently showed that the benzodiazepene midazolam, which is thought to disrupt hippocampal function, profoundly impaired human memory recall performance but actually enhanced implicit TI performance (Frank, O'Reilly & Curran, 2006). We posited that midazolam biased participants to recruit striatum during learning due to dysfunctional hippocampal processing, and that this change actually supported generalization of reinforcement values. Greene (2007) questions the validity of our pharmacological assumptions and argues that our conclusions are unfounded. Here we stand by our original hypothesis, which remains the most parsimonious account of the data, and is grounded by multiple lines of evidence.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urlhttp://www.behavioralandbrainfunctions.com/content/4/1/5en
dc.rights© 2008 Frank et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0)en
dc.titleMidazolam, hippocampal function, and transitive inference: Reply to Greeneen
dc.typeArticleen
dc.identifier.eissn1744-9081en
dc.contributor.departmentDept of Psychology and Program in Neuroscience, University of Arizona, Tucson, USAen
dc.contributor.departmentDept of Psychology and Center for Neuroscience, University of Colorado at Boulder. Boulder, USAen
dc.identifier.journalBehavioral and Brain Functionsen
dc.description.collectioninformationThis item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen
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