Early Retinal Neuronal Dysfunction in Diabetic Mice: Reduced Light-Evoked Inhibition Increases Rod Pathway Signaling.

Persistent Link:
http://hdl.handle.net/10150/604678
Title:
Early Retinal Neuronal Dysfunction in Diabetic Mice: Reduced Light-Evoked Inhibition Increases Rod Pathway Signaling.
Author:
Moore-Dotson, Johnnie M.; Beckman, Jamie J.; Mazade, Reece E.; Hoon, Mrinalini; Bernstein, Adam S.; Romero-Aleshire, Melissa J.; Brooks, Heddwen L.; Eggers, Erika D.
Affiliation:
Department of Physiology, University of Arizona; Graduate Interdisciplinary Program in Physiological Sciences, University of Arizona; Department of Biomedical Engineering, University of Arizona
Issue Date:
2016-03-01
Publisher:
Association for Research in Vision and Ophthalmology (ARVO)
Citation:
Early Retinal Neuronal Dysfunction in Diabetic Mice: Reduced Light-Evoked Inhibition Increases Rod Pathway Signaling. 2016, 57 (3):1418-30 Invest. Ophthalmol. Vis. Sci.
Journal:
Investigative ophthalmology & visual science
Rights:
Archived with thanks to Investigative ophthalmology & visual science
Abstract:
Recent studies suggest that the neural retinal response to light is compromised in diabetes. Electroretinogram studies suggest that the dim light retinal rod pathway is especially susceptible to diabetic damage. The purpose of this study was to determine whether diabetes alters rod pathway signaling.
ISSN:
1552-5783
PubMed ID:
27028063
DOI:
10.1167/iovs.15-17999
Keywords:
diabetes; GABA; bipolar cells; inhibition; amacrine cells
Additional Links:
http://iovs.arvojournals.org/article.aspx?articleid=2511068

Full metadata record

DC FieldValue Language
dc.contributor.authorMoore-Dotson, Johnnie M.en
dc.contributor.authorBeckman, Jamie J.en
dc.contributor.authorMazade, Reece E.en
dc.contributor.authorHoon, Mrinalinien
dc.contributor.authorBernstein, Adam S.en
dc.contributor.authorRomero-Aleshire, Melissa J.en
dc.contributor.authorBrooks, Heddwen L.en
dc.contributor.authorEggers, Erika D.en
dc.date.accessioned2016-04-06T21:34:23Zen
dc.date.available2016-04-06T21:34:23Zen
dc.date.issued2016-03-01en
dc.identifier.citationEarly Retinal Neuronal Dysfunction in Diabetic Mice: Reduced Light-Evoked Inhibition Increases Rod Pathway Signaling. 2016, 57 (3):1418-30 Invest. Ophthalmol. Vis. Sci.en
dc.identifier.issn1552-5783en
dc.identifier.pmid27028063en
dc.identifier.doi10.1167/iovs.15-17999en
dc.identifier.urihttp://hdl.handle.net/10150/604678en
dc.description.abstractRecent studies suggest that the neural retinal response to light is compromised in diabetes. Electroretinogram studies suggest that the dim light retinal rod pathway is especially susceptible to diabetic damage. The purpose of this study was to determine whether diabetes alters rod pathway signaling.en
dc.language.isoenen
dc.publisherAssociation for Research in Vision and Ophthalmology (ARVO)en
dc.relation.urlhttp://iovs.arvojournals.org/article.aspx?articleid=2511068en
dc.rightsArchived with thanks to Investigative ophthalmology & visual scienceen
dc.subjectdiabetesen
dc.subjectGABAen
dc.subjectbipolar cellsen
dc.subjectinhibitionen
dc.subjectamacrine cellsen
dc.titleEarly Retinal Neuronal Dysfunction in Diabetic Mice: Reduced Light-Evoked Inhibition Increases Rod Pathway Signaling.en
dc.typeArticleen
dc.contributor.departmentDepartment of Physiology, University of Arizonaen
dc.contributor.departmentGraduate Interdisciplinary Program in Physiological Sciences, University of Arizonaen
dc.contributor.departmentDepartment of Biomedical Engineering, University of Arizonaen
dc.identifier.journalInvestigative ophthalmology & visual scienceen
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